FOXO3
Summary: This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| forkhead box O3 | MIM:602681 | Ensembl:ENSG00000118689 | HGNC:HGNC:3821 | PA28239 | 6q21 |
GO terms in FOXO3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ISS | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IBA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IEA | GO:0001221 | transcription cofactor binding |
| MF | IDA | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding |
| MF | IEA | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding |
| MF | IDA | GO:0003677 | DNA binding |
| MF | IBA | GO:0003700 | DNA-binding transcription factor activity |
| MF | IDA | GO:0003700 | DNA-binding transcription factor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0008013 | beta-catenin binding |
| MF | IBA | GO:0008134 | transcription factor binding |
| MF | IPI | GO:0019901 | protein kinase binding |
| MF | ISS | GO:0031490 | chromatin DNA binding |
| MF | IMP | GO:0034246 | mitochondrial sequence-specific DNA-binding transcription factor activity |
| MF | IBA | GO:0043565 | sequence-specific DNA binding |
| MF | IDA | GO:0043565 | sequence-specific DNA binding |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IMP | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005739 | mitochondrion |
| CC | IDA | GO:0005741 | mitochondrial outer membrane |
| CC | IDA | GO:0005759 | mitochondrial matrix |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0032991 | protein-containing complex |
| BP | IBA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IDA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IMP | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0001542 | ovulation from ovarian follicle |
| BP | IEA | GO:0001544 | initiation of primordial ovarian follicle growth |
| BP | IEA | GO:0001547 | antral ovarian follicle growth |
| BP | IEA | GO:0001556 | oocyte maturation |
| BP | ISS | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0006366 | transcription by RNA polymerase II |
| BP | IMP | GO:0006390 | mitochondrial transcription |
| BP | IDA | GO:0006417 | regulation of translation |
| BP | IEA | GO:0007568 | aging |
| BP | IBA | GO:0008286 | insulin receptor signaling pathway |
| BP | TAS | GO:0019221 | cytokine-mediated signaling pathway |
| BP | IEA | GO:0030330 | DNA damage response, signal transduction by p53 class mediator |
| BP | IEA | GO:0031667 | response to nutrient levels |
| BP | IMP | GO:0033209 | tumor necrosis factor-mediated signaling pathway |
| BP | ISS | GO:0034599 | cellular response to oxidative stress |
| BP | IBA | GO:0042593 | glucose homeostasis |
| BP | IDA | GO:0043065 | positive regulation of apoptotic process |
| BP | IMP | GO:0043525 | positive regulation of neuron apoptotic process |
| BP | IDA | GO:0045648 | positive regulation of erythrocyte differentiation |
| BP | IEA | GO:0045665 | negative regulation of neuron differentiation |
| BP | IDA | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IBA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0048854 | brain morphogenesis |
| BP | IEA | GO:0071333 | cellular response to glucose stimulus |
| BP | IEA | GO:0071386 | cellular response to corticosterone stimulus |
| BP | IEA | GO:0071456 | cellular response to hypoxia |
| BP | IEA | GO:0071548 | response to dexamethasone |
| BP | IEA | GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| BP | IEA | GO:0097150 | neuronal stem cell population maintenance |
| BP | IEA | GO:0097192 | extrinsic apoptotic signaling pathway in absence of ligand |
| BP | IEA | GO:1901300 | positive regulation of hydrogen peroxide-mediated programmed cell death |
| BP | IEA | GO:1903428 | positive regulation of reactive oxygen species biosynthetic process |
| BP | IEA | GO:1904646 | cellular response to amyloid-beta |
| BP | IEA | GO:1990090 | cellular response to nerve growth factor stimulus |
| BP | IEA | GO:1990785 | response to water-immersion restraint stress |
| BP | IEA | GO:2000177 | regulation of neural precursor cell proliferation |
| BP | IEA | GO:2000353 | positive regulation of endothelial cell apoptotic process |
Gene expression in normal tissue: FOXO3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in FOXO3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | achpathway | role of nicotinic acetylcholine receptors in the regulation of apoptosis |
| biocarta | aktpathway | akt signaling pathway |
| biocarta | longevitypathway | the igf-1 receptor and longevity |
| biocarta | ptenpathway | pten dependent cell cycle arrest and apoptosis |
| reactome | R-HSA-1181150 | Signaling by NODAL |
| reactome | R-HSA-1257604 | PIP3 activates AKT signaling |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-198693 | AKT phosphorylates targets in the nucleus |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-2219528 | PI3K/AKT Signaling in Cancer |
| reactome | R-HSA-447115 | Interleukin-12 family signaling |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| reactome | R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer |
| reactome | R-HSA-5683057 | MAPK family signaling cascades |
| reactome | R-HSA-5687128 | MAPK6/MAPK4 signaling |
| reactome | R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models |
| reactome | R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models |
