EWSR1


Summary: This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a t(11;22)(q24;q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14. [provided by RefSeq, Jul 2009].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
EWS RNA binding protein 1MIM:133450Ensembl:ENSG00000182944HGNC:HGNC:3508PA2792122q12.2

GO terms in EWSR1


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0003712transcription coregulator activity
MFHDAGO:0003723RNA binding
MFIPIGO:0005515protein binding
MFIEAGO:0005516calmodulin binding
MFIPIGO:0042802identical protein binding
MFIEAGO:0046872metal ion binding
CCIBAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCIDAGO:0005730nucleolus
CCIEAGO:0005737cytoplasm
CCIEAGO:0005886plasma membrane
BPIEAGO:0006351transcription, DNA-templated
BPIEAGO:0006355regulation of transcription, DNA-templated

Gene expression in normal tissue: EWSR1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in EWSR1


DatabasePathway IDPathway Des.
pidbard1pathwayBARD1 signaling events
netpathPathway_TGF_beta_ReceptorTGF_beta_Receptor
kegghsa05202Transcriptional misregulation in cancer - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD639YK 4-2792
iGMDRD280CYTOCHALASIN B4
iGMDRD901ELCPK2
iGMDRD154NSC237662
iGMDRD132(-)-gallocatechin-3-O-gallate2
iGMDRD554CHEMBL14341372
iGMDRD126Tipifarnib4
iGMDRD512nutlin 32
iGMDRD424Tamatinib2
iGMDRD532Olaparib2
iGMDRD79Gemcitabine2
iGMDRD730Kahalalide F2
iGMDRD74Idarubicin2
iGMDRD871BRD63682
iGMDRD780PP-301
iGMDRD506Fedratinib2
iGMDRD300Tozasertib2
iGMDRD444Tivantinib2
iGMDRD268Cerulenin2
iGMDRD23Gossypol2
iGMDRD158NSC1415403
iGMDRD137Indisulam2
iGMDRD270Ciclosporin3
iGMDRD434BMS-5369243
iGMDRD294Batimastat2
iGMDRD226ML0062
iGMDRD318PAC-13

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in EWSR1

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