CLK3


Summary: This gene encodes a protein belonging to the serine/threonine type protein kinase family. This protein is a nuclear dual-specificity kinase that regulates the intranuclear distribution of the serine/arginine-rich (SR) family of splicing factors. Two transcript variants encoding different isoforms have been found for this gene. Related pseudogenes are located on chromosomes 1 and 9. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM IDMIM:602990
PHARMGKB IDPA26597
Map Location15q24.1

GO terms in CLK3


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IDA GO:0006468 protein phosphorylation
BP IEA GO:0018108 peptidyl-tyrosine phosphorylation
BP IDA GO:0043484 regulation of RNA splicing
BP IEA GO:0046777 protein autophosphorylation
CC IEA GO:0001669 acrosomal vesicle
CC IDA GO:0005634 nucleus
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Gene expression in normal tissue: CLK3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined21Mitosis1p53 pathway1DNA replication1Protein stability and degradation1Leukocyte transendothelial migration1One carbon pool by folate1Metabolic pathways1Chromatin histone acetylation1

Pathways in CLK3


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Database
Pathway ID
Pathway Des.
wikipathways WP411 mRNA Processing
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD289 Parthenolide 3
iGMDRD171 Pemetrexed 2
iGMDRD801 2,4-dideoxy-DC-45-A2 2
iGMDRD68 Paclitaxel 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CLK3

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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