OLFM4


Summary: This gene was originally cloned from human myeloblasts and found to be selectively expressed in inflammed colonic epithelium. This gene encodes a member of the olfactomedin family. The encoded protein is an antiapoptotic factor that promotes tumor growth and is an extracellular matrix glycoprotein that facilitates cell adhesion. [provided by RefSeq, Mar 2011].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM IDMIM:614061
PHARMGKB IDPA134984745
Map Location13q14.3

Gene Categories:

DRUGGABLE GENOME

GO terms in OLFM4


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IEA GO:0003824 catalytic activity
MF IPI GO:0005515 protein binding
MF IMP GO:0042803 protein homodimerization activity
MF IMP GO:0045296 cadherin binding
CC TAS GO:0005576 extracellular region
CC HDA GO:0005615 extracellular space
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Gene expression in normal tissue: OLFM4

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined8Apoptosis regulation1One carbon pool by folate1DNA replication1

Pathways in OLFM4


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Database
Pathway ID
Pathway Des.
reactome R-HSA-168249 Innate Immune System
reactome R-HSA-168256 Immune System
reactome R-HSA-6798695 Neutrophil degranulation
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD427 ABT737 12
iGMDRD171 Pemetrexed 3
iGMDRD433 Lexibulin 3
iGMDRD158 NSC141540 6
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in OLFM4

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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