RELA


Summary: NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
RELA proto-oncogene, NF-kB subunitMIM:164014Ensembl:ENSG00000173039HGNC:HGNC:9955PA29611q13.1

GO terms in RELA


Term TypeEvidence TypeGO Term IDGO Des.
CCIDAGO:0000790nuclear chromatin
CCIDAGO:0005634nucleus
CCIMPGO:0005634nucleus
CCIBAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCIDAGO:0005667transcription factor complex
CCIDAGO:0005730nucleolus
CCIDAGO:0005737cytoplasm
CCIBAGO:0005829cytosol
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
CCIBAGO:0033256I-kappaB/NF-kappaB complex
CCIDAGO:0035525NF-kappaB p50/p65 complex
BPIBAGO:0000122negative regulation of transcription by RNA polymerase II
BPIDAGO:0000122negative regulation of transcription by RNA polymerase II
BPIEAGO:0001889liver development
BPIEAGO:0001942hair follicle development
BPTASGO:0002223stimulatory C-type lectin receptor signaling pathway
BPIEAGO:0006117acetaldehyde metabolic process
BPIMPGO:0006355regulation of transcription, DNA-templated
BPIBAGO:0006954inflammatory response
BPIDAGO:0006954inflammatory response
BPNASGO:0006968cellular defense response
BPIBAGO:0007249I-kappaB kinase/NF-kappaB signaling
BPIEAGO:0007568aging
BPIDAGO:0008284positive regulation of cell proliferation
BPIEAGO:0009887animal organ morphogenesis
BPIDAGO:0010033response to organic substance
BPIDAGO:0010224response to UV-B
BPIEAGO:0014040positive regulation of Schwann cell differentiation
BPIEAGO:0016032viral process
BPIDAGO:0019221cytokine-mediated signaling pathway
BPTASGO:0031293membrane protein intracellular domain proteolysis
BPIEAGO:0032332positive regulation of chondrocyte differentiation
BPTASGO:0032481positive regulation of type I interferon production
BPIEAGO:0032495response to muramyl dipeptide
BPIEAGO:0032570response to progesterone
BPIEAGO:0032868response to insulin
BPIDAGO:0033209tumor necrosis factor-mediated signaling pathway
BPIEAGO:0033234negative regulation of protein sumoylation
BPIEAGO:0033590response to cobalamin
BPIBAGO:0034097response to cytokine
BPIEAGO:0035729cellular response to hepatocyte growth factor stimulus
BPIMPGO:0035924cellular response to vascular endothelial growth factor stimulus
BPIEAGO:0035994response to muscle stretch
BPIBAGO:0038061NIK/NF-kappaB signaling
BPTASGO:0038095Fc-epsilon receptor signaling pathway
BPIEAGO:0042177negative regulation of protein catabolic process
BPIDAGO:0043066negative regulation of apoptotic process
BPTASGO:0043066negative regulation of apoptotic process
BPIEPGO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling
BPIEAGO:0043200response to amino acid
BPIEAGO:0043278response to morphine
BPIMPGO:0043620regulation of DNA-templated transcription in response to stress
BPIEAGO:0045084positive regulation of interleukin-12 biosynthetic process
BPIBAGO:0045087innate immune response
BPIDAGO:0045892negative regulation of transcription, DNA-templated
BPIDAGO:0045893positive regulation of transcription, DNA-templated
BPIMPGO:0045893positive regulation of transcription, DNA-templated
BPIBAGO:0045944positive regulation of transcription by RNA polymerase II
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
BPIMPGO:0045944positive regulation of transcription by RNA polymerase II
BPIEAGO:0046627negative regulation of insulin receptor signaling pathway
BPISSGO:0050727regulation of inflammatory response
BPTASGO:0050852T cell receptor signaling pathway
BPIMPGO:0050862positive regulation of T cell receptor signaling pathway
BPIDAGO:0051092positive regulation of NF-kappaB transcription factor activity
BPIGIGO:0051092positive regulation of NF-kappaB transcription factor activity
