CASP6
Summary: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family of enzymes. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic acid residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of this gene results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Oct 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| caspase 6 | MIM:601532 | Ensembl:ENSG00000138794 | HGNC:HGNC:1507 | PA26090 | 4q25 |
GO terms in CASP6
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0004197 | cysteine-type endopeptidase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | TAS | GO:0008234 | cysteine-type peptidase activity |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IBA | GO:0097153 | cysteine-type endopeptidase activity involved in apoptotic process |
| MF | IMP | GO:0097200 | cysteine-type endopeptidase activity involved in execution phase of apoptosis |
| BP | IDA | GO:0006508 | proteolysis |
| BP | IBA | GO:0006915 | apoptotic process |
| BP | TAS | GO:0006915 | apoptotic process |
| BP | IEP | GO:0030855 | epithelial cell differentiation |
| BP | TAS | GO:0042981 | regulation of apoptotic process |
| BP | IMP | GO:0072734 | cellular response to staurosporine |
| BP | TAS | GO:0097194 | execution phase of apoptosis |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
Gene expression in normal tissue: CASP6
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CASP6
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | caspase_pathway | Caspase Cascade in Apoptosis |
| pid | cmyb_pathway | C-MYB transcription factor network |
| pid | hivnefpathway | HIV-1 Nef: Negative effector of Fas and TNF-alpha |
| pid | p53downstreampathway | Direct p53 effectors |
| pid | p75ntrpathway | p75(NTR)-mediated signaling |
| kegg | hsa04210 | Apoptosis - Homo sapiens (human) |
| wikipathways | WP1772 | Apoptosis Modulation and Signaling |
| wikipathways | WP2371 | Parkinsons Disease Pathway |
| wikipathways | WP2507 | Nanomaterial induced apoptosis |
| wikipathways | WP2512 | Integrated Lung Cancer Pathway |
| wikipathways | WP254 | Apoptosis |
| wikipathways | WP314 | Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation |
| wikipathways | WP3639 | Apoptotic Signaling Pathway |
| wikipathways | WP3802 | TP53 Regulates Transcription of Cell Death Genes |
| wikipathways | WP384 | Apoptosis Modulation by HSP70 |
| reactome | R-HSA-109581 | Apoptosis |
| reactome | R-HSA-111465 | Apoptotic cleavage of cellular proteins |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins |
| reactome | R-HSA-352238 | Breakdown of the nuclear lamina |
| reactome | R-HSA-3700989 | Transcriptional Regulation by TP53 |
| reactome | R-HSA-5357801 | Programmed Cell Death |
| reactome | R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes |
| reactome | R-HSA-6803207 | TP53 Regulates Transcription of Caspase Activators and Caspases |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-75153 | Apoptotic execution phase |
| biocarta | caspasepathway | caspase cascade in apoptosis |
| biocarta | chemicalpathway | apoptotic signaling in response to dna damage |
| biocarta | deathpathway | induction of apoptosis through dr3 and dr4/5 death receptors |
| biocarta | hivnefpathway | hiv-1 nef: negative effector of fas and tnf |
| biocarta | irespathway | internal ribosome entry pathway |
| biocarta | plk3pathway | regulation of cell cycle progression by plk3 |
| biocarta | tffpathway | trefoil factors initiate mucosal healing |
| biocarta | wnvpathway | west nile virus |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD137 | Indisulam | 3 |
| iGMDRD158 | NSC141540 | 3 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD730 | Kahalalide F | 3 |
| iGMDRD74 | Idarubicin | 3 |
| iGMDRD506 | Fedratinib | 3 |
| iGMDRD300 | Tozasertib | 3 |
| iGMDRD23 | Gossypol | 3 |
| iGMDRD444 | Tivantinib | 3 |
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD532 | Olaparib | 3 |
| iGMDRD424 | Tamatinib | 3 |
| iGMDRD639 | YK 4-279 | 3 |
| iGMDRD901 | ELCPK | 3 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CASP6
CLASSFICATION
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