MAP3K7
Summary: The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| mitogen-activated protein kinase kinase kinase 7 | MIM:602614 | Ensembl:ENSG00000135341 | HGNC:HGNC:6859 | PA30603 | 6q15 |
GO terms in MAP3K7
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0000287 | magnesium ion binding |
| MF | IDA | GO:0004672 | protein kinase activity |
| MF | EXP | GO:0004674 | protein serine/threonine kinase activity |
| MF | TAS | GO:0004674 | protein serine/threonine kinase activity |
| MF | EXP | GO:0004709 | MAP kinase kinase kinase activity |
| MF | IBA | GO:0004709 | MAP kinase kinase kinase activity |
| MF | IDA | GO:0004709 | MAP kinase kinase kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IPI | GO:0030971 | receptor tyrosine kinase binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IDA | GO:0097110 | scaffold protein binding |
| BP | IBA | GO:0000186 | activation of MAPKK activity |
| BP | IDA | GO:0000186 | activation of MAPKK activity |
| BP | IDA | GO:0000187 | activation of MAPK activity |
| BP | TAS | GO:0000187 | activation of MAPK activity |
| BP | TAS | GO:0002223 | stimulatory C-type lectin receptor signaling pathway |
| BP | IMP | GO:0002726 | positive regulation of T cell cytokine production |
| BP | TAS | GO:0002755 | MyD88-dependent toll-like receptor signaling pathway |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | TAS | GO:0007179 | transforming growth factor beta receptor signaling pathway |
| BP | TAS | GO:0007223 | Wnt signaling pathway, calcium modulating pathway |
| BP | TAS | GO:0007249 | I-kappaB kinase/NF-kappaB signaling |
| BP | IMP | GO:0007250 | activation of NF-kappaB-inducing kinase activity |
| BP | IDA | GO:0007252 | I-kappaB phosphorylation |
| BP | IDA | GO:0007254 | JNK cascade |
| BP | TAS | GO:0007254 | JNK cascade |
| BP | IEA | GO:0016032 | viral process |
| BP | ISS | GO:0016239 | positive regulation of macroautophagy |
| BP | TAS | GO:0016579 | protein deubiquitination |
| BP | IMP | GO:0032743 | positive regulation of interleukin-2 production |
| BP | TAS | GO:0038095 | Fc-epsilon receptor signaling pathway |
| BP | IMP | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling |
| BP | ISS | GO:0043276 | anoikis |
| BP | IDA | GO:0043507 | positive regulation of JUN kinase activity |
| BP | IMP | GO:0043507 | positive regulation of JUN kinase activity |
| BP | IDA | GO:0043966 | histone H3 acetylation |
| BP | NAS | GO:0050852 | T cell receptor signaling pathway |
| BP | TAS | GO:0050852 | T cell receptor signaling pathway |
| BP | TAS | GO:0051092 | positive regulation of NF-kappaB transcription factor activity |
| BP | IDA | GO:0051403 | stress-activated MAPK cascade |
| BP | TAS | GO:0070423 | nucleotide-binding oligomerization domain containing signaling pathway |
| BP | TAS | GO:0070498 | interleukin-1-mediated signaling pathway |
| CC | HDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005671 | Ada2/Gcn5/Ada3 transcription activator complex |
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0005886 | plasma membrane |
| CC | IPI | GO:0008385 | IkappaB kinase complex |
| CC | TAS | GO:0010008 | endosome membrane |
Gene expression in normal tissue: MAP3K7
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MAP3K7
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | alkpathway | alk in cardiac myocytes |
| biocarta | faspathway | fas signaling pathway (cd95) |
| biocarta | il1rpathway | signal transduction through il1r |
| biocarta | mapkpathway | mapkinase signaling pathway |
| biocarta | nfkbpathway | nf-kb signaling pathway |
| biocarta | nthipathway | nfkb activation by nontypeable hemophilus influenzae |
| biocarta | par1pathway | thrombin signaling and protease-activated receptors |
| biocarta | tgfbpathway | tgf beta signaling pathway |
| biocarta | tollpathway | toll-like receptor pathway |
