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GRK5

Summary: This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. It has also been shown to play a role in regulating the motility of polymorphonuclear leukocytes (PMNs). [provided by RefSeq, Jul 2008].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
G protein-coupled receptor kinase 5	MIM:600870	Ensembl:ENSG00000198873	HGNC:HGNC:4544	PA180	10q26.11

Gene Categories:

TUMOR SUPPRESSOR SERINE THREONINE KINASE KINASE DRUGGABLE GENOME

GO terms in GRK5

Term Type	Evidence Type	GO Term ID	GO Des.
MF	IDA	GO:0004674	protein serine/threonine kinase activity
MF	IEA	GO:0004703	G-protein coupled receptor kinase activity
MF	TAS	GO:0005080	protein kinase C binding
MF	IPI	GO:0005515	protein binding
MF	IEA	GO:0005524	ATP binding
MF	TAS	GO:0005543	phospholipid binding
MF	IMP	GO:0047696	beta-adrenergic receptor kinase activity
MF	TAS	GO:0047696	beta-adrenergic receptor kinase activity
BP	IEA	GO:0006915	apoptotic process
BP	TAS	GO:0007186	G-protein coupled receptor signaling pathway
BP	TAS	GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
BP	IDA	GO:0007217	tachykinin receptor signaling pathway
BP	TAS	GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
BP	IMP	GO:0008284	positive regulation of cell proliferation
BP	IEA	GO:0016055	Wnt signaling pathway
BP	IDA	GO:0043066	negative regulation of apoptotic process
BP	IEA	GO:0045444	fat cell differentiation
BP	IDA	GO:0046777	protein autophosphorylation
BP	IMP	GO:0051726	regulation of cell cycle
CC	TAS	GO:0005737	cytoplasm
CC	IDA	GO:0005829	cytosol
CC	IDA	GO:0005886	plasma membrane
CC	TAS	GO:0005886	plasma membrane
CC	IDA	GO:0016607	nuclear speck
CC	IDA	GO:0031965	nuclear membrane

Gene expression in normal tissue: GRK5

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in GRK5

Database	Pathway ID	Pathway Des.
reactome	R-HSA-162582	Signal Transduction
reactome	R-HSA-162582	Signal Transduction
reactome	R-HSA-372790	Signaling by GPCR
reactome	R-HSA-372790	Signaling by GPCR
reactome	R-HSA-388396	GPCR downstream signalling
reactome	R-HSA-388396	GPCR downstream signalling
reactome	R-HSA-416476	G alpha (q) signalling events
reactome	R-HSA-418555	G alpha (s) signalling events
pid	alphasynuclein_pathway	Alpha-synuclein signaling
kegg	hsa04062	Chemokine signaling pathway - Homo sapiens (human)
kegg	hsa04144	Endocytosis - Homo sapiens (human)
kegg	hsa05032	Morphine addiction - Homo sapiens (human)
wikipathways	WP289	Myometrial Relaxation and Contraction Pathways
wikipathways	WP3929	Chemokine signaling pathway
wikipathways	WP536	Calcium Regulation in the Cardiac Cell

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD579	PF750	3
iGMDRD494	Neopeltolide	3
iGMDRD405	PIK-75	2
iGMDRD701	NVP-AUY922	2
iGMDRD670	ML 210	2
iGMDRD314	Tanespimycin	2
iGMDRD193	Fqi1	3
iGMDRD446	LY 2183240	4
iGMDRD201	SKI II	2
iGMDRD71	Sparfosic acid	3
iGMDRD634	SCHEMBL2608041	2
iGMDRD211	(1S,3R)-RSL3	2
iGMDRD280	CYTOCHALASIN B	3
iGMDRD123	Isoevodiamine	2
iGMDRD271	Brefeldin A	2
iGMDRD158	NSC141540	3
iGMDRD441	TW 37	2
iGMDRD171	Pemetrexed	3
iGMDRD434	BMS-536924	1
iGMDRD329	Merck60	2
iGMDRD577	BIX01294	1
iGMDRD887	Compound 23 citrate	3
iGMDRD74	Idarubicin	3
iGMDRD451	Serdemetan	2
iGMDRD886	Compound 1541A	2
iGMDRD64	Parbendazole	3
iGMDRD246	NPC26	2
iGMDRD60	Quinoclamine	3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GRK5

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CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.