RELA
Summary: NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| RELA proto-oncogene, NF-kB subunit | MIM:164014 | Ensembl:ENSG00000173039 | HGNC:HGNC:9955 | PA296 | 11q13.1 |
GO terms in RELA
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0000790 | nuclear chromatin |
| CC | IDA | GO:0005634 | nucleus |
| CC | IMP | GO:0005634 | nucleus |
| CC | IBA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005667 | transcription factor complex |
| CC | IDA | GO:0005730 | nucleolus |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IBA | GO:0005829 | cytosol |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IBA | GO:0033256 | I-kappaB/NF-kappaB complex |
| CC | IDA | GO:0035525 | NF-kappaB p50/p65 complex |
| BP | IBA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IDA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0001889 | liver development |
| BP | IEA | GO:0001942 | hair follicle development |
| BP | TAS | GO:0002223 | stimulatory C-type lectin receptor signaling pathway |
| BP | IEA | GO:0006117 | acetaldehyde metabolic process |
| BP | IMP | GO:0006355 | regulation of transcription, DNA-templated |
| BP | IBA | GO:0006954 | inflammatory response |
| BP | IDA | GO:0006954 | inflammatory response |
| BP | NAS | GO:0006968 | cellular defense response |
| BP | IBA | GO:0007249 | I-kappaB kinase/NF-kappaB signaling |
| BP | IEA | GO:0007568 | aging |
| BP | IDA | GO:0008284 | positive regulation of cell proliferation |
| BP | IEA | GO:0009887 | animal organ morphogenesis |
| BP | IDA | GO:0010033 | response to organic substance |
| BP | IDA | GO:0010224 | response to UV-B |
| BP | IEA | GO:0014040 | positive regulation of Schwann cell differentiation |
| BP | IEA | GO:0016032 | viral process |
| BP | IDA | GO:0019221 | cytokine-mediated signaling pathway |
| BP | TAS | GO:0031293 | membrane protein intracellular domain proteolysis |
| BP | IEA | GO:0032332 | positive regulation of chondrocyte differentiation |
| BP | TAS | GO:0032481 | positive regulation of type I interferon production |
| BP | IEA | GO:0032495 | response to muramyl dipeptide |
| BP | IEA | GO:0032570 | response to progesterone |
| BP | IEA | GO:0032868 | response to insulin |
| BP | IDA | GO:0033209 | tumor necrosis factor-mediated signaling pathway |
| BP | IEA | GO:0033234 | negative regulation of protein sumoylation |
| BP | IEA | GO:0033590 | response to cobalamin |
| BP | IBA | GO:0034097 | response to cytokine |
| BP | IEA | GO:0035729 | cellular response to hepatocyte growth factor stimulus |
| BP | IMP | GO:0035924 | cellular response to vascular endothelial growth factor stimulus |
| BP | IEA | GO:0035994 | response to muscle stretch |
| BP | IBA | GO:0038061 | NIK/NF-kappaB signaling |
| BP | TAS | GO:0038095 | Fc-epsilon receptor signaling pathway |
| BP | IEA | GO:0042177 | negative regulation of protein catabolic process |
| BP | IDA | GO:0043066 | negative regulation of apoptotic process |
| BP | TAS | GO:0043066 | negative regulation of apoptotic process |
| BP | IEP | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling |
| BP | IEA | GO:0043200 | response to amino acid |
| BP | IEA | GO:0043278 | response to morphine |
| BP | IMP | GO:0043620 | regulation of DNA-templated transcription in response to stress |
| BP | IEA | GO:0045084 | positive regulation of interleukin-12 biosynthetic process |
| BP | IBA | GO:0045087 | innate immune response |
| BP | IDA | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | IDA | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IMP | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IBA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IMP | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0046627 | negative regulation of insulin receptor signaling pathway |
| BP | ISS | GO:0050727 | regulation of inflammatory response |
| BP | TAS | GO:0050852 | T cell receptor signaling pathway |
| BP | IMP | GO:0050862 | positive regulation of T cell receptor signaling pathway |
| BP | IDA | GO:0051092 | positive regulation of NF-kappaB transcription factor activity |
