CASP6


Summary: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family of enzymes. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic acid residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of this gene results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Oct 2015].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
caspase 6MIM:601532Ensembl:ENSG00000138794HGNC:HGNC:1507PA260904q25

Gene Categories:

PROTEASEDRUGGABLE GENOME

GO terms in CASP6


Term TypeEvidence TypeGO Term IDGO Des.
MFTASGO:0004197cysteine-type endopeptidase activity
MFIPIGO:0005515protein binding
MFTASGO:0008234cysteine-type peptidase activity
MFIPIGO:0042802identical protein binding
MFIBAGO:0097153cysteine-type endopeptidase activity involved in apoptotic process
MFIMPGO:0097200cysteine-type endopeptidase activity involved in execution phase of apoptosis
BPIDAGO:0006508proteolysis
BPIBAGO:0006915apoptotic process
BPTASGO:0006915apoptotic process
BPIEPGO:0030855epithelial cell differentiation
BPTASGO:0042981regulation of apoptotic process
BPIMPGO:0072734cellular response to staurosporine
BPTASGO:0097194execution phase of apoptosis
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCIBAGO:0005737cytoplasm
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol

Gene expression in normal tissue: CASP6

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CASP6


DatabasePathway IDPathway Des.
pidcaspase_pathwayCaspase Cascade in Apoptosis
pidcmyb_pathwayC-MYB transcription factor network
pidhivnefpathwayHIV-1 Nef: Negative effector of Fas and TNF-alpha
pidp53downstreampathwayDirect p53 effectors
pidp75ntrpathwayp75(NTR)-mediated signaling
kegghsa04210Apoptosis - Homo sapiens (human)
wikipathwaysWP1772Apoptosis Modulation and Signaling
wikipathwaysWP2371Parkinsons Disease Pathway
wikipathwaysWP2507Nanomaterial induced apoptosis
wikipathwaysWP2512Integrated Lung Cancer Pathway
wikipathwaysWP254Apoptosis
wikipathwaysWP314Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation
wikipathwaysWP3639Apoptotic Signaling Pathway
wikipathwaysWP3802TP53 Regulates Transcription of Cell Death Genes
wikipathwaysWP384Apoptosis Modulation by HSP70
reactomeR-HSA-109581Apoptosis
reactomeR-HSA-111465Apoptotic cleavage of cellular proteins
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-264870Caspase-mediated cleavage of cytoskeletal proteins
reactomeR-HSA-352238Breakdown of the nuclear lamina
reactomeR-HSA-3700989Transcriptional Regulation by TP53
reactomeR-HSA-5357801Programmed Cell Death
reactomeR-HSA-5633008TP53 Regulates Transcription of Cell Death Genes
reactomeR-HSA-6803207TP53 Regulates Transcription of Caspase Activators and Caspases
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-75153Apoptotic execution phase
biocartacaspasepathwaycaspase cascade in apoptosis
biocartachemicalpathwayapoptotic signaling in response to dna damage
biocartadeathpathwayinduction of apoptosis through dr3 and dr4/5 death receptors
biocartahivnefpathwayhiv-1 nef: negative effector of fas and tnf
biocartairespathwayinternal ribosome entry pathway
biocartaplk3pathwayregulation of cell cycle progression by plk3
biocartatffpathwaytrefoil factors initiate mucosal healing
biocartawnvpathwaywest nile virus

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD137Indisulam3
iGMDRD158NSC1415403
iGMDRD871BRD63683
iGMDRD730Kahalalide F3
iGMDRD74Idarubicin3
iGMDRD506Fedratinib3
iGMDRD300Tozasertib3
iGMDRD23Gossypol3
iGMDRD444Tivantinib3
iGMDRD126Tipifarnib3
iGMDRD512nutlin 33
iGMDRD532Olaparib3
iGMDRD424Tamatinib3
iGMDRD639YK 4-2793
iGMDRD901ELCPK3
iGMDRD280CYTOCHALASIN B3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CASP6

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