PIK3C3
Summary:
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| phosphatidylinositol 3-kinase catalytic subunit type 3 | MIM:602609 | Ensembl:ENSG00000078142 | HGNC:HGNC:8974 | PA33307 | 18q12.3 |
GO terms in PIK3C3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0000407 | phagophore assembly site |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IBA | GO:0005768 | endosome |
| CC | IDA | GO:0005770 | late endosome |
| CC | IBA | GO:0005777 | peroxisome |
| CC | TAS | GO:0005829 | cytosol |
| CC | ISS | GO:0005930 | axoneme |
| CC | HDA | GO:0016020 | membrane |
| CC | IBA | GO:0016020 | membrane |
| CC | IDA | GO:0030496 | midbody |
| CC | TAS | GO:0030670 | phagocytic vesicle membrane |
| CC | IBA | GO:0034271 | phosphatidylinositol 3-kinase complex, class III, type I |
| CC | IBA | GO:0034272 | phosphatidylinositol 3-kinase complex, class III, type II |
| CC | ISS | GO:0035032 | phosphatidylinositol 3-kinase complex, class III |
| CC | IDA | GO:0044754 | autolysosome |
| BP | IBA | GO:0000045 | autophagosome assembly |
| BP | IBA | GO:0006468 | protein phosphorylation |
| BP | IMP | GO:0006497 | protein lipidation |
| BP | IBA | GO:0006897 | endocytosis |
| BP | IMP | GO:0006914 | autophagy |
| BP | IEA | GO:0007032 | endosome organization |
| BP | IEA | GO:0007049 | cell cycle |
| BP | ISS | GO:0016236 | macroautophagy |
| BP | TAS | GO:0016236 | macroautophagy |
| BP | IEA | GO:0016485 | protein processing |
| BP | IBA | GO:0030242 | autophagy of peroxisome |
| BP | IMP | GO:0032465 | regulation of cytokinesis |
| BP | TAS | GO:0034162 | toll-like receptor 9 signaling pathway |
| BP | IEA | GO:0034497 | protein localization to phagophore assembly site |
| BP | IBA | GO:0036092 | phosphatidylinositol-3-phosphate biosynthetic process |
| BP | IEA | GO:0036092 | phosphatidylinositol-3-phosphate biosynthetic process |
| BP | ISS | GO:0042149 | cellular response to glucose starvation |
| BP | IEA | GO:0043201 | response to leucine |
| BP | IMP | GO:0045022 | early endosome to late endosome transport |
| BP | IBA | GO:0046854 | phosphatidylinositol phosphorylation |
| BP | IEA | GO:0046854 | phosphatidylinositol phosphorylation |
| BP | IBA | GO:0048015 | phosphatidylinositol-mediated signaling |
| BP | IEA | GO:0050708 | regulation of protein secretion |
| BP | IEA | GO:0051301 | cell division |
| MF | IEA | GO:0004672 | protein kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IDA | GO:0016301 | kinase activity |
| MF | IBA | GO:0016303 | 1-phosphatidylinositol-3-kinase activity |
| MF | IMP | GO:0016303 | 1-phosphatidylinositol-3-kinase activity |
| MF | TAS | GO:0016303 | 1-phosphatidylinositol-3-kinase activity |
| MF | IBA | GO:0052742 | phosphatidylinositol kinase activity |
Gene expression in normal tissue: PIK3C3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PIK3C3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa00562 | Inositol phosphate metabolism - Homo sapiens (human) |
| kegg | hsa04070 | Phosphatidylinositol signaling system - Homo sapiens (human) |
| kegg | hsa04136 | Autophagy - other - Homo sapiens (human) |
| kegg | hsa04140 | Autophagy - animal - Homo sapiens (human) |
| kegg | hsa04145 | Phagosome - Homo sapiens (human) |
| kegg | hsa04371 | Apelin signaling pathway - Homo sapiens (human) |
| kegg | hsa05152 | Tuberculosis - Homo sapiens (human) |
