OLFM4
Summary: This gene was originally cloned from human myeloblasts and found to be selectively expressed in inflammed colonic epithelium. This gene encodes a member of the olfactomedin family. The encoded protein is an antiapoptotic factor that promotes tumor growth and is an extracellular matrix glycoprotein that facilitates cell adhesion. [provided by RefSeq, Mar 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| olfactomedin 4 | MIM:614061 | Ensembl:ENSG00000102837 | HGNC:HGNC:17190 | PA134984745 | 13q14.3 |
Gene Categories:
DRUGGABLE GENOMEGO terms in OLFM4
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0003824 | catalytic activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IMP | GO:0042803 | protein homodimerization activity |
| MF | IMP | GO:0045296 | cadherin binding |
| CC | TAS | GO:0005576 | extracellular region |
| CC | HDA | GO:0005615 | extracellular space |
| CC | IDA | GO:0005615 | extracellular space |
| CC | IMP | GO:0005615 | extracellular space |
| CC | IEA | GO:0005739 | mitochondrion |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | IDA | GO:0030141 | secretory granule |
| CC | TAS | GO:0035580 | specific granule lumen |
| CC | IDA | GO:0042581 | specific granule |
| CC | IDA | GO:0042582 | azurophil granule |
| CC | IDA | GO:0048471 | perinuclear region of cytoplasm |
| CC | HDA | GO:0070062 | extracellular exosome |
| CC | TAS | GO:1904724 | tertiary granule lumen |
| BP | IEA | GO:0007155 | cell adhesion |
| BP | IMP | GO:0010939 | regulation of necrotic cell death |
| BP | IMP | GO:0042981 | regulation of apoptotic process |
| BP | TAS | GO:0043312 | neutrophil degranulation |
| BP | IMP | GO:0050764 | regulation of phagocytosis |
| BP | IMP | GO:0051260 | protein homooligomerization |
| BP | IDA | GO:1900026 | positive regulation of substrate adhesion-dependent cell spreading |
| BP | IMP | GO:2000389 | regulation of neutrophil extravasation |
Gene expression in normal tissue: OLFM4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in OLFM4
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-6798695 | Neutrophil degranulation |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD427 | ABT737 | 12 |
| iGMDRD171 | Pemetrexed | 3 |
| iGMDRD433 | Lexibulin | 3 |
| iGMDRD158 | NSC141540 | 6 |
| iGMDRD126 | Tipifarnib | 1 |
| iGMDRD280 | CYTOCHALASIN B | 6 |
| iGMDRD297 | Austocystin D | 3 |
| iGMDRD85 | Ursolic acid | 1 |
| iGMDRD74 | Idarubicin | 3 |
| iGMDRD446 | LY 2183240 | 1 |
| iGMDRD562 | Navitoclax | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in OLFM4
CLASSFICATION
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