GO terms in SMURF2


Term TypeEvidence TypeGO Term IDGO Des.
MFEXPGO:0004842ubiquitin-protein transferase activity
MFIDAGO:0004842ubiquitin-protein transferase activity
MFTASGO:0004842ubiquitin-protein transferase activity
MFIEAGO:0005160transforming growth factor beta receptor binding
MFIPIGO:0005515protein binding
MFIPIGO:0042802identical protein binding
MFIPIGO:0046332SMAD binding
MFIBAGO:0061630ubiquitin protein ligase activity
MFTASGO:0061630ubiquitin protein ligase activity
CCIDAGO:0000151ubiquitin ligase complex
CCNASGO:0005634nucleus
CCTASGO:0005654nucleoplasm
CCIBAGO:0005737cytoplasm
CCTASGO:0005829cytosol
CCIEAGO:0005886plasma membrane
CCIDAGO:0016607nuclear speck
CCIEAGO:0045121membrane raft
BPTASGO:0000122negative regulation of transcription by RNA polymerase II
BPIBAGO:0000209protein polyubiquitination
BPTASGO:0000209protein polyubiquitination
BPIDAGO:0006511ubiquitin-dependent protein catabolic process
BPIBAGO:0016567protein ubiquitination
BPTASGO:0016579protein deubiquitination
BPNASGO:0017015regulation of transforming growth factor beta receptor signaling pathway
BPTASGO:0030509BMP signaling pathway
BPIDAGO:0030512negative regulation of transforming growth factor beta receptor signaling pathway
BPTASGO:0030512negative regulation of transforming growth factor beta receptor signaling pathway
BPIBAGO:0030514negative regulation of BMP signaling pathway
BPIBAGO:0030579ubiquitin-dependent SMAD protein catabolic process
BPIDAGO:0030579ubiquitin-dependent SMAD protein catabolic process
BPIBAGO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process
BPIBAGO:0045732positive regulation of protein catabolic process
BPNASGO:0045892negative regulation of transcription, DNA-templated
BPTASGO:0060071Wnt signaling pathway, planar cell polarity pathway
BPTASGO:0090263positive regulation of canonical Wnt signaling pathway
BPIDAGO:1901165positive regulation of trophoblast cell migration

Gene expression in normal tissue: SMURF2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SMURF2


DatabasePathway IDPathway Des.
wikipathwaysWP366TGF-beta Signaling Pathway
wikipathwaysWP4249Hedgehog Signaling Pathway
netpathPathway_IDID
netpathPathway_TGF_beta_ReceptorTGF_beta_Receptor
pidbmppathwayBMP receptor signaling
pidtgfbrpathwayTGF-beta receptor signaling
humancycPWY66-11BMP Signalling Pathway
kegghsa04120Ubiquitin mediated proteolysis - Homo sapiens (human)
kegghsa04144Endocytosis - Homo sapiens (human)
kegghsa04340Hedgehog signaling pathway - Homo sapiens (human)
kegghsa04350TGF-beta signaling pathway - Homo sapiens (human)
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-168256Immune System
reactomeR-HSA-170834Signaling by TGF-beta Receptor Complex
reactomeR-HSA-170834Signaling by TGF-beta Receptor Complex
reactomeR-HSA-195721Signaling by WNT
reactomeR-HSA-201451Signaling by BMP
reactomeR-HSA-201681TCF dependent signaling in response to WNT
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-2173788Downregulation of TGF-beta receptor signaling
reactomeR-HSA-2173788Downregulation of TGF-beta receptor signaling
reactomeR-HSA-2173789TGF-beta receptor signaling activates SMADs
reactomeR-HSA-2173789TGF-beta receptor signaling activates SMADs
reactomeR-HSA-2173793Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
reactomeR-HSA-2173793Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
reactomeR-HSA-2173795Downregulation of SMAD2/3:SMAD4 transcriptional activity
reactomeR-HSA-2173795Downregulation of SMAD2/3:SMAD4 transcriptional activity
reactomeR-HSA-3858494Beta-catenin independent WNT signaling
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-4086400PCP/CE pathway
reactomeR-HSA-4608870Asymmetric localization of PCP proteins
reactomeR-HSA-4641257Degradation of AXIN
reactomeR-HSA-5358351Signaling by Hedgehog
reactomeR-HSA-5358351Signaling by Hedgehog
reactomeR-HSA-5632684Hedgehog 'on' state
reactomeR-HSA-5632684Hedgehog 'on' state
reactomeR-HSA-5688426Deubiquitination
reactomeR-HSA-5689880Ub-specific processing proteases
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-8878159Transcriptional regulation by RUNX3
reactomeR-HSA-8941858Regulation of RUNX3 expression and activity
reactomeR-HSA-9006936Signaling by TGF-beta family members
reactomeR-HSA-9006936Signaling by TGF-beta family members
reactomeR-HSA-983168Antigen processing: Ubiquitination & Proteasome degradation
reactomeR-HSA-983169Class I MHC mediated antigen processing & presentation

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD300Tozasertib2
iGMDRD552AZD-17755
iGMDRD263AACOCF35
iGMDRD871BRD63682
iGMDRD882CIL412
iGMDRD289Parthenolide5
iGMDRD434BMS-5369242
iGMDRD481Dactolisib2
iGMDRD202Curcumin5
iGMDRD251ML1623
iGMDRD5Tyrphostin AG 14785
iGMDRD945ML2141
iGMDRD698Neratinib5
iGMDRD532Olaparib2
iGMDRD424Tamatinib2
iGMDRD486Tosedostat5
iGMDRD512nutlin 32
iGMDRD60Quinoclamine2
iGMDRD23Gossypol2
iGMDRD444Tivantinib2
iGMDRD188Piperlongumine3
iGMDRD74Idarubicin3
iGMDRD730Kahalalide F3
iGMDRD506Fedratinib4
iGMDRD577BIX012943
iGMDRD562Navitoclax7
iGMDRD441TW 372
iGMDRD885Compound 1102
iGMDRD318PAC-12
iGMDRD138PX 122
iGMDRD255SB2250022
iGMDRD280CYTOCHALASIN B2
iGMDRD679Bistramide A1
iGMDRD639YK 4-2792
iGMDRD152179324-69-71
iGMDRD61Kinetin riboside2
iGMDRD144NSC953975
iGMDRD781Sirolimus4
iGMDRD126Tipifarnib4

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SMURF2

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