PTCH2

Summary: This gene encodes a transmembrane receptor of the patched gene family. The encoded protein may function as a tumor suppressor in the hedgehog signaling pathway. Alterations in this gene have been associated with nevoid basal cell carcinoma syndrome, basal cell carcinoma, medulloblastoma, and susceptibility to congenital macrostomia. Alternatively spliced transcript variants have been described.[provided by RefSeq, Oct 2009].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namepatched 2
OMIM IDMIM:603673
Ensembl IDEnsembl:ENSG00000117425
HGNC IDHGNC:HGNC:9586
PHARMGKB IDPA33938
Map Location1p34.1

GO terms in PTCH2


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IBA GO:0005119 smoothened binding
MF IPI GO:0005119 smoothened binding
MF IBA GO:0008158 hedgehog receptor activity
MF TAS GO:0008158 hedgehog receptor activity
MF IBA GO:0097108 hedgehog family protein binding
MF IPI GO:0097108 hedgehog family protein binding
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Gene expression in normal tissue: PTCH2

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 45BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 13BLOOtissue: BLOO cancer: BLOOD model num: 0BLOODtissue: BLOOD cancer: undefined model num: 3UTERUtissue: UTERU cancer: UTERUS model num: 0UTERUStissue: UTERUS cancer: Endometrial Carcinoma (UCEC) model num: 5OVARtissue: OVAR cancer: OVARY model num: 0OVARYtissue: OVARY cancer: undefined model num: 3

Gene-drug pathway distribution

undefined23Other, kinases1ERK MAPK signaling1Apoptosis regulation1DNA replication1

Pathways in PTCH2


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Database
Pathway ID
Pathway Des.
wikipathways WP3313 Hedgehog ,on, state
wikipathways WP4249 Hedgehog Signaling Pathway
wikipathways WP47 Hedgehog Signaling Pathway
netpath Pathway_Hedgehog Hedgehog
pid hedgehog_2pathway Signaling events mediated by the Hedgehog family
kegg hsa04340 Hedgehog signaling pathway - Homo sapiens (human)
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD151 CHM-1 3
iGMDRD433 Lexibulin 2
iGMDRD84 Lovastatin acid 3
iGMDRD126 Tipifarnib 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PTCH2

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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