CASP6
Summary: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family of enzymes. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic acid residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of this gene results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Oct 2015].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
Namecaspase 6 OMIM IDMIM:601532 Ensembl IDEnsembl:ENSG00000138794 HGNC IDHGNC:HGNC:1507 PHARMGKB IDPA26090 Map Location4q25 | |||||
GO terms in CASP6
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0004197 | cysteine-type endopeptidase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | TAS | GO:0008234 | cysteine-type peptidase activity |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IBA | GO:0097153 | cysteine-type endopeptidase activity involved in apoptotic process |
| MF | IMP | GO:0097200 | cysteine-type endopeptidase activity involved in execution phase of apoptosis |
Gene expression in normal tissue: CASP6
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CASP6
Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | caspase_pathway | Caspase Cascade in Apoptosis |
| pid | cmyb_pathway | C-MYB transcription factor network |
| pid | hivnefpathway | HIV-1 Nef: Negative effector of Fas and TNF-alpha |
| pid | p53downstreampathway | Direct p53 effectors |
| pid | p75ntrpathway | p75(NTR)-mediated signaling |
| kegg | hsa04210 | Apoptosis - Homo sapiens (human) |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CASP6
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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