RAG1


Summary: The protein encoded by this gene is involved in activation of immunoglobulin V-D-J recombination. The encoded protein is involved in recognition of the DNA substrate, but stable binding and cleavage activity also requires RAG2. Defects in this gene can be the cause of several diseases. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
recombination activating 1MIM:179615Ensembl:ENSG00000166349HGNC:HGNC:9831PA3418511p12

GO terms in RAG1


Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0002250adaptive immune response
BPISSGO:0002331pre-B cell allelic exclusion
BPTASGO:0006310DNA recombination
BPTASGO:0006955immune response
BPIEAGO:0008542visual learning
BPISSGO:0010390histone monoubiquitination
BPISSGO:0030183B cell differentiation
BPISSGO:0033077T cell differentiation in thymus
BPIMPGO:0033151V(D)J recombination
BPISSGO:0033151V(D)J recombination
BPIEAGO:0043029T cell homeostasis
BPIEAGO:0043154negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
BPIEAGO:0045582positive regulation of T cell differentiation
BPIEAGO:0048538thymus development
BPISSGO:0051865protein autoubiquitination
BPIEAGO:0070244negative regulation of thymocyte apoptotic process
BPIEAGO:0090305nucleic acid phosphodiester bond hydrolysis
BPIEAGO:2000822regulation of behavioral fear response
CCISSGO:0005634nucleus
CCTASGO:0005654nucleoplasm
MFTASGO:0003677DNA binding
MFISSGO:0004519endonuclease activity
MFISSGO:0004842ubiquitin-protein transferase activity
MFIPIGO:0005515protein binding
MFISSGO:0008270zinc ion binding
MFISSGO:0042393histone binding
MFISSGO:0042803protein homodimerization activity
MFISSGO:0043565sequence-specific DNA binding
MFISSGO:0046872metal ion binding
MFIEAGO:0061630ubiquitin protein ligase activity

Gene expression in normal tissue: RAG1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in RAG1


DatabasePathway IDPathway Des.
reactomeR-HSA-1266695Interleukin-7 signaling
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-168256Immune System
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-5683057MAPK family signaling cascades
reactomeR-HSA-5687128MAPK6/MAPK4 signaling
wikipathwaysWP3307MAPK6-MAPK4 signaling
kegghsa04068FoxO signaling pathway - Homo sapiens (human)
kegghsa05340Primary immunodeficiency - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD123Isoevodiamine3
iGMDRD297Austocystin D3
iGMDRD446LY 21832404
iGMDRD494Neopeltolide3
iGMDRD424Tamatinib3
iGMDRD546BMS-7548073
iGMDRD772BRD47703
iGMDRD780PP-301
iGMDRD888Compound 441
iGMDRD329Merck603
iGMDRD74Idarubicin3
iGMDRD871BRD63684
iGMDRD286Nsc 6328393
iGMDRD187BRD98763
iGMDRD267Oligomycin A6
iGMDRD885Compound 1103
iGMDRD202Curcumin3
iGMDRD137Indisulam3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RAG1

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