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COLEC11

Summary: This gene encodes a member of the collectin family of C-type lectins that possess collagen-like sequences and carbohydrate recognition domains. Collectins are secreted proteins that play important roles in the innate immune system by binding to carbohydrate antigens on microorganisms, facilitating their recognition and removal. The encoded protein binds to multiple sugars with a preference for fucose and mannose. Mutations in this gene are a cause of 3MC syndrome-2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
collectin subfamily member 11	MIM:612502	Ensembl:ENSG00000118004	HGNC:HGNC:17213	PA26737	2p25.3

Gene Categories:

PROTEASE

GO terms in COLEC11

Term Type	Evidence Type	GO Term ID	GO Des.
CC	TAS	GO:0005576	extracellular region
CC	IEA	GO:0005581	collagen trimer
CC	IBA	GO:0005615	extracellular space
CC	IDA	GO:0005615	extracellular space
BP	IMP	GO:0001867	complement activation, lectin pathway
BP	TAS	GO:0001867	complement activation, lectin pathway
BP	IEA	GO:0006508	proteolysis
BP	TAS	GO:0006898	receptor-mediated endocytosis
BP	IDA	GO:0006956	complement activation
BP	TAS	GO:0006956	complement activation
BP	IEA	GO:0007275	multicellular organism development
BP	IDA	GO:0019730	antimicrobial humoral response
BP	IBA	GO:0032502	developmental process
BP	ISS	GO:0032502	developmental process
BP	IC	GO:0097194	execution phase of apoptosis
MF	IDA	GO:0003677	DNA binding
MF	TAS	GO:0004252	serine-type endopeptidase activity
MF	IDA	GO:0005509	calcium ion binding
MF	IPI	GO:0005515	protein binding
MF	IDA	GO:0005537	mannose binding
MF	IDA	GO:0042806	fucose binding
MF	IBA	GO:0048029	monosaccharide binding
MF	IDA	GO:0070492	oligosaccharide binding
MF	IDA	GO:0120153	calcium-dependent carbohydrate binding

Gene expression in normal tissue: COLEC11

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in COLEC11

Database	Pathway ID	Pathway Des.
wikipathways	WP2877	Vitamin D Receptor Pathway
kegg	hsa04145	Phagosome - Homo sapiens (human)
reactome	R-HSA-166658	Complement cascade
reactome	R-HSA-166662	Lectin pathway of complement activation
reactome	R-HSA-166663	Initial triggering of complement
reactome	R-HSA-166786	Creation of C4 and C2 activators
reactome	R-HSA-168249	Innate Immune System
reactome	R-HSA-168256	Immune System
reactome	R-HSA-2173782	Binding and Uptake of Ligands by Scavenger Receptors
reactome	R-HSA-3000480	Scavenging by Class A Receptors
reactome	R-HSA-5653656	Vesicle-mediated transport

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD451	Serdemetan	4
iGMDRD268	Cerulenin	2
iGMDRD23	Gossypol	2
iGMDRD356	PNU-74654	2
iGMDRD60	Quinoclamine	2
iGMDRD398	Sepantronium	2
iGMDRD562	Navitoclax	2
iGMDRD577	BIX01294	2
iGMDRD74	Idarubicin	1
iGMDRD887	Compound 23 citrate	2
iGMDRD294	Batimastat	2
iGMDRD187	BRD9876	1
iGMDRD870	BRD63610	3
iGMDRD52	Rotenone	5
iGMDRD801	2,4-dideoxy-DC-45-A2	2
iGMDRD171	Pemetrexed	4
iGMDRD802	4-methylfasudil	2
iGMDRD375	GW-405833	2
iGMDRD280	CYTOCHALASIN B	2
iGMDRD466	Chaetocin	3
iGMDRD61	Kinetin riboside	2
iGMDRD772	BRD4770	2
iGMDRD599	Salermide	2
iGMDRD126	Tipifarnib	5
iGMDRD322	FK 866	3
iGMDRD147	Prima-1	2
iGMDRD246	NPC26	2
iGMDRD329	Merck60	1
iGMDRD872	BRD7137	2
iGMDRD286	Nsc 632839	2
iGMDRD871	BRD6368	2
iGMDRD213	SMR000068650	2
iGMDRD434	BMS-536924	1
iGMDRD289	Parthenolide	2
iGMDRD5	Tyrphostin AG 1478	1
iGMDRD158	NSC141540	2
iGMDRD121	GMX1778	3
iGMDRD154	NSC23766	4
iGMDRD901	ELCPK	2
iGMDRD314	Tanespimycin	1
iGMDRD85	Ursolic acid	2
iGMDRD512	nutlin 3	5
iGMDRD330	BRD4132	3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in COLEC11

SITE

DATATYPES

CLASSFICATION

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