MCF2

Summary: The oncogenic protein encoded by this gene is a guanine nucleotide exchange factor (GEF) that exerts control over some members of the Rho family of small GTPases. Several transcript variants encoding different isoforms have been found for this gene. These isoforms exhibit different expression patterns and varying levels of GEF activity.[provided by RefSeq, Jan 2010].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameMCF.2 cell line derived transforming sequence
OMIM IDMIM:311030
Ensembl IDEnsembl:ENSG00000101977
HGNC IDHGNC:HGNC:6940
PHARMGKB IDPA30684
Map LocationXq27.1

GO terms in MCF2


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Term Type
Evidence Type
GO Term ID
GO Des.
MF TAS GO:0005085 guanyl-nucleotide exchange factor activity
MF TAS GO:0005089 Rho guanyl-nucleotide exchange factor activity
MF IPI GO:0005515 protein binding
BP TAS GO:0007186 G-protein coupled receptor signaling pathway
BP IEA GO:0035023 regulation of Rho protein signal transduction
BP IEA GO:0035556 intracellular signal transduction
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Gene expression in normal tissue: MCF2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined24Leukocyte transendothelial migration1DNA replication1Longevity regulating pathway1PI3K/MTOR signaling1Metabolism1

Pathways in MCF2


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Database
Pathway ID
Pathway Des.
reactome R-HSA-162582 Signal Transduction
reactome R-HSA-193634 Axonal growth inhibition (RHOA activation)
reactome R-HSA-193648 NRAGE signals death through JNK
reactome R-HSA-193697 p75NTR regulates axonogenesis
reactome R-HSA-193704 p75 NTR receptor-mediated signalling
reactome R-HSA-194315 Signaling by Rho GTPases
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD219 Bax channel blocker 2
iGMDRD193 Fqi1 2
iGMDRD237 ABT-751 2
iGMDRD57 Chloropentafluorobenzene 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MCF2

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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