BPIMPGO:0051092positive regulation of NF-kappaB transcription factor activity
BPTASGO:0051092positive regulation of NF-kappaB transcription factor activity
BPIEAGO:0051591response to cAMP
BPNASGO:0051607defense response to virus
BPIMPGO:0061614pri-miRNA transcription by RNA polymerase II
BPIDAGO:0070301cellular response to hydrogen peroxide
BPIDAGO:0070431nucleotide-binding oligomerization domain containing 2 signaling pathway
BPTASGO:0070498interleukin-1-mediated signaling pathway
BPIGIGO:0070555response to interleukin-1
BPIEAGO:0071222cellular response to lipopolysaccharide
BPIMPGO:0071223cellular response to lipoteichoic acid
BPIMPGO:0071224cellular response to peptidoglycan
BPIMPGO:0071316cellular response to nicotine
BPIDAGO:0071347cellular response to interleukin-1
BPIMPGO:0071354cellular response to interleukin-6
BPIDAGO:0071356cellular response to tumor necrosis factor
BPIMPGO:0071356cellular response to tumor necrosis factor
BPIGIGO:1901222regulation of NIK/NF-kappaB signaling
BPIMPGO:1901223negative regulation of NIK/NF-kappaB signaling
BPIDAGO:1901224positive regulation of NIK/NF-kappaB signaling
BPIMPGO:1901224positive regulation of NIK/NF-kappaB signaling
BPIMPGO:1901522positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
BPIMPGO:1902894negative regulation of pri-miRNA transcription by RNA polymerase II
BPIMPGO:1902895positive regulation of pri-miRNA transcription by RNA polymerase II
BPIMPGO:1904385cellular response to angiotensin
BPIMPGO:2000630positive regulation of miRNA metabolic process
BPIMPGO:2001237negative regulation of extrinsic apoptotic signaling pathway
MFIBAGO:0000977RNA polymerase II regulatory region sequence-specific DNA binding
MFIDAGO:0000977RNA polymerase II regulatory region sequence-specific DNA binding
MFIMPGO:0000977RNA polymerase II regulatory region sequence-specific DNA binding
MFIDAGO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding
MFIDAGO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding
MFIBAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIMPGO:0000983transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding
MFIDAGO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MFIDAGO:0001078transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MFIDAGO:0001205transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding
MFIDAGO:0003677DNA binding
MFIMPGO:0003677DNA binding
MFIBAGO:0003682chromatin binding
MFIDAGO:0003682chromatin binding
MFIDAGO:0003700DNA-binding transcription factor activity
MFIMPGO:0003700DNA-binding transcription factor activity
MFIDAGO:0003705transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
MFIPIGO:0005515protein binding
MFIPIGO:0008134transcription factor binding
MFIPIGO:0019901protein kinase binding
MFIDAGO:0031490chromatin DNA binding
MFIPIGO:0031625ubiquitin protein ligase binding
MFIPIGO:0033613activating transcription factor binding
MFIDAGO:0042301phosphate ion binding
MFIDAGO:0042802identical protein binding
MFIPIGO:0042802identical protein binding
MFIDAGO:0042803protein homodimerization activity
MFIPIGO:0042805actinin binding
MFIPIGO:0042826histone deacetylase binding
MFIDAGO:0044212transcription regulatory region DNA binding
MFIEAGO:0044877protein-containing complex binding
MFIDAGO:0046982protein heterodimerization activity
MFIPIGO:0047485protein N-terminus binding
MFIPIGO:0051059NF-kappaB binding
MFIPIGO:0070491repressing transcription factor binding
MFIEAGO:0071532ankyrin repeat binding

Gene expression in normal tissue: RELA

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in RELA


DatabasePathway IDPathway Des.