| BP | IGI | GO:0051092 | positive regulation of NF-kappaB transcription factor activity |
| BP | IMP | GO:0051092 | positive regulation of NF-kappaB transcription factor activity |
| BP | TAS | GO:0051092 | positive regulation of NF-kappaB transcription factor activity |
| BP | IEA | GO:0051591 | response to cAMP |
| BP | NAS | GO:0051607 | defense response to virus |
| BP | IMP | GO:0061614 | pri-miRNA transcription by RNA polymerase II |
| BP | IDA | GO:0070301 | cellular response to hydrogen peroxide |
| BP | IDA | GO:0070431 | nucleotide-binding oligomerization domain containing 2 signaling pathway |
| BP | TAS | GO:0070498 | interleukin-1-mediated signaling pathway |
| BP | IGI | GO:0070555 | response to interleukin-1 |
| BP | IEA | GO:0071222 | cellular response to lipopolysaccharide |
| BP | IMP | GO:0071223 | cellular response to lipoteichoic acid |
| BP | IMP | GO:0071224 | cellular response to peptidoglycan |
| BP | IMP | GO:0071316 | cellular response to nicotine |
| BP | IDA | GO:0071347 | cellular response to interleukin-1 |
| BP | IMP | GO:0071354 | cellular response to interleukin-6 |
| BP | IDA | GO:0071356 | cellular response to tumor necrosis factor |
| BP | IMP | GO:0071356 | cellular response to tumor necrosis factor |
| BP | IGI | GO:1901222 | regulation of NIK/NF-kappaB signaling |
| BP | IMP | GO:1901223 | negative regulation of NIK/NF-kappaB signaling |
| BP | IDA | GO:1901224 | positive regulation of NIK/NF-kappaB signaling |
| BP | IMP | GO:1901224 | positive regulation of NIK/NF-kappaB signaling |
| BP | IMP | GO:1901522 | positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus |
| BP | IMP | GO:1902894 | negative regulation of pri-miRNA transcription by RNA polymerase II |
| BP | IMP | GO:1902895 | positive regulation of pri-miRNA transcription by RNA polymerase II |
| BP | IMP | GO:1904385 | cellular response to angiotensin |
| BP | IMP | GO:2000630 | positive regulation of miRNA metabolic process |
| BP | IMP | GO:2001237 | negative regulation of extrinsic apoptotic signaling pathway |
| MF | IBA | GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding |
| MF | IDA | GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding |
| MF | IMP | GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding |
| MF | IDA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IDA | GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding |
| MF | IBA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IMP | GO:0000983 | transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding |
| MF | IDA | GO:0001077 | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IDA | GO:0001078 | transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IDA | GO:0001205 | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding |
| MF | IDA | GO:0003677 | DNA binding |
| MF | IMP | GO:0003677 | DNA binding |
| MF | IBA | GO:0003682 | chromatin binding |
| MF | IDA | GO:0003682 | chromatin binding |
| MF | IDA | GO:0003700 | DNA-binding transcription factor activity |
| MF | IMP | GO:0003700 | DNA-binding transcription factor activity |
| MF | IDA | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0008134 | transcription factor binding |
| MF | IPI | GO:0019901 | protein kinase binding |
| MF | IDA | GO:0031490 | chromatin DNA binding |
| MF | IPI | GO:0031625 | ubiquitin protein ligase binding |
| MF | IPI | GO:0033613 | activating transcription factor binding |
| MF | IDA | GO:0042301 | phosphate ion binding |
| MF | IDA | GO:0042802 | identical protein binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IDA | GO:0042803 | protein homodimerization activity |
| MF | IPI | GO:0042805 | actinin binding |
| MF | IPI | GO:0042826 | histone deacetylase binding |
| MF | IDA | GO:0044212 | transcription regulatory region DNA binding |
| MF | IEA | GO:0044877 | protein-containing complex binding |
| MF | IDA | GO:0046982 | protein heterodimerization activity |
| MF | IPI | GO:0047485 | protein N-terminus binding |
| MF | IPI | GO:0051059 | NF-kappaB binding |
