SLK
Summary:
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| STE20 like kinase | MIM:616563 | Ensembl:ENSG00000065613 | HGNC:HGNC:11088 | PA35941 | 10q24.33-q25.1 |
GO terms in SLK
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IDA | GO:0042803 | protein homodimerization activity |
| MF | HDA | GO:0045296 | cadherin binding |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | ISS | GO:0031252 | cell leading edge |
| CC | IDA | GO:0048471 | perinuclear region of cytoplasm |
| CC | HDA | GO:0070062 | extracellular exosome |
| BP | IEA | GO:0006915 | apoptotic process |
| BP | IBA | GO:0007346 | regulation of mitotic cell cycle |
| BP | IBA | GO:0023014 | signal transduction by protein phosphorylation |
| BP | IMP | GO:0030334 | regulation of cell migration |
| BP | ISS | GO:0030334 | regulation of cell migration |
| BP | IMP | GO:0031122 | cytoplasmic microtubule organization |
| BP | IBA | GO:0032147 | activation of protein kinase activity |
| BP | IDA | GO:0042981 | regulation of apoptotic process |
| BP | IDA | GO:0046777 | protein autophosphorylation |
| BP | IDA | GO:0051893 | regulation of focal adhesion assembly |
Gene expression in normal tissue: SLK
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SLK
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04114 | Oocyte meiosis - Homo sapiens (human) |
| pid | caspase_pathway | Caspase Cascade in Apoptosis |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD77 | Itraconazole | 4 |
| iGMDRD6 | AM-580 | 2 |
| iGMDRD171 | Pemetrexed | 2 |
| iGMDRD434 | BMS-536924 | 6 |
| iGMDRD255 | SB225002 | 2 |
| iGMDRD138 | PX 12 | 3 |
| iGMDRD137 | Indisulam | 2 |
| iGMDRD202 | Curcumin | 6 |
| iGMDRD23 | Gossypol | 3 |
| iGMDRD524 | ISX-9 | 1 |
| iGMDRD60 | Quinoclamine | 2 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD329 | Merck60 | 1 |
| iGMDRD562 | Navitoclax | 6 |
| iGMDRD74 | Idarubicin | 2 |
| iGMDRD462 | OSI-906 (Linsitinib) | 1 |
| iGMDRD546 | BMS-754807 | 2 |
| iGMDRD670 | ML 210 | 1 |
| iGMDRD433 | Lexibulin | 3 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD466 | Chaetocin | 1 |
| iGMDRD394 | BX-795 | 2 |
| iGMDRD639 | YK 4-279 | 2 |
| iGMDRD57 | Chloropentafluorobenzene | 1 |
| iGMDRD193 | Fqi1 | 5 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD201 | SKI II | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SLK
CLASSFICATION
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