| kegg | hsa05167 | Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human) |
| humancyc | PWY-6352 | 3-phosphoinositide biosynthesis |
| humancyc | PWY-6371 | superpathway of inositol phosphate compounds |
| smpdb | SMP00011 | Inositol Metabolism |
| smpdb | SMP00463 | Phosphatidylinositol Phosphate Metabolism |
| smpdb | SMP00582 | Joubert syndrome |
| wikipathways | WP1403 | AMP-activated Protein Kinase (AMPK) Signaling |
| wikipathways | WP3915 | Angiopoietin Like Protein 8 Regulatory Pathway |
| wikipathways | WP3937 | Microglia Pathogen Phagocytosis Pathway |
| wikipathways | WP481 | Insulin Signaling |
| wikipathways | WP51 | Regulation of Actin Cytoskeleton |
| wikipathways | WP615 | Senescence and Autophagy in Cancer |
| wikipathways | WP710 | DNA Damage Response (only ATM dependent) |
| reactome | R-HSA-109704 | PI3K Cascade |
| reactome | R-HSA-112399 | IRS-mediated signalling |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1483255 | PI Metabolism |
| reactome | R-HSA-1483257 | Phospholipid metabolism |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1632852 | Macroautophagy |
| reactome | R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane |
| reactome | R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane |
| reactome | R-HSA-1660517 | Synthesis of PIPs at the late endosome membrane |
| reactome | R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168898 | Toll-Like Receptors Cascades |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-195258 | RHO GTPase Effectors |
| reactome | R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) |
| reactome | R-HSA-2428924 | IGF1R signaling cascade |
| reactome | R-HSA-2428928 | IRS-related events triggered by IGF1R |
| reactome | R-HSA-556833 | Metabolism of lipids |
| reactome | R-HSA-5668599 | RHO GTPases Activate NADPH Oxidases |
| reactome | R-HSA-74751 | Insulin receptor signalling cascade |
| reactome | R-HSA-74752 | Signaling by Insulin receptor |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD150 | RITA | 3 |
| iGMDRD523 | Cyanoquinoline, 11 | 2 |
| iGMDRD248 | BRD4354 | 1 |
| iGMDRD148 | Pifithrin-mu | 2 |
| iGMDRD123 | Isoevodiamine | 1 |
| iGMDRD154 | NSC23766 | 4 |
| iGMDRD314 | Tanespimycin | 2 |
| iGMDRD6 | AM-580 | 4 |
| iGMDRD481 | Dactolisib | 1 |
| iGMDRD77 | Itraconazole | 2 |
| iGMDRD137 | Indisulam | 2 |
| iGMDRD158 | NSC141540 | 4 |
| iGMDRD367 | Ro 28-1675 | 3 |
| iGMDRD286 | Nsc 632839 | 5 |
| iGMDRD872 | BRD7137 | 2 |
| iGMDRD329 | Merck60 | 4 |
| iGMDRD779 | PRL-3 Inhibitor I | 4 |
| iGMDRD427 | ABT737 | 4 |
| iGMDRD670 | ML 210 | 2 |
| iGMDRD494 | Neopeltolide | 2 |
| iGMDRD554 | CHEMBL1434137 | 4 |
| iGMDRD1008 | SR-II-138A | 1 |
| iGMDRD466 | Chaetocin | 2 |
| iGMDRD280 | CYTOCHALASIN B | 6 |
| iGMDRD375 | GW-405833 | 2 |
| iGMDRD226 | ML006 | 5 |
| iGMDRD441 | TW 37 | 4 |
| iGMDRD294 | Batimastat | 1 |
| iGMDRD187 | BRD9876 | 1 |
| iGMDRD52 | Rotenone | 2 |
| iGMDRD870 | BRD63610 | 4 |
| iGMDRD802 | 4-methylfasudil | 2 |
| iGMDRD451 | Serdemetan | 2 |
| iGMDRD74 | Idarubicin | 3 |
| iGMDRD888 | Compound 44 | 5 |
| iGMDRD506 | Fedratinib | 1 |
| iGMDRD562 | Navitoclax | 2 |
| iGMDRD398 | Sepantronium | 1 |
| iGMDRD780 | PP-30 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PIK3C3
CLASSFICATION
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