wikipathwaysWP138Androgen receptor signaling pathway
wikipathwaysWP1433Nucleotide-binding Oligomerization Domain (NOD) pathway
wikipathwaysWP1434Osteopontin Signaling
wikipathwaysWP1449Regulation of toll-like receptor signaling pathway
wikipathwaysWP15Selenium Micronutrient Network
wikipathwaysWP1533Vitamin B12 Metabolism
wikipathwaysWP176Folate Metabolism
wikipathwaysWP195IL-1 signaling pathway
wikipathwaysWP2018RANKL-RANK (Receptor activator of NFKB (ligand)) Signaling Pathway
wikipathwaysWP2034Leptin signaling pathway
wikipathwaysWP2036TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway
wikipathwaysWP2037Prolactin Signaling Pathway
wikipathwaysWP2112IL17 signaling pathway
wikipathwaysWP2203Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway
wikipathwaysWP23B Cell Receptor Signaling Pathway
wikipathwaysWP2324AGE-RAGE pathway
wikipathwaysWP2332Interleukin-11 Signaling Pathway
wikipathwaysWP2355Corticotropin-releasing hormone signaling pathway
wikipathwaysWP2374Oncostatin M Signaling Pathway
wikipathwaysWP2380Brain-Derived Neurotrophic Factor (BDNF) signaling pathway
wikipathwaysWP254Apoptosis
wikipathwaysWP2586Aryl Hydrocarbon Receptor
wikipathwaysWP262EBV LMP1 signaling
wikipathwaysWP2637Structural Pathway of Interleukin 1 (IL-1)
wikipathwaysWP28Selenium Metabolism and Selenoproteins
wikipathwaysWP288NLR Proteins
wikipathwaysWP3303Rac1-Pak1-p38-MMP-2 pathway
wikipathwaysWP3414Initiation of transcription and translation elongation at the HIV-1 LTR
wikipathwaysWP3617Photodynamic therapy-induced NF-kB survival signaling
wikipathwaysWP3639Apoptotic Signaling Pathway
wikipathwaysWP382MAPK Signaling Pathway
wikipathwaysWP3858Toll-like Receptor Signaling
wikipathwaysWP3865RIG-I-like Receptor Signaling
wikipathwaysWP3888VEGFA-VEGFR2 Signaling Pathway
wikipathwaysWP3926ApoE and miR-146 in inflammation and atherosclerosis
wikipathwaysWP3929Chemokine signaling pathway
wikipathwaysWP395IL-4 Signaling Pathway
wikipathwaysWP4008NO-cGMP-PKG mediated Neuroprotection
wikipathwaysWP4141PI3K-AKT-mTOR - VitD3 Signalling
wikipathwaysWP4172PI3K-Akt Signaling Pathway
wikipathwaysWP4223Ras Signaling
wikipathwaysWP69T-Cell antigen Receptor (TCR) Signaling Pathway
wikipathwaysWP75Toll-like Receptor Signaling Pathway
netpathPathway_BCRBCR
netpathPathway_BDNFBDNF
netpathPathway_CRHCRH
netpathPathway_EGFR1EGFR1
netpathPathway_GastrinGastrin
netpathPathway_GhrelinGhrelin
netpathPathway_IL1IL1
netpathPathway_IL11IL11
netpathPathway_IL2IL2
netpathPathway_KitReceptorKitReceptor
netpathPathway_NotchNotch
netpathPathway_Oncostatin_MOncostatin_M
netpathPathway_ProlactinProlactin
netpathPathway_RAGERAGE
netpathPathway_TCRTCR
netpathPathway_TNFalphaTNFalpha
netpathPathway_TSLPTSLP
netpathPathway_TWEAKTWEAK
pidangiopoietinreceptor_pathwayAngiopoietin receptor Tie2-mediated signaling
pidavb3_opn_pathwayOsteopontin-mediated events
pidbcr_5pathwayBCR signaling pathway
pidcd40_pathwayCD40/CD40L signaling
pidceramide_pathwayCeramide signaling pathway
pidfcer1pathwayFc-epsilon receptor I signaling in mast cells
pidhdac_classi_pathwaySignaling events mediated by HDAC Class I
pidhivnefpathwayHIV-1 Nef: Negative effector of Fas and TNF-alpha
pidil12_2pathwayIL12-mediated signaling events
pidil1pathwayIL1-mediated signaling events
pidil23pathwayIL23-mediated signaling events
pidil2_pi3kpathwayIL2 signaling events mediated by PI3K
pidlysophospholipid_pathwayLPA receptor mediated events
pidnfkappabatypicalpathwayAtypical NF-kappaB pathway
