HNRNPA2B1
Summary: This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. This gene has been described to generate two alternatively spliced transcript variants which encode different isoforms. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:600124 Ensembl IDEnsembl:ENSG00000122566 HGNC IDHGNC:HGNC:5033 PHARMGKB IDPA162391140 Map Location7p15.2 | |||||
Gene Categories:
RNA DIRECTED DNA POLYMERASEGO terms in HNRNPA2B1
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | HDA | GO:0003723 | RNA binding |
| MF | IBA | GO:0003723 | RNA binding |
| MF | IDA | GO:0003723 | RNA binding |
| MF | IBA | GO:0003729 | mRNA binding |
| MF | IBA | GO:0003730 | mRNA 3'-UTR binding |
| MF | IDA | GO:0003730 | mRNA 3'-UTR binding |
Gene expression in normal tissue: HNRNPA2B1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in HNRNPA2B1
Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP4100 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation |
| wikipathways | WP411 | mRNA Processing |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-447115 | Interleukin-12 family signaling |
| reactome | R-HSA-449147 | Signaling by Interleukins |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in HNRNPA2B1
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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