GRK1
Summary: This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates rhodopsin and initiates its deactivation. Defects in GRK1 are known to cause Oguchi disease 2 (also known as stationary night blindness Oguchi type-2). [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| G protein-coupled receptor kinase 1 | MIM:180381 | Ensembl:ENSG00000185974 | HGNC:HGNC:10013 | PA34391 | 13q34 |
GO terms in GRK1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0097381 | photoreceptor disc membrane |
| BP | IEA | GO:0007601 | visual perception |
| BP | TAS | GO:0008277 | regulation of G-protein coupled receptor protein signaling pathway |
| BP | TAS | GO:0016056 | rhodopsin mediated signaling pathway |
| BP | IDA | GO:0022400 | regulation of rhodopsin mediated signaling pathway |
| BP | TAS | GO:0022400 | regulation of rhodopsin mediated signaling pathway |
| BP | IMP | GO:0046777 | protein autophosphorylation |
| MF | TAS | GO:0004672 | protein kinase activity |
| MF | IEA | GO:0004703 | G-protein coupled receptor kinase activity |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IDA | GO:0050254 | rhodopsin kinase activity |
| MF | TAS | GO:0050254 | rhodopsin kinase activity |
Gene expression in normal tissue: GRK1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in GRK1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-2187338 | Visual phototransduction |
| reactome | R-HSA-2187338 | Visual phototransduction |
| reactome | R-HSA-2514856 | The phototransduction cascade |
| reactome | R-HSA-2514856 | The phototransduction cascade |
| reactome | R-HSA-2514859 | Inactivation, recovery and regulation of the phototransduction cascade |
| reactome | R-HSA-2514859 | Inactivation, recovery and regulation of the phototransduction cascade |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-418594 | G alpha (i) signalling events |
| reactome | R-HSA-418594 | G alpha (i) signalling events |
| biocarta | rhodopsinpathway | visual signal transduction |
| kegg | hsa04062 | Chemokine signaling pathway - Homo sapiens (human) |
| kegg | hsa04144 | Endocytosis - Homo sapiens (human) |
| kegg | hsa04744 | Phototransduction - Homo sapiens (human) |
| pid | cone_pathway | Visual signal transduction: Cones |
| pid | rhodopsin_pathway | Visual signal transduction: Rods |
| wikipathways | WP3929 | Chemokine signaling pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD85 | Ursolic acid | 1 |
| iGMDRD193 | Fqi1 | 1 |
| iGMDRD314 | Tanespimycin | 1 |
| iGMDRD280 | CYTOCHALASIN B | 2 |
| iGMDRD466 | Chaetocin | 2 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 3 |
| iGMDRD154 | NSC23766 | 6 |
| iGMDRD375 | GW-405833 | 2 |
| iGMDRD330 | BRD4132 | 5 |
| iGMDRD599 | Salermide | 2 |
| iGMDRD512 | nutlin 3 | 1 |
| iGMDRD424 | Tamatinib | 2 |
| iGMDRD405 | PIK-75 | 1 |
| iGMDRD483 | SCH-529074 | 2 |
| iGMDRD494 | Neopeltolide | 4 |
| iGMDRD74 | Idarubicin | 1 |
| iGMDRD662 | JQ-1 | 2 |
| iGMDRD577 | BIX01294 | 2 |
| iGMDRD506 | Fedratinib | 5 |
| iGMDRD60 | Quinoclamine | 7 |
| iGMDRD451 | Serdemetan | 3 |
| iGMDRD268 | Cerulenin | 3 |
| iGMDRD158 | NSC141540 | 2 |
| iGMDRD802 | 4-methylfasudil | 2 |
| iGMDRD171 | Pemetrexed | 2 |
| iGMDRD434 | BMS-536924 | 5 |
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD289 | Parthenolide | 2 |
| iGMDRD187 | BRD9876 | 4 |
| iGMDRD294 | Batimastat | 2 |
| iGMDRD52 | Rotenone | 4 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in GRK1
CLASSFICATION
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