pidnfkappabcanonicalpathwayCanonical NF-kappaB pathway
pidp73pathwayp73 transcription factor network
pidreg_gr_pathwayGlucocorticoid receptor regulatory network
pidtnfpathwayTNF receptor signaling pathway
pharmgkbPA162356267EGFR Inhibitor Pathway, Pharmacodynamics
pharmgkbPA165985892Tacrolimus/Cyclosporine Pathway, Pharmacodynamics
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa04014Ras signaling pathway - Homo sapiens (human)
kegghsa04024cAMP signaling pathway - Homo sapiens (human)
kegghsa04062Chemokine signaling pathway - Homo sapiens (human)
kegghsa04064NF-kappa B signaling pathway - Homo sapiens (human)
kegghsa04066HIF-1 signaling pathway - Homo sapiens (human)
kegghsa04071Sphingolipid signaling pathway - Homo sapiens (human)
kegghsa04137Mitophagy - animal - Homo sapiens (human)
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa04210Apoptosis - Homo sapiens (human)
kegghsa04211Longevity regulating pathway - Homo sapiens (human)
kegghsa04218Cellular senescence - Homo sapiens (human)
kegghsa04380Osteoclast differentiation - Homo sapiens (human)
kegghsa04620Toll-like receptor signaling pathway - Homo sapiens (human)
kegghsa04621NOD-like receptor signaling pathway - Homo sapiens (human)
kegghsa04622RIG-I-like receptor signaling pathway - Homo sapiens (human)
kegghsa04623Cytosolic DNA-sensing pathway - Homo sapiens (human)
kegghsa04625C-type lectin receptor signaling pathway - Homo sapiens (human)
kegghsa04657IL-17 signaling pathway - Homo sapiens (human)
kegghsa04658Th1 and Th2 cell differentiation - Homo sapiens (human)
kegghsa04659Th17 cell differentiation - Homo sapiens (human)
kegghsa04660T cell receptor signaling pathway - Homo sapiens (human)
kegghsa04662B cell receptor signaling pathway - Homo sapiens (human)
kegghsa04668TNF signaling pathway - Homo sapiens (human)
kegghsa04722Neurotrophin signaling pathway - Homo sapiens (human)
kegghsa04917Prolactin signaling pathway - Homo sapiens (human)
kegghsa04920Adipocytokine signaling pathway - Homo sapiens (human)
kegghsa04926Relaxin signaling pathway - Homo sapiens (human)
kegghsa04931Insulin resistance - Homo sapiens (human)
kegghsa04932Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human)
kegghsa04933AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)
kegghsa05030Cocaine addiction - Homo sapiens (human)
kegghsa05120Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human)
kegghsa05131Shigellosis - Homo sapiens (human)
kegghsa05132Salmonella infection - Homo sapiens (human)
kegghsa05133Pertussis - Homo sapiens (human)
kegghsa05134Legionellosis - Homo sapiens (human)
kegghsa05140Leishmaniasis - Homo sapiens (human)
kegghsa05142Chagas disease (American trypanosomiasis) - Homo sapiens (human)
kegghsa05145Toxoplasmosis - Homo sapiens (human)
kegghsa05146Amoebiasis - Homo sapiens (human)
kegghsa05152Tuberculosis - Homo sapiens (human)
kegghsa05160Hepatitis C - Homo sapiens (human)
kegghsa05161Hepatitis B - Homo sapiens (human)
kegghsa05162Measles - Homo sapiens (human)
kegghsa05164Influenza A - Homo sapiens (human)
kegghsa05165Human papillomavirus infection - Homo sapiens (human)
kegghsa05166HTLV-I infection - Homo sapiens (human)
kegghsa05167Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human)
kegghsa05168Herpes simplex infection - Homo sapiens (human)
kegghsa05169Epstein-Barr virus infection - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05202Transcriptional misregulation in cancer - Homo sapiens (human)
