FOXO3

Summary: This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Nameforkhead box O3
OMIM IDMIM:602681
Ensembl IDEnsembl:ENSG00000118689
HGNC IDHGNC:HGNC:3821
PHARMGKB IDPA28239
Map Location6q21

GO terms in FOXO3


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Term Type
Evidence Type
GO Term ID
GO Des.
MF ISS GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding
MF IBA GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF ISA GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF ISM GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF IEA GO:0001221 transcription cofactor binding
MF IDA GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
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Gene expression in normal tissue: FOXO3

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 60OVARtissue: OVAR cancer: OVARY model num: 0OVARYtissue: OVARY cancer: undefined model num: 16UTERUtissue: UTERU cancer: UTERUS model num: 0UTERUStissue: UTERUS cancer: Endometrial Carcinoma (UCEC) model num: 6BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 7

Gene-drug pathway distribution

undefined36Biosynthesis of secondary metabolites2IGFR signaling1Cytoskeleton1Bile secretion1Th17 cell differentiation1Longevity regulating pathway1Other, kinases1ERK MAPK signaling1DNA replication1

Pathways in FOXO3


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Database
Pathway ID
Pathway Des.
biocarta achpathway role of nicotinic acetylcholine receptors in the regulation of apoptosis
biocarta aktpathway akt signaling pathway
biocarta longevitypathway the igf-1 receptor and longevity
biocarta ptenpathway pten dependent cell cycle arrest and apoptosis
reactome R-HSA-1181150 Signaling by NODAL
reactome R-HSA-1257604 PIP3 activates AKT signaling
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD560 MK-2206 3
iGMDRD382 CEP-701 1
iGMDRD307 Manumycin A 1
iGMDRD486 Tosedostat 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FOXO3

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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