| MF | IPI | GO:0070491 | repressing transcription factor binding |
| MF | IEA | GO:0071532 | ankyrin repeat binding |
Gene expression in normal tissue: RELA
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RELA
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP138 | Androgen receptor signaling pathway |
| wikipathways | WP1433 | Nucleotide-binding Oligomerization Domain (NOD) pathway |
| wikipathways | WP1434 | Osteopontin Signaling |
| wikipathways | WP1449 | Regulation of toll-like receptor signaling pathway |
| wikipathways | WP15 | Selenium Micronutrient Network |
| wikipathways | WP1533 | Vitamin B12 Metabolism |
| wikipathways | WP176 | Folate Metabolism |
| wikipathways | WP195 | IL-1 signaling pathway |
| wikipathways | WP2018 | RANKL-RANK (Receptor activator of NFKB (ligand)) Signaling Pathway |
| wikipathways | WP2034 | Leptin signaling pathway |
| wikipathways | WP2036 | TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway |
| wikipathways | WP2037 | Prolactin Signaling Pathway |
| wikipathways | WP2112 | IL17 signaling pathway |
| wikipathways | WP2203 | Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway |
| wikipathways | WP23 | B Cell Receptor Signaling Pathway |
| wikipathways | WP2324 | AGE-RAGE pathway |
| wikipathways | WP2332 | Interleukin-11 Signaling Pathway |
| wikipathways | WP2355 | Corticotropin-releasing hormone signaling pathway |
| wikipathways | WP2374 | Oncostatin M Signaling Pathway |
| wikipathways | WP2380 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| wikipathways | WP254 | Apoptosis |
| wikipathways | WP2586 | Aryl Hydrocarbon Receptor |
| wikipathways | WP262 | EBV LMP1 signaling |
| wikipathways | WP2637 | Structural Pathway of Interleukin 1 (IL-1) |
| wikipathways | WP28 | Selenium Metabolism and Selenoproteins |
| wikipathways | WP288 | NLR Proteins |
| wikipathways | WP3303 | Rac1-Pak1-p38-MMP-2 pathway |
| wikipathways | WP3414 | Initiation of transcription and translation elongation at the HIV-1 LTR |
| wikipathways | WP3617 | Photodynamic therapy-induced NF-kB survival signaling |
| wikipathways | WP3639 | Apoptotic Signaling Pathway |
| wikipathways | WP382 | MAPK Signaling Pathway |
| wikipathways | WP3858 | Toll-like Receptor Signaling |
| wikipathways | WP3865 | RIG-I-like Receptor Signaling |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| wikipathways | WP3926 | ApoE and miR-146 in inflammation and atherosclerosis |
| wikipathways | WP3929 | Chemokine signaling pathway |
| wikipathways | WP395 | IL-4 Signaling Pathway |
| wikipathways | WP4008 | NO-cGMP-PKG mediated Neuroprotection |
| wikipathways | WP4141 | PI3K-AKT-mTOR - VitD3 Signalling |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| wikipathways | WP4223 | Ras Signaling |
| wikipathways | WP69 | T-Cell antigen Receptor (TCR) Signaling Pathway |
| wikipathways | WP75 | Toll-like Receptor Signaling Pathway |
| netpath | Pathway_BCR | BCR |
| netpath | Pathway_BDNF | BDNF |
| netpath | Pathway_CRH | CRH |
| netpath | Pathway_EGFR1 | EGFR1 |
| netpath | Pathway_Gastrin | Gastrin |
| netpath | Pathway_Ghrelin | Ghrelin |
| netpath | Pathway_IL1 | IL1 |
| netpath | Pathway_IL11 | IL11 |
| netpath | Pathway_IL2 | IL2 |
| netpath | Pathway_KitReceptor | KitReceptor |
| netpath | Pathway_Notch | Notch |
| netpath | Pathway_Oncostatin_M | Oncostatin_M |
| netpath | Pathway_Prolactin | Prolactin |
| netpath | Pathway_RAGE | RAGE |
| netpath | Pathway_TCR | TCR |
| netpath | Pathway_TNFalpha | TNFalpha |
| netpath | Pathway_TSLP | TSLP |
| netpath | Pathway_TWEAK | TWEAK |
| pid | angiopoietinreceptor_pathway | Angiopoietin receptor Tie2-mediated signaling |
| pid | avb3_opn_pathway | Osteopontin-mediated events |
| pid | bcr_5pathway | BCR signaling pathway |
| pid | cd40_pathway | CD40/CD40L signaling |
| pid | ceramide_pathway | Ceramide signaling pathway |
| pid | fcer1pathway | Fc-epsilon receptor I signaling in mast cells |
| pid | hdac_classi_pathway | Signaling events mediated by HDAC Class I |
