CLK3
Summary: This gene encodes a protein belonging to the serine/threonine type protein kinase family. This protein is a nuclear dual-specificity kinase that regulates the intranuclear distribution of the serine/arginine-rich (SR) family of splicing factors. Two transcript variants encoding different isoforms have been found for this gene. Related pseudogenes are located on chromosomes 1 and 9. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| CDC like kinase 3 | MIM:602990 | Ensembl:ENSG00000179335 | HGNC:HGNC:2071 | PA26597 | 15q24.1 |
GO terms in CLK3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | IEA | GO:0018108 | peptidyl-tyrosine phosphorylation |
| BP | IDA | GO:0043484 | regulation of RNA splicing |
| BP | IEA | GO:0046777 | protein autophosphorylation |
| CC | IEA | GO:0001669 | acrosomal vesicle |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | HDA | GO:0016020 | membrane |
| CC | IEA | GO:0016607 | nuclear speck |
| CC | IDA | GO:0045111 | intermediate filament cytoskeleton |
| MF | HDA | GO:0003723 | RNA binding |
| MF | ISS | GO:0004674 | protein serine/threonine kinase activity |
| MF | IEA | GO:0004712 | protein serine/threonine/tyrosine kinase activity |
| MF | IEA | GO:0004713 | protein tyrosine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IPI | GO:0042802 | identical protein binding |
Gene expression in normal tissue: CLK3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD289 | Parthenolide | 3 |
| iGMDRD171 | Pemetrexed | 2 |
| iGMDRD801 | 2,4-dideoxy-DC-45-A2 | 2 |
| iGMDRD68 | Paclitaxel | 2 |
| iGMDRD187 | BRD9876 | 2 |
| iGMDRD294 | Batimastat | 2 |
| iGMDRD137 | Indisulam | 2 |
| iGMDRD158 | NSC141540 | 5 |
| iGMDRD886 | Compound 1541A | 3 |
| iGMDRD300 | Tozasertib | 3 |
| iGMDRD60 | Quinoclamine | 3 |
| iGMDRD451 | Serdemetan | 4 |
| iGMDRD524 | ISX-9 | 2 |
| iGMDRD887 | Compound 23 citrate | 2 |
| iGMDRD74 | Idarubicin | 5 |
| iGMDRD329 | Merck60 | 2 |
| iGMDRD427 | ABT737 | 2 |
| iGMDRD483 | SCH-529074 | 3 |
| iGMDRD405 | PIK-75 | 2 |
| iGMDRD512 | nutlin 3 | 1 |
| iGMDRD579 | PF750 | 3 |
| iGMDRD280 | CYTOCHALASIN B | 5 |
| iGMDRD394 | BX-795 | 3 |
| iGMDRD375 | GW-405833 | 2 |
| iGMDRD634 | SCHEMBL2608041 | 5 |
| iGMDRD883 | CIL55A | 2 |
| iGMDRD154 | NSC23766 | 4 |
| iGMDRD85 | Ursolic acid | 1 |
| iGMDRD314 | Tanespimycin | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CLK3
CLASSFICATION
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