| biocarta | wntpathway | wnt signaling pathway |
| reactome | R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) |
| reactome | R-HSA-1169091 | Activation of NF-kappaB in B cells |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade |
| reactome | R-HSA-166058 | MyD88:Mal cascade initiated on plasma membrane |
| reactome | R-HSA-166166 | MyD88-independent TLR4 cascade |
| reactome | R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade |
| reactome | R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade |
| reactome | R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade |
| reactome | R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade |
| reactome | R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade |
| reactome | R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade |
| reactome | R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168638 | NOD1/2 Signaling Pathway |
| reactome | R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways |
| reactome | R-HSA-168898 | Toll-Like Receptors Cascades |
| reactome | R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade |
| reactome | R-HSA-195721 | Signaling by WNT |
| reactome | R-HSA-202403 | TCR signaling |
| reactome | R-HSA-202424 | Downstream TCR signaling |
| reactome | R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling |
| reactome | R-HSA-2871837 | FCERI mediated NF-kB activation |
| reactome | R-HSA-3858494 | Beta-catenin independent WNT signaling |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-4086398 | Ca2+ pathway |
| reactome | R-HSA-445989 | TAK1 activates NFkB by phosphorylation and activation of IKKs complex |
| reactome | R-HSA-446652 | Interleukin-1 family signaling |
| reactome | R-HSA-448424 | Interleukin-17 signaling |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-450294 | MAP kinase activation |
| reactome | R-HSA-450302 | activated TAK1 mediates p38 MAPK activation |
| reactome | R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 |
| reactome | R-HSA-5357956 | TNFR1-induced NFkappaB signaling pathway |
| reactome | R-HSA-5607764 | CLEC7A (Dectin-1) signaling |
| reactome | R-HSA-5621481 | C-type lectin receptors (CLRs) |
| reactome | R-HSA-5688426 | Deubiquitination |
| reactome | R-HSA-5689880 | Ub-specific processing proteases |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-73887 | Death Receptor Signalling |
| reactome | R-HSA-75893 | TNF signaling |
| reactome | R-HSA-9014325 | TICAM1,TRAF6-dependent induction of TAK1 complex |
| reactome | R-HSA-9020702 | Interleukin-1 signaling |
| reactome | R-HSA-937042 | IRAK2 mediated activation of TAK1 complex |
| reactome | R-HSA-937061 | TRIF(TICAM1)-mediated TLR4 signaling |
| reactome | R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex |
| reactome | R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
| reactome | R-HSA-975155 | MyD88 dependent cascade initiated on endosome |
| reactome | R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation |
| reactome | R-HSA-975871 | MyD88 cascade initiated on plasma membrane |
| reactome | R-HSA-983705 | Signaling by the B Cell Receptor (BCR) |
| wikipathways | WP1449 | Regulation of toll-like receptor signaling pathway |
| wikipathways | WP195 | IL-1 signaling pathway |
| wikipathways | WP1993 | Angiogenesis overview |
| wikipathways | WP2018 | RANKL-RANK (Receptor activator of NFKB (ligand)) Signaling Pathway |
| wikipathways | WP2036 | TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway |
| wikipathways | WP2112 | IL17 signaling pathway |
| wikipathways | WP23 | B Cell Receptor Signaling Pathway |
| wikipathways | WP231 | TNF alpha Signaling Pathway |
| wikipathways | WP262 | EBV LMP1 signaling |
| wikipathways | WP2637 | Structural Pathway of Interleukin 1 (IL-1) |
| wikipathways | WP2795 | Cardiac Hypertrophic Response |
