TMPO
Summary: The protein encoded by this gene resides in the nucleus and may play a role in the assembly of the nuclear lamina, and thus help maintain the structural organization of the nuclear envelope. It may function as a receptor for the attachment of lamin filaments to the inner nuclear membrane. Mutations in this gene are associated with dilated cardiomyopathy. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, May 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| thymopoietin | MIM:188380 | Ensembl:ENSG00000120802 | HGNC:HGNC:11875 | PA36576 | 12q23.1 |
GO terms in TMPO
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0003677 | DNA binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | TAS | GO:0005521 | lamin binding |
| MF | HDA | GO:0045296 | cadherin binding |
| BP | IEA | GO:0006355 | regulation of transcription, DNA-templated |
| CC | IDA | GO:0000785 | chromatin |
| CC | IDA | GO:0005634 | nucleus |
| CC | IEA | GO:0005635 | nuclear envelope |
Gene expression in normal tissue: TMPO
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TMPO
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-2555396 | Mitotic Metaphase and Anaphase |
| reactome | R-HSA-2980766 | Nuclear Envelope Breakdown |
| reactome | R-HSA-2993913 | Clearance of Nuclear Envelope Membranes from Chromatin |
| reactome | R-HSA-2995383 | Initiation of Nuclear Envelope Reformation |
| reactome | R-HSA-2995410 | Nuclear Envelope Reassembly |
| reactome | R-HSA-4419969 | Depolymerisation of the Nuclear Lamina |
| reactome | R-HSA-68875 | Mitotic Prophase |
| reactome | R-HSA-68882 | Mitotic Anaphase |
| reactome | R-HSA-68886 | M Phase |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD271 | Brefeldin A | 3 |
| iGMDRD121 | GMX1778 | 3 |
| iGMDRD68 | Paclitaxel | 1 |
| iGMDRD441 | TW 37 | 1 |
| iGMDRD171 | Pemetrexed | 3 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD74 | Idarubicin | 3 |
| iGMDRD887 | Compound 23 citrate | 3 |
| iGMDRD322 | FK 866 | 3 |
| iGMDRD505 | Pevonedistat | 6 |
| iGMDRD300 | Tozasertib | 3 |
| iGMDRD579 | PF750 | 6 |
| iGMDRD494 | Neopeltolide | 3 |
| iGMDRD483 | SCH-529074 | 3 |
| iGMDRD701 | NVP-AUY922 | 3 |
| iGMDRD150 | RITA | 3 |
| iGMDRD546 | BMS-754807 | 3 |
| iGMDRD424 | Tamatinib | 4 |
| iGMDRD71 | Sparfosic acid | 3 |
| iGMDRD154 | NSC23766 | 4 |
| iGMDRD123 | Isoevodiamine | 1 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD466 | Chaetocin | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TMPO
CLASSFICATION
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