FEV
Summary: This gene belongs to the ETS transcription factor family. ETS family members have a highly conserved 85-amino acid ETS domain that binds purine-rich DNA sequences. The alanine-rich C-terminus of this gene indicates that it may act as a transcription repressor. This gene is exclusively expressed in neurons of the central serotonin (5-HT) system, a system implicated in the pathogeny of such psychiatric diseases as depression, anxiety, and eating disorders. In some types of Ewing tumors, this gene is fused to the Ewing sarcoma (EWS) gene following chromosome translocations. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| FEV, ETS transcription factor | MIM:607150 | Ensembl:ENSG00000163497 | HGNC:HGNC:18562 | PA134875093 | 2q35 |
GO terms in FEV
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | TAS | GO:0003700 | DNA-binding transcription factor activity |
| MF | TAS | GO:0003714 | transcription corepressor activity |
| MF | IEA | GO:0043565 | sequence-specific DNA binding |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0016607 | nuclear speck |
| BP | IBA | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | TAS | GO:0006366 | transcription by RNA polymerase II |
| BP | IEA | GO:0010628 | positive regulation of gene expression |
| BP | IBA | GO:0030154 | cell differentiation |
| BP | IEA | GO:0042551 | neuron maturation |
| BP | IEA | GO:0048665 | neuron fate specification |
| BP | IEA | GO:1903507 | negative regulation of nucleic acid-templated transcription |
Gene expression in normal tissue: FEV
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in FEV
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP706 | Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways |
| kegg | hsa05202 | Transcriptional misregulation in cancer - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD316 | N9-Isopropyl-olomoucine | 3 |
| iGMDRD201 | SKI II | 1 |
| iGMDRD579 | PF750 | 3 |
| iGMDRD772 | BRD4770 | 3 |
| iGMDRD356 | PNU-74654 | 1 |
| iGMDRD23 | Gossypol | 3 |
| iGMDRD82 | Quiflapon | 3 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD888 | Compound 44 | 3 |
| iGMDRD100 | Zebularine | 3 |
| iGMDRD74 | Idarubicin | 3 |
| iGMDRD887 | Compound 23 citrate | 3 |
| iGMDRD309 | 17AAG | 2 |
| iGMDRD52 | Rotenone | 3 |
| iGMDRD213 | SMR000068650 | 3 |
| iGMDRD270 | Ciclosporin | 3 |
| iGMDRD137 | Indisulam | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in FEV
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