| pid | hivnefpathway | HIV-1 Nef: Negative effector of Fas and TNF-alpha |
| pid | il12_2pathway | IL12-mediated signaling events |
| pid | il1pathway | IL1-mediated signaling events |
| pid | il23pathway | IL23-mediated signaling events |
| pid | il2_pi3kpathway | IL2 signaling events mediated by PI3K |
| pid | lysophospholipid_pathway | LPA receptor mediated events |
| pid | nfkappabatypicalpathway | Atypical NF-kappaB pathway |
| pid | nfkappabcanonicalpathway | Canonical NF-kappaB pathway |
| pid | p73pathway | p73 transcription factor network |
| pid | reg_gr_pathway | Glucocorticoid receptor regulatory network |
| pid | tnfpathway | TNF receptor signaling pathway |
| pharmgkb | PA162356267 | EGFR Inhibitor Pathway, Pharmacodynamics |
| pharmgkb | PA165985892 | Tacrolimus/Cyclosporine Pathway, Pharmacodynamics |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04014 | Ras signaling pathway - Homo sapiens (human) |
| kegg | hsa04024 | cAMP signaling pathway - Homo sapiens (human) |
| kegg | hsa04062 | Chemokine signaling pathway - Homo sapiens (human) |
| kegg | hsa04064 | NF-kappa B signaling pathway - Homo sapiens (human) |
| kegg | hsa04066 | HIF-1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04071 | Sphingolipid signaling pathway - Homo sapiens (human) |
| kegg | hsa04137 | Mitophagy - animal - Homo sapiens (human) |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa04210 | Apoptosis - Homo sapiens (human) |
| kegg | hsa04211 | Longevity regulating pathway - Homo sapiens (human) |
| kegg | hsa04218 | Cellular senescence - Homo sapiens (human) |
| kegg | hsa04380 | Osteoclast differentiation - Homo sapiens (human) |
| kegg | hsa04620 | Toll-like receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04621 | NOD-like receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04622 | RIG-I-like receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04623 | Cytosolic DNA-sensing pathway - Homo sapiens (human) |
| kegg | hsa04625 | C-type lectin receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04657 | IL-17 signaling pathway - Homo sapiens (human) |
| kegg | hsa04658 | Th1 and Th2 cell differentiation - Homo sapiens (human) |
| kegg | hsa04659 | Th17 cell differentiation - Homo sapiens (human) |
| kegg | hsa04660 | T cell receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04662 | B cell receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04668 | TNF signaling pathway - Homo sapiens (human) |
| kegg | hsa04722 | Neurotrophin signaling pathway - Homo sapiens (human) |
| kegg | hsa04917 | Prolactin signaling pathway - Homo sapiens (human) |
| kegg | hsa04920 | Adipocytokine signaling pathway - Homo sapiens (human) |
| kegg | hsa04926 | Relaxin signaling pathway - Homo sapiens (human) |
| kegg | hsa04931 | Insulin resistance - Homo sapiens (human) |
| kegg | hsa04932 | Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human) |
| kegg | hsa04933 | AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human) |
| kegg | hsa05030 | Cocaine addiction - Homo sapiens (human) |
| kegg | hsa05120 | Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human) |
| kegg | hsa05131 | Shigellosis - Homo sapiens (human) |
| kegg | hsa05132 | Salmonella infection - Homo sapiens (human) |
| kegg | hsa05133 | Pertussis - Homo sapiens (human) |
| kegg | hsa05134 | Legionellosis - Homo sapiens (human) |
| kegg | hsa05140 | Leishmaniasis - Homo sapiens (human) |
| kegg | hsa05142 | Chagas disease (American trypanosomiasis) - Homo sapiens (human) |
| kegg | hsa05145 | Toxoplasmosis - Homo sapiens (human) |
| kegg | hsa05146 | Amoebiasis - Homo sapiens (human) |
| kegg | hsa05152 | Tuberculosis - Homo sapiens (human) |
| kegg | hsa05160 | Hepatitis C - Homo sapiens (human) |
| kegg | hsa05161 | Hepatitis B - Homo sapiens (human) |
| kegg | hsa05162 | Measles - Homo sapiens (human) |
| kegg | hsa05164 | Influenza A - Homo sapiens (human) |
| kegg | hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| kegg | hsa05166 | HTLV-I infection - Homo sapiens (human) |
| kegg | hsa05167 | Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human) |
