GRK1

Summary: This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates rhodopsin and initiates its deactivation. Defects in GRK1 are known to cause Oguchi disease 2 (also known as stationary night blindness Oguchi type-2). [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameG protein-coupled receptor kinase 1
OMIM IDMIM:180381
Ensembl IDEnsembl:ENSG00000185974
HGNC IDHGNC:HGNC:10013
PHARMGKB IDPA34391
Map Location13q34

GO terms in GRK1


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Term Type
Evidence Type
GO Term ID
GO Des.
CC TAS GO:0097381 photoreceptor disc membrane
BP IEA GO:0007601 visual perception
BP TAS GO:0008277 regulation of G-protein coupled receptor protein signaling pathway
BP TAS GO:0016056 rhodopsin mediated signaling pathway
BP IDA GO:0022400 regulation of rhodopsin mediated signaling pathway
BP TAS GO:0022400 regulation of rhodopsin mediated signaling pathway
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Gene expression in normal tissue: GRK1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined22Chromatin histone acetylation1Leukocyte transendothelial migration1Biosynthesis of secondary metabolites1One carbon pool by folate1p53 pathway1Protein stability and degradation1Chromatin other1Other, kinases1DNA replication1

Pathways in GRK1


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Database
Pathway ID
Pathway Des.
reactome R-HSA-162582 Signal Transduction
reactome R-HSA-162582 Signal Transduction
reactome R-HSA-2187338 Visual phototransduction
reactome R-HSA-2187338 Visual phototransduction
reactome R-HSA-2514856 The phototransduction cascade
reactome R-HSA-2514856 The phototransduction cascade
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD85 Ursolic acid 1
iGMDRD193 Fqi1 1
iGMDRD314 Tanespimycin 1
iGMDRD280 CYTOCHALASIN B 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

13undefined2MDM21TOP21HMGCS11JAK21DHFR1MMP161NFKB11IGF1R1EHMT2

Gene Structure: PDB

Models in GRK1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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