| reactome | R-HSA-8863678 | Neurodegenerative Diseases |
| reactome | R-HSA-8863678 | Neurodegenerative Diseases |
| reactome | R-HSA-8878159 | Transcriptional regulation by RUNX3 |
| reactome | R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation |
| reactome | R-HSA-8952158 | RUNX3 regulates BCL2L11 (BIM) transcription |
| reactome | R-HSA-9006925 | Intracellular signaling by second messengers |
| reactome | R-HSA-9020591 | Interleukin-12 signaling |
| wikipathways | WP127 | IL-5 Signaling Pathway |
| wikipathways | WP1541 | Energy Metabolism |
| wikipathways | WP2261 | Signaling Pathways in Glioblastoma |
| wikipathways | WP2380 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| wikipathways | WP2431 | Spinal Cord Injury |
| wikipathways | WP304 | Kit receptor signaling pathway |
| wikipathways | WP3286 | Copper homeostasis |
| wikipathways | WP3630 | NAD metabolism, sirtuins and aging |
| wikipathways | WP3640 | Imatinib and Chronic Myeloid Leukemia |
| wikipathways | WP3651 | Pathways Affected in Adenoid Cystic Carcinoma |
| wikipathways | WP3844 | PI3K-AKT-mTOR signaling pathway and therapeutic opportunities |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| wikipathways | WP3915 | Angiopoietin Like Protein 8 Regulatory Pathway |
| wikipathways | WP3929 | Chemokine signaling pathway |
| wikipathways | WP3932 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| wikipathways | WP3987 | HDAC6 interactions |
| wikipathways | WP4066 | Interleukin-4 and 13 signaling |
| wikipathways | WP4155 | Endometrial cancer |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| wikipathways | WP481 | Insulin Signaling |
| wikipathways | WP49 | IL-2 Signaling Pathway |
| wikipathways | WP710 | DNA Damage Response (only ATM dependent) |
| pid | foxopathway | FoxO family signaling |
| pid | hdac_classiii_pathway | Signaling events mediated by HDAC Class III |
| pid | il2_pi3kpathway | IL2 signaling events mediated by PI3K |
| pid | insulin_pathway | Insulin Pathway |
| pid | kitpathway | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| pid | myc_represspathway | Validated targets of C-MYC transcriptional repression |
| pid | p73pathway | p73 transcription factor network |
| pid | pi3kciaktpathway | Class I PI3K signaling events mediated by Akt |
| pid | pi3kcipathway | Class I PI3K signaling events |
| pid | pi3kplctrkpathway | Trk receptor signaling mediated by PI3K and PLC-gamma |
| pid | smad2_3nuclearpathway | Regulation of nuclear SMAD2/3 signaling |
| kegg | hsa04062 | Chemokine signaling pathway - Homo sapiens (human) |
| kegg | hsa04068 | FoxO signaling pathway - Homo sapiens (human) |
| kegg | hsa04137 | Mitophagy - animal - Homo sapiens (human) |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa04152 | AMPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04211 | Longevity regulating pathway - Homo sapiens (human) |
| kegg | hsa04213 | Longevity regulating pathway - multiple species - Homo sapiens (human) |
| kegg | hsa04218 | Cellular senescence - Homo sapiens (human) |
| kegg | hsa04722 | Neurotrophin signaling pathway - Homo sapiens (human) |
| kegg | hsa04917 | Prolactin signaling pathway - Homo sapiens (human) |
| kegg | hsa05213 | Endometrial cancer - Homo sapiens (human) |
| kegg | hsa05223 | Non-small cell lung cancer - Homo sapiens (human) |
| netpath | Pathway_BCR | BCR |
| netpath | Pathway_BDNF | BDNF |
| netpath | Pathway_IL-7 | IL-7 |
| netpath | Pathway_IL2 | IL2 |
| netpath | Pathway_IL5 | IL5 |
| netpath | Pathway_IL6 | IL6 |
| netpath | Pathway_RAGE | RAGE |
| netpath | Pathway_TGF_beta_Receptor | TGF_beta_Receptor |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD560 | MK-2206 | 3 |
| iGMDRD382 | CEP-701 | 1 |
| iGMDRD307 | Manumycin A | 1 |
| iGMDRD486 | Tosedostat | 1 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 4 |
| iGMDRD154 | NSC23766 | 3 |
| iGMDRD123 | Isoevodiamine | 2 |
| iGMDRD536 | PLX-4720 | 1 |
| iGMDRD16 | CICLOPIROX | 1 |
| iGMDRD213 | SMR000068650 | 2 |
| iGMDRD158 | NSC141540 | 2 |
| iGMDRD82 | Quiflapon | 2 |
| iGMDRD505 | Pevonedistat | 1 |
| iGMDRD329 | Merck60 | 1 |
| iGMDRD414 | MST-312 | 2 |
| iGMDRD286 | Nsc 632839 | 1 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD63 | Camptothecin | 1 |
| iGMDRD427 | ABT737 | 3 |
| iGMDRD428 | Brivanib | 1 |
| iGMDRD772 | BRD4770 | 2 |
| iGMDRD857 | BRD-K70511574 | 1 |
| iGMDRD420 | Leucascandrolide A | 3 |
| iGMDRD579 | PF750 | 2 |
| iGMDRD112 | Methotrexate | 1 |
| iGMDRD151 | CHM-1 | 2 |
| iGMDRD297 | Austocystin D | 1 |
| iGMDRD626 | BRD-K33199242 | 1 |
| iGMDRD280 | CYTOCHALASIN B | 5 |
| iGMDRD394 | BX-795 | 3 |
| iGMDRD316 | N9-Isopropyl-olomoucine | 2 |
| iGMDRD193 | Fqi1 | 2 |
| iGMDRD446 | LY 2183240 | 2 |
| iGMDRD201 | SKI II | 2 |
| iGMDRD870 | BRD63610 | 1 |
| iGMDRD52 | Rotenone | 2 |
| iGMDRD573 | GSK-1904529A | 1 |
| iGMDRD255 | SB225002 | 6 |
| iGMDRD493 | GSK269962A | 1 |
| iGMDRD862 | BRD-K94991378 | 1 |
| iGMDRD270 | Ciclosporin | 2 |
| iGMDRD23 | Gossypol | 1 |
| iGMDRD64 | Parbendazole | 1 |
| iGMDRD888 | Compound 44 | 1 |
| iGMDRD100 | Zebularine | 3 |
| iGMDRD887 | Compound 23 citrate | 1 |
| iGMDRD641 | SCH 79797 | 1 |
| iGMDRD74 | Idarubicin | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in FOXO3
CLASSFICATION
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