MCF2
Summary: The oncogenic protein encoded by this gene is a guanine nucleotide exchange factor (GEF) that exerts control over some members of the Rho family of small GTPases. Several transcript variants encoding different isoforms have been found for this gene. These isoforms exhibit different expression patterns and varying levels of GEF activity.[provided by RefSeq, Jan 2010].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:311030 Ensembl IDEnsembl:ENSG00000101977 HGNC IDHGNC:HGNC:6940 PHARMGKB IDPA30684 Map LocationXq27.1 |
GO terms in MCF2
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Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | TAS | GO:0005085 | guanyl-nucleotide exchange factor activity |
MF | TAS | GO:0005089 | Rho guanyl-nucleotide exchange factor activity |
MF | IPI | GO:0005515 | protein binding |
BP | TAS | GO:0007186 | G-protein coupled receptor signaling pathway |
BP | IEA | GO:0035023 | regulation of Rho protein signal transduction |
BP | IEA | GO:0035556 | intracellular signal transduction |
Gene expression in normal tissue: MCF2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MCF2
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Database | Pathway ID | Pathway Des. |
---|---|---|
reactome | R-HSA-162582 | Signal Transduction |
reactome | R-HSA-193634 | Axonal growth inhibition (RHOA activation) |
reactome | R-HSA-193648 | NRAGE signals death through JNK |
reactome | R-HSA-193697 | p75NTR regulates axonogenesis |
reactome | R-HSA-193704 | p75 NTR receptor-mediated signalling |
reactome | R-HSA-194315 | Signaling by Rho GTPases |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in MCF2
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
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No matching records found |