HNRNPA2B1
Summary: This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. This gene has been described to generate two alternatively spliced transcript variants which encode different isoforms. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| heterogeneous nuclear ribonucleoprotein A2/B1 | MIM:600124 | Ensembl:ENSG00000122566 | HGNC:HGNC:5033 | PA162391140 | 7p15.2 |
Gene Categories:
RNA DIRECTED DNA POLYMERASEGO terms in HNRNPA2B1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | HDA | GO:0003723 | RNA binding |
| MF | IBA | GO:0003723 | RNA binding |
| MF | IDA | GO:0003723 | RNA binding |
| MF | IBA | GO:0003729 | mRNA binding |
| MF | IBA | GO:0003730 | mRNA 3'-UTR binding |
| MF | IDA | GO:0003730 | mRNA 3'-UTR binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0035198 | miRNA binding |
| MF | IDA | GO:0043047 | single-stranded telomeric DNA binding |
| MF | IEA | GO:0097157 | pre-mRNA intronic binding |
| MF | ISS | GO:0098505 | G-rich strand telomeric DNA binding |
| MF | IDA | GO:1990247 | N6-methyladenosine-containing RNA binding |
| BP | IEA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IBA | GO:0000398 | mRNA splicing, via spliceosome |
| BP | IC | GO:0000398 | mRNA splicing, via spliceosome |
| BP | IMP | GO:0000398 | mRNA splicing, via spliceosome |
| BP | TAS | GO:0000398 | mRNA splicing, via spliceosome |
| BP | IDA | GO:0006397 | mRNA processing |
| BP | IDA | GO:0006406 | mRNA export from nucleus |
| BP | TAS | GO:0016070 | RNA metabolic process |
| BP | IDA | GO:0031053 | primary miRNA processing |
| BP | TAS | GO:0035722 | interleukin-12-mediated signaling pathway |
| BP | ISS | GO:0044806 | G-quadruplex DNA unwinding |
| BP | IEA | GO:0048025 | negative regulation of mRNA splicing, via spliceosome |
| BP | IDA | GO:0050658 | RNA transport |
| BP | IBA | GO:0051252 | regulation of RNA metabolic process |
| BP | ISS | GO:1904358 | positive regulation of telomere maintenance via telomere lengthening |
| BP | ISS | GO:1905663 | positive regulation of telomerase RNA reverse transcriptase activity |
| BP | IDA | GO:1990428 | miRNA transport |
| CC | ISS | GO:0000781 | chromosome, telomeric region |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005681 | spliceosomal complex |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | ISS | GO:0015030 | Cajal body |
| CC | HDA | GO:0016020 | membrane |
| CC | ISS | GO:0016363 | nuclear matrix |
| CC | IDA | GO:0070062 | extracellular exosome |
| CC | TAS | GO:0070062 | extracellular exosome |
| CC | IDA | GO:0071013 | catalytic step 2 spliceosome |
| CC | IDA | GO:1990904 | ribonucleoprotein complex |
Gene expression in normal tissue: HNRNPA2B1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in HNRNPA2B1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP4100 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation |
| wikipathways | WP411 | mRNA Processing |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-447115 | Interleukin-12 family signaling |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-72163 | mRNA Splicing - Major Pathway |
| reactome | R-HSA-72172 | mRNA Splicing |
| reactome | R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA |
| reactome | R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation |
| reactome | R-HSA-8953854 | Metabolism of RNA |
| reactome | R-HSA-9020591 | Interleukin-12 signaling |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD154 | NSC23766 | 6 |
| iGMDRD375 | GW-405833 | 3 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD177 | Teniposide | 1 |
| iGMDRD297 | Austocystin D | 2 |
| iGMDRD314 | Tanespimycin | 7 |
| iGMDRD405 | PIK-75 | 1 |
| iGMDRD652 | UNC0638 | 3 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD126 | Tipifarnib | 1 |
| iGMDRD451 | Serdemetan | 3 |
| iGMDRD356 | PNU-74654 | 1 |
| iGMDRD60 | Quinoclamine | 7 |
| iGMDRD300 | Tozasertib | 3 |
| iGMDRD366 | PI-103 | 3 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD780 | PP-30 | 2 |
| iGMDRD506 | Fedratinib | 7 |
| iGMDRD74 | Idarubicin | 3 |
| iGMDRD872 | BRD7137 | 3 |
| iGMDRD871 | BRD6368 | 5 |
| iGMDRD187 | BRD9876 | 2 |
| iGMDRD294 | Batimastat | 3 |
| iGMDRD318 | PAC-1 | 3 |
| iGMDRD801 | 2,4-dideoxy-DC-45-A2 | 1 |
| iGMDRD434 | BMS-536924 | 5 |
| iGMDRD171 | Pemetrexed | 1 |
| iGMDRD802 | 4-methylfasudil | 3 |
| iGMDRD158 | NSC141540 | 4 |
| iGMDRD271 | Brefeldin A | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in HNRNPA2B1
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