HNRNPA2B1


Summary: This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. This gene has been described to generate two alternatively spliced transcript variants which encode different isoforms. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
heterogeneous nuclear ribonucleoprotein A2/B1MIM:600124Ensembl:ENSG00000122566HGNC:HGNC:5033PA1623911407p15.2

GO terms in HNRNPA2B1


Term TypeEvidence TypeGO Term IDGO Des.
MFHDAGO:0003723RNA binding
MFIBAGO:0003723RNA binding
MFIDAGO:0003723RNA binding
MFIBAGO:0003729mRNA binding
MFIBAGO:0003730mRNA 3'-UTR binding
MFIDAGO:0003730mRNA 3'-UTR binding
MFIPIGO:0005515protein binding
MFIDAGO:0035198miRNA binding
MFIDAGO:0043047single-stranded telomeric DNA binding
MFIEAGO:0097157pre-mRNA intronic binding
MFISSGO:0098505G-rich strand telomeric DNA binding
MFIDAGO:1990247N6-methyladenosine-containing RNA binding
BPIEAGO:0000122negative regulation of transcription by RNA polymerase II
BPIBAGO:0000398mRNA splicing, via spliceosome
BPICGO:0000398mRNA splicing, via spliceosome
BPIMPGO:0000398mRNA splicing, via spliceosome
BPTASGO:0000398mRNA splicing, via spliceosome
BPIDAGO:0006397mRNA processing
BPIDAGO:0006406mRNA export from nucleus
BPTASGO:0016070RNA metabolic process
BPIDAGO:0031053primary miRNA processing
BPTASGO:0035722interleukin-12-mediated signaling pathway
BPISSGO:0044806G-quadruplex DNA unwinding
BPIEAGO:0048025negative regulation of mRNA splicing, via spliceosome
BPIDAGO:0050658RNA transport
BPIBAGO:0051252regulation of RNA metabolic process
BPISSGO:1904358positive regulation of telomere maintenance via telomere lengthening
BPISSGO:1905663positive regulation of telomerase RNA reverse transcriptase activity
BPIDAGO:1990428miRNA transport
CCISSGO:0000781chromosome, telomeric region
CCIBAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCIDAGO:0005681spliceosomal complex
CCIDAGO:0005737cytoplasm
CCISSGO:0015030Cajal body
CCHDAGO:0016020membrane
CCISSGO:0016363nuclear matrix
CCIDAGO:0070062extracellular exosome
CCTASGO:0070062extracellular exosome
CCIDAGO:0071013catalytic step 2 spliceosome
CCIDAGO:1990904ribonucleoprotein complex

Gene expression in normal tissue: HNRNPA2B1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in HNRNPA2B1


DatabasePathway IDPathway Des.
wikipathwaysWP4100Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
wikipathwaysWP411mRNA Processing
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-168256Immune System
reactomeR-HSA-447115Interleukin-12 family signaling
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-72163mRNA Splicing - Major Pathway
reactomeR-HSA-72172mRNA Splicing
reactomeR-HSA-72203Processing of Capped Intron-Containing Pre-mRNA
reactomeR-HSA-8950505Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
reactomeR-HSA-8953854Metabolism of RNA
reactomeR-HSA-9020591Interleukin-12 signaling

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD154NSC237666
iGMDRD375GW-4058333
iGMDRD280CYTOCHALASIN B3
iGMDRD177Teniposide1
iGMDRD297Austocystin D2
iGMDRD314Tanespimycin7
iGMDRD405PIK-751
iGMDRD652UNC06383
iGMDRD512nutlin 33
iGMDRD126Tipifarnib1
iGMDRD451Serdemetan3
iGMDRD356PNU-746541
iGMDRD60Quinoclamine7
iGMDRD300Tozasertib3
iGMDRD366PI-1033
iGMDRD562Navitoclax3
iGMDRD780PP-302
iGMDRD506Fedratinib7
iGMDRD74Idarubicin3
iGMDRD872BRD71373
iGMDRD871BRD63685
iGMDRD187BRD98762
iGMDRD294Batimastat3
iGMDRD318PAC-13
iGMDRD8012,4-dideoxy-DC-45-A21
iGMDRD434BMS-5369245
iGMDRD171Pemetrexed1
iGMDRD8024-methylfasudil3
iGMDRD158NSC1415404
iGMDRD271Brefeldin A3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in HNRNPA2B1

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