MAP3K7 Summary: The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].
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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
GO terms in MAP3K7
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Term Type
Evidence Type
GO Term ID
GO Des.
MF IEA GO:0000287 magnesium ion binding MF IDA GO:0004672 protein kinase activity MF EXP GO:0004674 protein serine/threonine kinase activity MF TAS GO:0004674 protein serine/threonine kinase activity MF EXP GO:0004709 MAP kinase kinase kinase activity MF IBA GO:0004709 MAP kinase kinase kinase activity
Gene expression in normal tissue: MAP3K7
Select Project:
Transcriptome or Gene expression: PRJEB2445
Transcriptome or Gene expression: PRJEB4337
Transcriptome or Gene expression: PRJNA270632
Transcriptome or Gene expression: PRJNA280600
16 tissues mixture adipose adrenal brain breast colon heart kidney liver lung lymph node ovary prostate skeletal muscle testes thyroid white blood cells Export visualization to SVG
Gene-model tissue-cancer distribution: Bubble Plot undefine tissue: undefine
cancer: undefined
model num: 0 undefined tissue: undefined
cancer: PANCAN
model num: 28 BOWE tissue: BOWE
cancer: BOWEL
model num: 0 BOWEL tissue: BOWEL
cancer: undefined
model num: 13
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Gene-drug pathway distribution undefined 10 Leukocyte transendothelial migration 1 IGFR signaling 1 RTK signaling 1 Biosynthesis of secondary metabolites 1 Genome integrity 1
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Pathways in MAP3K7
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Database
Pathway ID
Pathway Des.
biocarta alkpathway alk in cardiac myocytes biocarta faspathway fas signaling pathway (cd95) biocarta il1rpathway signal transduction through il1r biocarta mapkpathway mapkinase signaling pathway biocarta nfkbpathway nf-kb signaling pathway biocarta nthipathway nfkb activation by nontypeable hemophilus influenzae
Gene-Drug: Aster Plot
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Gene in drug-gene network: Network Plot KCNH2 KCNH2 NEK1 NEK1 PDCD1 PDCD1 HDAC2 HDAC2 PHIP PHIP TPH1 TPH1 CTNNA2 CTNNA2 FOXP1 FOXP1 PAX3 PAX3 LRGUK LRGUK HOXD13 HOXD13 PIK3CA PIK3CA LRRK2 LRRK2 RORA RORA PEAK1 PEAK1 WAS WAS GRIA3 GRIA3 Isoevodiamine Isoevodiamine LRRC7 LRRC7 TENM1 TENM1 PCDH15 PCDH15 MINK1 MINK1 AMER1 AMER1 CNTN5 CNTN5 EPHA6 EPHA6 TRAF6 TRAF6 PRAME PRAME DST DST HRAS HRAS Gossypol Gossypol MAP2K4 MAP2K4 ISX-9 ISX-9 PIK3R1 PIK3R1 Tivantinib Tivantinib MSH6 MSH6 LRP2 LRP2 COL14A1 COL14A1 BRIP1 BRIP1 SIK3 SIK3 CACNB2 CACNB2 ZFP69B ZFP69B MAP4K2 MAP4K2 SOS1 SOS1 CNTRL CNTRL ALPK2 ALPK2 GRK7 GRK7 JAG1 JAG1 LY 2183240 LY 2183240 MSH3 MSH3 MYC MYC DHFR DHFR PROC PROC Kahalalide F Kahalalide F SHC1 SHC1 KLK7 KLK7 MGA MGA UBR5 UBR5 GSK3A GSK3A MECOM MECOM CTNNB1 CTNNB1 Idarubicin Idarubicin KRAS KRAS PRKG2 PRKG2 SMARCA4 SMARCA4 TWF1 TWF1 MRE11 MRE11 FGR FGR GLG1 GLG1 RGL2 RGL2 PTCH1 PTCH1 MAP2K7 MAP2K7 PPP1R3A PPP1R3A STAT6 STAT6 RB1 RB1 TNN TNN GRIN2B GRIN2B Kinetin riboside Kinetin riboside ZMYM2 ZMYM2 LMNB1 LMNB1 MARK4 MARK4 LASP1 LASP1 PIP4K2B PIP4K2B FGFR1 FGFR1 TOX3 TOX3 CYFIP1 CYFIP1 STK11 STK11 ARHGEF7 ARHGEF7 CYP2B6 CYP2B6 MERTK MERTK PTK6 PTK6 WNK2 WNK2 SUZ12 SUZ12 DEK DEK GRK2 GRK2 MAPK10 MAPK10 Triptolide Triptolide SERPINA2 SERPINA2 CREBBP CREBBP ATM ATM TMEM74 TMEM74 BRCA1 BRCA1 BRCA2 BRCA2 BRAF BRAF TANK TANK PTEN PTEN ALPK1 ALPK1 Olaparib Olaparib ABCA3 ABCA3 TPM4 TPM4 FANCI FANCI SIK2 SIK2 TSHR TSHR URB2 URB2 NLRP3 NLRP3 CDKN2A CDKN2A GRK4 GRK4 TNIK TNIK PAPPA PAPPA CDH2 CDH2 NFKB1 NFKB1 TRIM33 TRIM33 KMT2A KMT2A GSK3B GSK3B IL1RN IL1RN PKN2 PKN2 PHKG1 PHKG1 Tamatinib Tamatinib STAT3 STAT3 DYRK1A DYRK1A GTSE1 GTSE1 PKDCC PKDCC TP53 TP53 RAP1GDS1 RAP1GDS1 ERN1 ERN1 CIITA CIITA FGFR3 FGFR3 ACVRL1 ACVRL1 HUNK HUNK BMS-754807 BMS-754807 MMP2 MMP2 CXCR4 CXCR4 WDHD1 WDHD1 WNK1 WNK1 FANCA FANCA GLI1 GLI1 ZNF423 ZNF423 Batimastat Batimastat KPNA5 KPNA5 MIEN1 MIEN1 NOTCH1 NOTCH1 EP300 EP300 OBSCN OBSCN ORMDL3 ORMDL3 NYNRIN NYNRIN IL6ST IL6ST KALRN KALRN CSF3 CSF3 ATP13A5 ATP13A5 PDPK1 PDPK1 ZNF331 ZNF331 TAF1L TAF1L ELAVL1 ELAVL1 SB225002 SB225002 PXDN PXDN AXIN2 AXIN2 EGFR EGFR FGFR4 FGFR4 LRP1B LRP1B STAG3 STAG3 nutlin 3 nutlin 3 MAP3K7 MAP3K7
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Gene-drug targets distribution
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Gene Structure: PDB