RAG1

Summary: The protein encoded by this gene is involved in activation of immunoglobulin V-D-J recombination. The encoded protein is involved in recognition of the DNA substrate, but stable binding and cleavage activity also requires RAG2. Defects in this gene can be the cause of several diseases. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namerecombination activating 1
OMIM IDMIM:179615
Ensembl IDEnsembl:ENSG00000166349
HGNC IDHGNC:HGNC:9831
PHARMGKB IDPA34185
Map Location11p12

GO terms in RAG1


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IEA GO:0002250 adaptive immune response
BP ISS GO:0002331 pre-B cell allelic exclusion
BP TAS GO:0006310 DNA recombination
BP TAS GO:0006955 immune response
BP IEA GO:0008542 visual learning
BP ISS GO:0010390 histone monoubiquitination
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Gene expression in normal tissue: RAG1

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 22BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 8LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 4UTERUtissue: UTERU cancer: UTERUS model num: 0UTERUStissue: UTERUS cancer: Endometrial Carcinoma (UCEC) model num: 15BLOOtissue: BLOO cancer: BLOOD model num: 0BLOODtissue: BLOOD cancer: undefined model num: 6

Gene-drug pathway distribution

undefined16Stilbenoid, diarylheptanoid and gingerol biosynthesis1IGFR signaling1

Pathways in RAG1


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Database
Pathway ID
Pathway Des.
reactome R-HSA-1266695 Interleukin-7 signaling
reactome R-HSA-1280215 Cytokine Signaling in Immune system
reactome R-HSA-162582 Signal Transduction
reactome R-HSA-168256 Immune System
reactome R-HSA-449147 Signaling by Interleukins
reactome R-HSA-5683057 MAPK family signaling cascades
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD123 Isoevodiamine 3
iGMDRD297 Austocystin D 3
iGMDRD446 LY 2183240 4
iGMDRD494 Neopeltolide 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RAG1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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