kegghsa05203Viral carcinogenesis - Homo sapiens (human)
kegghsa05212Pancreatic cancer - Homo sapiens (human)
kegghsa05215Prostate cancer - Homo sapiens (human)
kegghsa05220Chronic myeloid leukemia - Homo sapiens (human)
kegghsa05221Acute myeloid leukemia - Homo sapiens (human)
kegghsa05222Small cell lung cancer - Homo sapiens (human)
kegghsa05321Inflammatory bowel disease (IBD) - Homo sapiens (human)
kegghsa05418Fluid shear stress and atherosclerosis - Homo sapiens (human)
biocarta41bbpathwaythe 41bb-dependent immune response
biocartaaktpathwayakt signaling pathway
biocartaatmpathwayatm signaling pathway
biocartacardiacegfpathwayrole of egf receptor transactivation by gpcrs in cardiac hypertrophy
biocartacd40pathwaycd40l signaling pathway
biocartacdmacpathwaycadmium induces dna synthesis and proliferation in macrophages
biocartaceramidepathwayceramide signaling pathway
biocartaeponfkbpathwayerythropoietin mediated neuroprotection through nf-kb
biocartafmlppathwayfmlp induced chemokine gene expression in hmc-1 cells
biocartagcrpathwaycorticosteroids and cardioprotection
biocartagsk3pathwayinactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages
biocartahcmvpathwayhuman cytomegalovirus and map kinase pathways
biocartahivnefpathwayhiv-1 nef: negative effector of fas and tnf
biocartail1rpathwaysignal transduction through il1r
biocartakeratinocytepathwaykeratinocyte differentiation
biocartanfkbpathwaynf-kb signaling pathway
biocartanthipathwaynfkb activation by nontypeable hemophilus influenzae
biocartapcafpathwaythe information processing pathway at the ifn beta enhancer
biocartapparapathwaymechanism of gene regulation by peroxisome proliferators via ppara
biocartaraccycdpathwayinfluence of ras and rho proteins on g1 to s transition
biocartaranklpathwaybone remodeling
biocartarelapathwayacetylation and deacetylation of rela in nucleus
biocartarnapathwaydouble stranded rna induced gene expression
biocartatcrpathwayt cell receptor signaling pathway
biocartatffpathwaytrefoil factors initiate mucosal healing
biocartatidpathwaychaperones modulate interferon signaling pathway
biocartatnfr2pathwaytnfr2 signaling pathway
biocartatollpathwaytoll-like receptor pathway
reactomeR-HSA-1168372Downstream signaling events of B Cell Receptor (BCR)
reactomeR-HSA-1169091Activation of NF-kappaB in B cells
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-1606322ZBP1(DAI) mediated induction of type I IFNs
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1643685Disease
reactomeR-HSA-166016Toll Like Receptor 4 (TLR4) Cascade
reactomeR-HSA-166058MyD88:Mal cascade initiated on plasma membrane
reactomeR-HSA-166166MyD88-independent TLR4 cascade
reactomeR-HSA-168138Toll Like Receptor 9 (TLR9) Cascade
reactomeR-HSA-168142Toll Like Receptor 10 (TLR10) Cascade
reactomeR-HSA-168164Toll Like Receptor 3 (TLR3) Cascade
reactomeR-HSA-168176Toll Like Receptor 5 (TLR5) Cascade
reactomeR-HSA-168179Toll Like Receptor TLR1:TLR2 Cascade
reactomeR-HSA-168181Toll Like Receptor 7/8 (TLR7/8) Cascade
reactomeR-HSA-168188Toll Like Receptor TLR6:TLR2 Cascade
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-168643Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
reactomeR-HSA-168898Toll-Like Receptors Cascades
reactomeR-HSA-168928DDX58/IFIH1-mediated induction of interferon-alpha/beta
reactomeR-HSA-1810476RIP-mediated NFkB activation via ZBP1
reactomeR-HSA-181438Toll Like Receptor 2 (TLR2) Cascade