| wikipathways | WP288 | NLR Proteins |
| wikipathways | WP314 | Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation |
| wikipathways | WP363 | Wnt Signaling Pathway |
| wikipathways | WP364 | IL-6 signaling pathway |
| wikipathways | WP366 | TGF-beta Signaling Pathway |
| wikipathways | WP382 | MAPK Signaling Pathway |
| wikipathways | WP3863 | T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection |
| wikipathways | WP3865 | RIG-I-like Receptor Signaling |
| wikipathways | WP3915 | Angiopoietin Like Protein 8 Regulatory Pathway |
| wikipathways | WP399 | Wnt Signaling Pathway and Pluripotency |
| wikipathways | WP400 | p38 MAPK Signaling Pathway |
| wikipathways | WP428 | Wnt Signaling Pathway |
| wikipathways | WP481 | Insulin Signaling |
| wikipathways | WP69 | T-Cell antigen Receptor (TCR) Signaling Pathway |
| wikipathways | WP710 | DNA Damage Response (only ATM dependent) |
| wikipathways | WP75 | Toll-like Receptor Signaling Pathway |
| netpath | Pathway_BCR | BCR |
| netpath | Pathway_IL1 | IL1 |
| netpath | Pathway_IL6 | IL6 |
| netpath | Pathway_RANKL | RANKL |
| netpath | Pathway_TGF_beta_Receptor | TGF_beta_Receptor |
| netpath | Pathway_TNFalpha | TNFalpha |
| netpath | Pathway_Wnt | Wnt |
| pid | bcr_5pathway | BCR signaling pathway |
| pid | bmppathway | BMP receptor signaling |
| pid | cmyb_pathway | C-MYB transcription factor network |
| pid | ephrinbrevpathway | Ephrin B reverse signaling |
| pid | il1pathway | IL1-mediated signaling events |
| pid | p38_mkk3_6pathway | p38 MAPK signaling pathway |
| pid | ps1pathway | Presenilin action in Notch and Wnt signaling |
| pid | tcrjnkpathway | JNK signaling in the CD4+ TCR pathway |
| pid | tgfbrpathway | TGF-beta receptor signaling |
| pid | tnfpathway | TNF receptor signaling pathway |
| pid | wnt_noncanonical_pathway | Noncanonical Wnt signaling pathway |
| pharmgkb | PA165985892 | Tacrolimus/Cyclosporine Pathway, Pharmacodynamics |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04064 | NF-kappa B signaling pathway - Homo sapiens (human) |
| kegg | hsa04140 | Autophagy - animal - Homo sapiens (human) |
| kegg | hsa04152 | AMPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04310 | Wnt signaling pathway - Homo sapiens (human) |
| kegg | hsa04380 | Osteoclast differentiation - Homo sapiens (human) |
| kegg | hsa04520 | Adherens junction - Homo sapiens (human) |
| kegg | hsa04620 | Toll-like receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04621 | NOD-like receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04622 | RIG-I-like receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04657 | IL-17 signaling pathway - Homo sapiens (human) |
| kegg | hsa04660 | T cell receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04668 | TNF signaling pathway - Homo sapiens (human) |
| kegg | hsa05140 | Leishmaniasis - Homo sapiens (human) |
| kegg | hsa05145 | Toxoplasmosis - Homo sapiens (human) |
| kegg | hsa05162 | Measles - Homo sapiens (human) |
| kegg | hsa05168 | Herpes simplex infection - Homo sapiens (human) |
| kegg | hsa05169 | Epstein-Barr virus infection - Homo sapiens (human) |
| kegg | hsa05418 | Fluid shear stress and atherosclerosis - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD23 | Gossypol | 3 |
| iGMDRD524 | ISX-9 | 1 |
| iGMDRD444 | Tivantinib | 3 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD730 | Kahalalide F | 3 |
| iGMDRD74 | Idarubicin | 3 |
| iGMDRD61 | Kinetin riboside | 3 |
| iGMDRD105 | Triptolide | 3 |
| iGMDRD532 | Olaparib | 3 |
| iGMDRD424 | Tamatinib | 4 |
| iGMDRD546 | BMS-754807 | 1 |
| iGMDRD294 | Batimastat | 2 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD512 | nutlin 3 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MAP3K7
CLASSFICATION
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