MCF2
Summary: The oncogenic protein encoded by this gene is a guanine nucleotide exchange factor (GEF) that exerts control over some members of the Rho family of small GTPases. Several transcript variants encoding different isoforms have been found for this gene. These isoforms exhibit different expression patterns and varying levels of GEF activity.[provided by RefSeq, Jan 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| MCF.2 cell line derived transforming sequence | MIM:311030 | Ensembl:ENSG00000101977 | HGNC:HGNC:6940 | PA30684 | Xq27.1 |
GO terms in MCF2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0005085 | guanyl-nucleotide exchange factor activity |
| MF | TAS | GO:0005089 | Rho guanyl-nucleotide exchange factor activity |
| MF | IPI | GO:0005515 | protein binding |
| BP | TAS | GO:0007186 | G-protein coupled receptor signaling pathway |
| BP | IEA | GO:0035023 | regulation of Rho protein signal transduction |
| BP | IEA | GO:0035556 | intracellular signal transduction |
| BP | TAS | GO:0043065 | positive regulation of apoptotic process |
| BP | TAS | GO:0050771 | negative regulation of axonogenesis |
| BP | TAS | GO:0051056 | regulation of small GTPase mediated signal transduction |
| CC | TAS | GO:0005829 | cytosol |
| CC | TAS | GO:0005856 | cytoskeleton |
| CC | IEA | GO:0016020 | membrane |
Gene expression in normal tissue: MCF2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MCF2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-193634 | Axonal growth inhibition (RHOA activation) |
| reactome | R-HSA-193648 | NRAGE signals death through JNK |
| reactome | R-HSA-193697 | p75NTR regulates axonogenesis |
| reactome | R-HSA-193704 | p75 NTR receptor-mediated signalling |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-194840 | Rho GTPase cycle |
| reactome | R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-416482 | G alpha (12/13) signalling events |
| reactome | R-HSA-73887 | Death Receptor Signalling |
| netpath | Pathway_EGFR1 | EGFR1 |
| pid | cdc42_reg_pathway | Regulation of CDC42 activity |
| pid | rac1_reg_pathway | Regulation of RAC1 activity |
| pid | rhoa_reg_pathway | Regulation of RhoA activity |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD219 | Bax channel blocker | 2 |
| iGMDRD193 | Fqi1 | 2 |
| iGMDRD237 | ABT-751 | 2 |
| iGMDRD57 | Chloropentafluorobenzene | 1 |
| iGMDRD639 | YK 4-279 | 2 |
| iGMDRD280 | CYTOCHALASIN B | 8 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD901 | ELCPK | 3 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 3 |
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD560 | MK-2206 | 2 |
| iGMDRD405 | PIK-75 | 2 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD74 | Idarubicin | 5 |
| iGMDRD100 | Zebularine | 2 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD329 | Merck60 | 5 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD322 | FK 866 | 3 |
| iGMDRD524 | ISX-9 | 5 |
| iGMDRD158 | NSC141540 | 3 |
| iGMDRD137 | Indisulam | 1 |
| iGMDRD255 | SB225002 | 4 |
| iGMDRD802 | 4-methylfasudil | 5 |
| iGMDRD782 | DC-45-A2 | 2 |
| iGMDRD294 | Batimastat | 1 |
| iGMDRD77 | Itraconazole | 3 |
| iGMDRD870 | BRD63610 | 3 |
| iGMDRD187 | BRD9876 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MCF2
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.