reactomeR-HSA-1834949Cytosolic sensors of pathogen-associated DNA
reactomeR-HSA-193639p75NTR signals via NF-kB
reactomeR-HSA-193692Regulated proteolysis of p75NTR
reactomeR-HSA-193704p75 NTR receptor-mediated signalling
reactomeR-HSA-202403TCR signaling
reactomeR-HSA-202424Downstream TCR signaling
reactomeR-HSA-209560NF-kB is activated and signals survival
reactomeR-HSA-2262752Cellular responses to stress
reactomeR-HSA-2454202Fc epsilon receptor (FCERI) signaling
reactomeR-HSA-2559582Senescence-Associated Secretory Phenotype (SASP)
reactomeR-HSA-2559583Cellular Senescence
reactomeR-HSA-2871837FCERI mediated NF-kB activation
reactomeR-HSA-2990846SUMOylation
reactomeR-HSA-3108232SUMO E3 ligases SUMOylate target proteins
reactomeR-HSA-3134963DEx/H-box helicases activate type I IFN and inflammatory cytokines production
reactomeR-HSA-3214841PKMTs methylate histone lysines
reactomeR-HSA-3247509Chromatin modifying enzymes
reactomeR-HSA-381340Transcriptional regulation of white adipocyte differentiation
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-445989TAK1 activates NFkB by phosphorylation and activation of IKKs complex
reactomeR-HSA-446652Interleukin-1 family signaling
reactomeR-HSA-448706Interleukin-1 processing
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-4755510SUMOylation of immune response proteins
reactomeR-HSA-4839726Chromatin organization
reactomeR-HSA-5260271Diseases of Immune System
reactomeR-HSA-5602358Diseases associated with the TLR signaling cascade
reactomeR-HSA-5603029IkBA variant leads to EDA-ID
reactomeR-HSA-5607761Dectin-1 mediated noncanonical NF-kB signaling
reactomeR-HSA-5607764CLEC7A (Dectin-1) signaling
reactomeR-HSA-5621481C-type lectin receptors (CLRs)
reactomeR-HSA-5621575CD209 (DC-SIGN) signaling
reactomeR-HSA-5660668CLEC7A/inflammasome pathway
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-622312Inflammasomes
reactomeR-HSA-73887Death Receptor Signalling
reactomeR-HSA-844456The NLRP3 inflammasome
reactomeR-HSA-8953897Cellular responses to external stimuli
reactomeR-HSA-9020702Interleukin-1 signaling
reactomeR-HSA-933542TRAF6 mediated NF-kB activation
reactomeR-HSA-937061TRIF(TICAM1)-mediated TLR4 signaling
reactomeR-HSA-975138TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
reactomeR-HSA-975155MyD88 dependent cascade initiated on endosome
reactomeR-HSA-975871MyD88 cascade initiated on plasma membrane
reactomeR-HSA-983705Signaling by the B Cell Receptor (BCR)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD60Quinoclamine3
iGMDRD23Gossypol1
iGMDRD356PNU-746542
iGMDRD451Serdemetan1
iGMDRD100Zebularine3
iGMDRD74Idarubicin4
iGMDRD562Navitoclax2
iGMDRD782DC-45-A22
iGMDRD318PAC-11
iGMDRD255SB2250022
iGMDRD8024-methylfasudil3
iGMDRD297Austocystin D5
iGMDRD679Bistramide A1
iGMDRD152179324-69-71
iGMDRD546BMS-7548072
iGMDRD144NSC953972
iGMDRD494Neopeltolide4
iGMDRD781Sirolimus3
iGMDRD126Tipifarnib2
iGMDRD151CHM-12
iGMDRD420Leucascandrolide A2
iGMDRD300Tozasertib3
iGMDRD42Vorinostat2
iGMDRD367Ro 28-16752
iGMDRD871BRD63682
iGMDRD286Nsc 6328392
iGMDRD414MST-3126
iGMDRD329Merck604
iGMDRD366PI-1033
iGMDRD103SN-382
iGMDRD271Brefeldin A5
iGMDRD158NSC1415402
iGMDRD177Teniposide4
iGMDRD154NSC237664
iGMDRD351GW843682X4
iGMDRD57Chloropentafluorobenzene2
iGMDRD314Tanespimycin1
iGMDRD116CD4375
iGMDRD405PIK-753
iGMDRD512nutlin 32

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RELA

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