MAP3K7


Summary: The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location

GO terms in MAP3K7


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IEA GO:0000287 magnesium ion binding
MF IDA GO:0004672 protein kinase activity
MF EXP GO:0004674 protein serine/threonine kinase activity
MF TAS GO:0004674 protein serine/threonine kinase activity
MF EXP GO:0004709 MAP kinase kinase kinase activity
MF IBA GO:0004709 MAP kinase kinase kinase activity
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Gene expression in normal tissue: MAP3K7

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 28BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 13

Gene-drug pathway distribution

undefined10Leukocyte transendothelial migration1IGFR signaling1RTK signaling1Biosynthesis of secondary metabolites1Genome integrity1

Pathways in MAP3K7


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Database
Pathway ID
Pathway Des.
biocarta alkpathway alk in cardiac myocytes
biocarta faspathway fas signaling pathway (cd95)
biocarta il1rpathway signal transduction through il1r
biocarta mapkpathway mapkinase signaling pathway
biocarta nfkbpathway nf-kb signaling pathway
biocarta nthipathway nfkb activation by nontypeable hemophilus influenzae
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD123 Isoevodiamine 3
iGMDRD23 Gossypol 3
iGMDRD524 ISX-9 1
iGMDRD444 Tivantinib 3
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Gene in drug-gene network: Network Plot

KCNH2KCNH2NEK1NEK1PDCD1PDCD1HDAC2HDAC2PHIPPHIPTPH1TPH1CTNNA2CTNNA2FOXP1FOXP1PAX3PAX3LRGUKLRGUKHOXD13HOXD13PIK3CAPIK3CALRRK2LRRK2RORARORAPEAK1PEAK1WASWASGRIA3GRIA3IsoevodiamineIsoevodiamineLRRC7LRRC7TENM1TENM1PCDH15PCDH15MINK1MINK1AMER1AMER1CNTN5CNTN5EPHA6EPHA6TRAF6TRAF6PRAMEPRAMEDSTDSTHRASHRASGossypolGossypolMAP2K4MAP2K4ISX-9ISX-9PIK3R1PIK3R1TivantinibTivantinibMSH6MSH6LRP2LRP2COL14A1COL14A1BRIP1BRIP1SIK3SIK3CACNB2CACNB2ZFP69BZFP69BMAP4K2MAP4K2SOS1SOS1CNTRLCNTRLALPK2ALPK2GRK7GRK7JAG1JAG1LY 2183240LY 2183240MSH3MSH3MYCMYCDHFRDHFRPROCPROCKahalalide FKahalalide FSHC1SHC1KLK7KLK7MGAMGAUBR5UBR5GSK3AGSK3AMECOMMECOMCTNNB1CTNNB1IdarubicinIdarubicinKRASKRASPRKG2PRKG2SMARCA4SMARCA4TWF1TWF1MRE11MRE11FGRFGRGLG1GLG1RGL2RGL2PTCH1PTCH1MAP2K7MAP2K7PPP1R3APPP1R3ASTAT6STAT6RB1RB1TNNTNNGRIN2BGRIN2BKinetin ribosideKinetin ribosideZMYM2ZMYM2LMNB1LMNB1MARK4MARK4LASP1LASP1PIP4K2BPIP4K2BFGFR1FGFR1TOX3TOX3CYFIP1CYFIP1STK11STK11ARHGEF7ARHGEF7CYP2B6CYP2B6MERTKMERTKPTK6PTK6WNK2WNK2SUZ12SUZ12DEKDEKGRK2GRK2MAPK10MAPK10TriptolideTriptolideSERPINA2SERPINA2CREBBPCREBBPATMATMTMEM74TMEM74BRCA1BRCA1BRCA2BRCA2BRAFBRAFTANKTANKPTENPTENALPK1ALPK1OlaparibOlaparibABCA3ABCA3TPM4TPM4FANCIFANCISIK2SIK2TSHRTSHRURB2URB2NLRP3NLRP3CDKN2ACDKN2AGRK4GRK4TNIKTNIKPAPPAPAPPACDH2CDH2NFKB1NFKB1TRIM33TRIM33KMT2AKMT2AGSK3BGSK3BIL1RNIL1RNPKN2PKN2PHKG1PHKG1TamatinibTamatinibSTAT3STAT3DYRK1ADYRK1AGTSE1GTSE1PKDCCPKDCCTP53TP53RAP1GDS1RAP1GDS1ERN1ERN1CIITACIITAFGFR3FGFR3ACVRL1ACVRL1HUNKHUNKBMS-754807BMS-754807MMP2MMP2CXCR4CXCR4WDHD1WDHD1WNK1WNK1FANCAFANCAGLI1GLI1ZNF423ZNF423BatimastatBatimastatKPNA5KPNA5MIEN1MIEN1NOTCH1NOTCH1EP300EP300OBSCNOBSCNORMDL3ORMDL3NYNRINNYNRINIL6STIL6STKALRNKALRNCSF3CSF3ATP13A5ATP13A5PDPK1PDPK1ZNF331ZNF331TAF1LTAF1LELAVL1ELAVL1SB225002SB225002PXDNPXDNAXIN2AXIN2EGFREGFRFGFR4FGFR4LRP1BLRP1BSTAG3STAG3nutlin 3nutlin 3MAP3K7MAP3K7

Gene-drug targets distribution

Gene Structure: PDB

Models in MAP3K7

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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