COLEC11


Summary: This gene encodes a member of the collectin family of C-type lectins that possess collagen-like sequences and carbohydrate recognition domains. Collectins are secreted proteins that play important roles in the innate immune system by binding to carbohydrate antigens on microorganisms, facilitating their recognition and removal. The encoded protein binds to multiple sugars with a preference for fucose and mannose. Mutations in this gene are a cause of 3MC syndrome-2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
collectin subfamily member 11MIM:612502Ensembl:ENSG00000118004HGNC:HGNC:17213PA267372p25.3

Gene Categories:

PROTEASE

GO terms in COLEC11


Term TypeEvidence TypeGO Term IDGO Des.
CCTASGO:0005576extracellular region
CCIEAGO:0005581collagen trimer
CCIBAGO:0005615extracellular space
CCIDAGO:0005615extracellular space
BPIMPGO:0001867complement activation, lectin pathway
BPTASGO:0001867complement activation, lectin pathway
BPIEAGO:0006508proteolysis
BPTASGO:0006898receptor-mediated endocytosis
BPIDAGO:0006956complement activation
BPTASGO:0006956complement activation
BPIEAGO:0007275multicellular organism development
BPIDAGO:0019730antimicrobial humoral response
BPIBAGO:0032502developmental process
BPISSGO:0032502developmental process
BPICGO:0097194execution phase of apoptosis
MFIDAGO:0003677DNA binding
MFTASGO:0004252serine-type endopeptidase activity
MFIDAGO:0005509calcium ion binding
MFIPIGO:0005515protein binding
MFIDAGO:0005537mannose binding
MFIDAGO:0042806fucose binding
MFIBAGO:0048029monosaccharide binding
MFIDAGO:0070492oligosaccharide binding
MFIDAGO:0120153calcium-dependent carbohydrate binding

Gene expression in normal tissue: COLEC11

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in COLEC11


DatabasePathway IDPathway Des.
wikipathwaysWP2877Vitamin D Receptor Pathway
kegghsa04145Phagosome - Homo sapiens (human)
reactomeR-HSA-166658Complement cascade
reactomeR-HSA-166662Lectin pathway of complement activation
reactomeR-HSA-166663Initial triggering of complement
reactomeR-HSA-166786Creation of C4 and C2 activators
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-2173782Binding and Uptake of Ligands by Scavenger Receptors
reactomeR-HSA-3000480Scavenging by Class A Receptors
reactomeR-HSA-5653656Vesicle-mediated transport

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD451Serdemetan4
iGMDRD268Cerulenin2
iGMDRD23Gossypol2
iGMDRD356PNU-746542
iGMDRD60Quinoclamine2
iGMDRD398Sepantronium2
iGMDRD562Navitoclax2
iGMDRD577BIX012942
iGMDRD74Idarubicin1
iGMDRD887Compound 23 citrate2
iGMDRD294Batimastat2
iGMDRD187BRD98761
iGMDRD870BRD636103
iGMDRD52Rotenone5
iGMDRD8012,4-dideoxy-DC-45-A22
iGMDRD171Pemetrexed4
iGMDRD8024-methylfasudil2
iGMDRD375GW-4058332
iGMDRD280CYTOCHALASIN B2
iGMDRD466Chaetocin3
iGMDRD61Kinetin riboside2
iGMDRD772BRD47702
iGMDRD599Salermide2
iGMDRD126Tipifarnib5
iGMDRD322FK 8663
iGMDRD147Prima-12
iGMDRD246NPC262
iGMDRD329Merck601
iGMDRD872BRD71372
iGMDRD286Nsc 6328392
iGMDRD871BRD63682
iGMDRD213SMR0000686502
iGMDRD434BMS-5369241
iGMDRD289Parthenolide2
iGMDRD5Tyrphostin AG 14781
iGMDRD158NSC1415402
iGMDRD121GMX17783
iGMDRD154NSC237664
iGMDRD901ELCPK2
iGMDRD314Tanespimycin1
iGMDRD85Ursolic acid2
iGMDRD512nutlin 35
iGMDRD330BRD41323

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in COLEC11

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