RAG1
Summary: The protein encoded by this gene is involved in activation of immunoglobulin V-D-J recombination. The encoded protein is involved in recognition of the DNA substrate, but stable binding and cleavage activity also requires RAG2. Defects in this gene can be the cause of several diseases. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| recombination activating 1 | MIM:179615 | Ensembl:ENSG00000166349 | HGNC:HGNC:9831 | PA34185 | 11p12 |
GO terms in RAG1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0002250 | adaptive immune response |
| BP | ISS | GO:0002331 | pre-B cell allelic exclusion |
| BP | TAS | GO:0006310 | DNA recombination |
| BP | TAS | GO:0006955 | immune response |
| BP | IEA | GO:0008542 | visual learning |
| BP | ISS | GO:0010390 | histone monoubiquitination |
| BP | ISS | GO:0030183 | B cell differentiation |
| BP | ISS | GO:0033077 | T cell differentiation in thymus |
| BP | IMP | GO:0033151 | V(D)J recombination |
| BP | ISS | GO:0033151 | V(D)J recombination |
| BP | IEA | GO:0043029 | T cell homeostasis |
| BP | IEA | GO:0043154 | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| BP | IEA | GO:0045582 | positive regulation of T cell differentiation |
| BP | IEA | GO:0048538 | thymus development |
| BP | ISS | GO:0051865 | protein autoubiquitination |
| BP | IEA | GO:0070244 | negative regulation of thymocyte apoptotic process |
| BP | IEA | GO:0090305 | nucleic acid phosphodiester bond hydrolysis |
| BP | IEA | GO:2000822 | regulation of behavioral fear response |
| CC | ISS | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| MF | TAS | GO:0003677 | DNA binding |
| MF | ISS | GO:0004519 | endonuclease activity |
| MF | ISS | GO:0004842 | ubiquitin-protein transferase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | ISS | GO:0008270 | zinc ion binding |
| MF | ISS | GO:0042393 | histone binding |
| MF | ISS | GO:0042803 | protein homodimerization activity |
| MF | ISS | GO:0043565 | sequence-specific DNA binding |
| MF | ISS | GO:0046872 | metal ion binding |
| MF | IEA | GO:0061630 | ubiquitin protein ligase activity |
Gene expression in normal tissue: RAG1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RAG1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1266695 | Interleukin-7 signaling |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-5683057 | MAPK family signaling cascades |
| reactome | R-HSA-5687128 | MAPK6/MAPK4 signaling |
| wikipathways | WP3307 | MAPK6-MAPK4 signaling |
| kegg | hsa04068 | FoxO signaling pathway - Homo sapiens (human) |
| kegg | hsa05340 | Primary immunodeficiency - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD297 | Austocystin D | 3 |
| iGMDRD446 | LY 2183240 | 4 |
| iGMDRD494 | Neopeltolide | 3 |
| iGMDRD424 | Tamatinib | 3 |
| iGMDRD546 | BMS-754807 | 3 |
| iGMDRD772 | BRD4770 | 3 |
| iGMDRD780 | PP-30 | 1 |
| iGMDRD888 | Compound 44 | 1 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD74 | Idarubicin | 3 |
| iGMDRD871 | BRD6368 | 4 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD187 | BRD9876 | 3 |
| iGMDRD267 | Oligomycin A | 6 |
| iGMDRD885 | Compound 110 | 3 |
| iGMDRD202 | Curcumin | 3 |
| iGMDRD137 | Indisulam | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RAG1
CLASSFICATION
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