| kegg | hsa05168 | Herpes simplex infection - Homo sapiens (human) |
| kegg | hsa05169 | Epstein-Barr virus infection - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05202 | Transcriptional misregulation in cancer - Homo sapiens (human) |
| kegg | hsa05203 | Viral carcinogenesis - Homo sapiens (human) |
| kegg | hsa05212 | Pancreatic cancer - Homo sapiens (human) |
| kegg | hsa05215 | Prostate cancer - Homo sapiens (human) |
| kegg | hsa05220 | Chronic myeloid leukemia - Homo sapiens (human) |
| kegg | hsa05221 | Acute myeloid leukemia - Homo sapiens (human) |
| kegg | hsa05222 | Small cell lung cancer - Homo sapiens (human) |
| kegg | hsa05321 | Inflammatory bowel disease (IBD) - Homo sapiens (human) |
| kegg | hsa05418 | Fluid shear stress and atherosclerosis - Homo sapiens (human) |
| biocarta | 41bbpathway | the 41bb-dependent immune response |
| biocarta | aktpathway | akt signaling pathway |
| biocarta | atmpathway | atm signaling pathway |
| biocarta | cardiacegfpathway | role of egf receptor transactivation by gpcrs in cardiac hypertrophy |
| biocarta | cd40pathway | cd40l signaling pathway |
| biocarta | cdmacpathway | cadmium induces dna synthesis and proliferation in macrophages |
| biocarta | ceramidepathway | ceramide signaling pathway |
| biocarta | eponfkbpathway | erythropoietin mediated neuroprotection through nf-kb |
| biocarta | fmlppathway | fmlp induced chemokine gene expression in hmc-1 cells |
| biocarta | gcrpathway | corticosteroids and cardioprotection |
| biocarta | gsk3pathway | inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages |
| biocarta | hcmvpathway | human cytomegalovirus and map kinase pathways |
| biocarta | hivnefpathway | hiv-1 nef: negative effector of fas and tnf |
| biocarta | il1rpathway | signal transduction through il1r |
| biocarta | keratinocytepathway | keratinocyte differentiation |
| biocarta | nfkbpathway | nf-kb signaling pathway |
| biocarta | nthipathway | nfkb activation by nontypeable hemophilus influenzae |
| biocarta | pcafpathway | the information processing pathway at the ifn beta enhancer |
| biocarta | pparapathway | mechanism of gene regulation by peroxisome proliferators via ppara |
| biocarta | raccycdpathway | influence of ras and rho proteins on g1 to s transition |
| biocarta | ranklpathway | bone remodeling |
| biocarta | relapathway | acetylation and deacetylation of rela in nucleus |
| biocarta | rnapathway | double stranded rna induced gene expression |
| biocarta | tcrpathway | t cell receptor signaling pathway |
| biocarta | tffpathway | trefoil factors initiate mucosal healing |
| biocarta | tidpathway | chaperones modulate interferon signaling pathway |
| biocarta | tnfr2pathway | tnfr2 signaling pathway |
| biocarta | tollpathway | toll-like receptor pathway |
| reactome | R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) |
| reactome | R-HSA-1169091 | Activation of NF-kappaB in B cells |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade |
| reactome | R-HSA-166058 | MyD88:Mal cascade initiated on plasma membrane |
| reactome | R-HSA-166166 | MyD88-independent TLR4 cascade |
| reactome | R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade |
| reactome | R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade |
| reactome | R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade |
| reactome | R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade |
| reactome | R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade |
| reactome | R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade |
| reactome | R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways |
| reactome | R-HSA-168898 | Toll-Like Receptors Cascades |
| reactome | R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta |
| reactome | R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 |
| reactome | R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade |
| reactome | R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA |
| reactome | R-HSA-193639 | p75NTR signals via NF-kB |
| reactome | R-HSA-193692 | Regulated proteolysis of p75NTR |
| reactome | R-HSA-193704 | p75 NTR receptor-mediated signalling |
| reactome | R-HSA-202403 | TCR signaling |
| reactome | R-HSA-202424 | Downstream TCR signaling |
| reactome | R-HSA-209560 | NF-kB is activated and signals survival |
| reactome | R-HSA-2262752 | Cellular responses to stress |
| reactome | R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling |
| reactome | R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) |
| reactome | R-HSA-2559583 | Cellular Senescence |
| reactome | R-HSA-2871837 | FCERI mediated NF-kB activation |
| reactome | R-HSA-2990846 | SUMOylation |
| reactome | R-HSA-3108232 | SUMO E3 ligases SUMOylate target proteins |
| reactome | R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production |
| reactome | R-HSA-3214841 | PKMTs methylate histone lysines |
| reactome | R-HSA-3247509 | Chromatin modifying enzymes |
| reactome | R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-445989 | TAK1 activates NFkB by phosphorylation and activation of IKKs complex |
| reactome | R-HSA-446652 | Interleukin-1 family signaling |
| reactome | R-HSA-448706 | Interleukin-1 processing |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-4755510 | SUMOylation of immune response proteins |
| reactome | R-HSA-4839726 | Chromatin organization |
| reactome | R-HSA-5260271 | Diseases of Immune System |
| reactome | R-HSA-5602358 | Diseases associated with the TLR signaling cascade |
| reactome | R-HSA-5603029 | IkBA variant leads to EDA-ID |
| reactome | R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling |
| reactome | R-HSA-5607764 | CLEC7A (Dectin-1) signaling |
| reactome | R-HSA-5621481 | C-type lectin receptors (CLRs) |
| reactome | R-HSA-5621575 | CD209 (DC-SIGN) signaling |
| reactome | R-HSA-5660668 | CLEC7A/inflammasome pathway |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-622312 | Inflammasomes |
| reactome | R-HSA-73887 | Death Receptor Signalling |
| reactome | R-HSA-844456 | The NLRP3 inflammasome |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
| reactome | R-HSA-9020702 | Interleukin-1 signaling |
| reactome | R-HSA-933542 | TRAF6 mediated NF-kB activation |
| reactome | R-HSA-937061 | TRIF(TICAM1)-mediated TLR4 signaling |
| reactome | R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
| reactome | R-HSA-975155 | MyD88 dependent cascade initiated on endosome |
| reactome | R-HSA-975871 | MyD88 cascade initiated on plasma membrane |
| reactome | R-HSA-983705 | Signaling by the B Cell Receptor (BCR) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD60 | Quinoclamine | 3 |
| iGMDRD23 | Gossypol | 1 |
| iGMDRD356 | PNU-74654 | 2 |
| iGMDRD451 | Serdemetan | 1 |
| iGMDRD100 | Zebularine | 3 |
| iGMDRD74 | Idarubicin | 4 |
| iGMDRD562 | Navitoclax | 2 |
| iGMDRD782 | DC-45-A2 | 2 |
| iGMDRD318 | PAC-1 | 1 |
| iGMDRD255 | SB225002 | 2 |
| iGMDRD802 | 4-methylfasudil | 3 |
| iGMDRD297 | Austocystin D | 5 |
| iGMDRD679 | Bistramide A | 1 |
| iGMDRD152 | 179324-69-7 | 1 |
| iGMDRD546 | BMS-754807 | 2 |
| iGMDRD144 | NSC95397 | 2 |
| iGMDRD494 | Neopeltolide | 4 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD126 | Tipifarnib | 2 |
| iGMDRD151 | CHM-1 | 2 |
| iGMDRD420 | Leucascandrolide A | 2 |
| iGMDRD300 | Tozasertib | 3 |
| iGMDRD42 | Vorinostat | 2 |
| iGMDRD367 | Ro 28-1675 | 2 |
| iGMDRD871 | BRD6368 | 2 |
| iGMDRD286 | Nsc 632839 | 2 |
| iGMDRD414 | MST-312 | 6 |
| iGMDRD329 | Merck60 | 4 |
| iGMDRD366 | PI-103 | 3 |
| iGMDRD103 | SN-38 | 2 |
| iGMDRD271 | Brefeldin A | 5 |
| iGMDRD158 | NSC141540 | 2 |
| iGMDRD177 | Teniposide | 4 |
| iGMDRD154 | NSC23766 | 4 |
| iGMDRD351 | GW843682X | 4 |
| iGMDRD57 | Chloropentafluorobenzene | 2 |
| iGMDRD314 | Tanespimycin | 1 |
| iGMDRD116 | CD437 | 5 |
| iGMDRD405 | PIK-75 | 3 |
| iGMDRD512 | nutlin 3 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RELA
CLASSFICATION
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Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.