RHOA
Summary: This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ras homolog family member A | MIM:165390 | Ensembl:ENSG00000067560 | HGNC:HGNC:667 | PA134865095 | 3p21.31 |
GO terms in RHOA
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0001666 | response to hypoxia |
| BP | IEA | GO:0001998 | angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure |
| BP | IEA | GO:0002363 | alpha-beta T cell lineage commitment |
| BP | IEA | GO:0003100 | regulation of systemic arterial blood pressure by endothelin |
| BP | IEA | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | IBA | GO:0007015 | actin filament organization |
| BP | IEA | GO:0007160 | cell-matrix adhesion |
| BP | IBA | GO:0007163 | establishment or maintenance of cell polarity |
| BP | TAS | GO:0007179 | transforming growth factor beta receptor signaling pathway |
| BP | TAS | GO:0007186 | G-protein coupled receptor signaling pathway |
| BP | IBA | GO:0007266 | Rho protein signal transduction |
| BP | IDA | GO:0007266 | Rho protein signal transduction |
| BP | IMP | GO:0007266 | Rho protein signal transduction |
| BP | TAS | GO:0007266 | Rho protein signal transduction |
| BP | IEA | GO:0007519 | skeletal muscle tissue development |
| BP | IBA | GO:0008360 | regulation of cell shape |
| BP | IEA | GO:0009612 | response to mechanical stimulus |
| BP | IEA | GO:0009749 | response to glucose |
| BP | ISS | GO:0010812 | negative regulation of cell-substrate adhesion |
| BP | IEA | GO:0016032 | viral process |
| BP | IBA | GO:0016477 | cell migration |
| BP | IDA | GO:0016477 | cell migration |
| BP | IMP | GO:0016477 | cell migration |
| BP | TAS | GO:0016579 | protein deubiquitination |
| BP | HEP | GO:0021762 | substantia nigra development |
| BP | IEA | GO:0021795 | cerebral cortex cell migration |
| BP | IEA | GO:0021861 | forebrain radial glial cell differentiation |
| BP | TAS | GO:0030036 | actin cytoskeleton organization |
| BP | IEA | GO:0030307 | positive regulation of cell growth |
| BP | IBA | GO:0030334 | regulation of cell migration |
| BP | IMP | GO:0030334 | regulation of cell migration |
| BP | IEA | GO:0030521 | androgen receptor signaling pathway |
| BP | IEA | GO:0030838 | positive regulation of actin filament polymerization |
| BP | IBA | GO:0030950 | establishment or maintenance of actin cytoskeleton polarity |
| BP | IEA | GO:0031098 | stress-activated protein kinase signaling cascade |
| BP | IMP | GO:0031532 | actin cytoskeleton reorganization |
| BP | IMP | GO:0032467 | positive regulation of cytokinesis |
| BP | IBA | GO:0032956 | regulation of actin cytoskeleton organization |
| BP | IDA | GO:0032956 | regulation of actin cytoskeleton organization |
| BP | IEA | GO:0033144 | negative regulation of intracellular steroid hormone receptor signaling pathway |
| BP | ISS | GO:0033688 | regulation of osteoblast proliferation |
| BP | IMP | GO:0034329 | cell junction assembly |
| BP | IDA | GO:0035385 | Roundabout signaling pathway |
| BP | IDA | GO:0036089 | cleavage furrow formation |
| BP | IMP | GO:0038027 | apolipoprotein A-I-mediated signaling pathway |
| BP | IEA | GO:0042476 | odontogenesis |
| BP | IEP | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling |
| BP | IEA | GO:0043124 | negative regulation of I-kappaB kinase/NF-kappaB signaling |
| BP | IBA | GO:0043149 | stress fiber assembly |
| BP | IMP | GO:0043149 | stress fiber assembly |
| BP | IEA | GO:0043200 | response to amino acid |
| BP | IEA | GO:0043280 | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| BP | IMP | GO:0043297 | apical junction assembly |
| BP | TAS | GO:0043312 | neutrophil degranulation |
| BP | IEA | GO:0043366 | beta selection |
| BP | IEA | GO:0043524 | negative regulation of neuron apoptotic process |
| BP | IEA | GO:0043525 | positive regulation of neuron apoptotic process |
| BP | IGI | GO:0043542 | endothelial cell migration |
| BP | ISS | GO:0043931 | ossification involved in bone maturation |
| BP | ISS | GO:0044319 | wound healing, spreading of cells |
| BP | IMP | GO:0045198 | establishment of epithelial cell apical/basal polarity |
| BP | IEA | GO:0045471 | response to ethanol |
| BP | IMP | GO:0045666 | positive regulation of neuron differentiation |
| BP | IEA | GO:0045727 | positive regulation of translation |
| BP | IMP | GO:0045792 | negative regulation of cell size |
| BP | IEA | GO:0046039 | GTP metabolic process |
| BP | IEA | GO:0046638 | positive regulation of alpha-beta T cell differentiation |
| BP | TAS | GO:0048010 | vascular endothelial growth factor receptor signaling pathway |
| BP | TAS | GO:0048013 | ephrin receptor signaling pathway |
| BP | TAS | GO:0048015 | phosphatidylinositol-mediated signaling |
| BP | IEA | GO:0048812 | neuron projection morphogenesis |
| BP | TAS | GO:0050771 | negative regulation of axonogenesis |
| BP | TAS | GO:0050772 | positive regulation of axonogenesis |
| BP | IEA | GO:0050773 | regulation of dendrite development |
| BP | IMP | GO:0050919 | negative chemotaxis |
| BP | IBA | GO:0051017 | actin filament bundle assembly |
| BP | TAS | GO:0051056 | regulation of small GTPase mediated signal transduction |
| BP | IEA | GO:0051384 | response to glucocorticoid |
| BP | IDA | GO:0051496 | positive regulation of stress fiber assembly |
| BP | IMP | GO:0051496 | positive regulation of stress fiber assembly |
| BP | TAS | GO:0051893 | regulation of focal adhesion assembly |
| BP | IEA | GO:0051924 | regulation of calcium ion transport |
| BP | NAS | GO:0060071 | Wnt signaling pathway, planar cell polarity pathway |
| BP | TAS | GO:0060071 | Wnt signaling pathway, planar cell polarity pathway |
| BP | IDA | GO:0060193 | positive regulation of lipase activity |
| BP | IMP | GO:0060193 | positive regulation of lipase activity |
| BP | ISS | GO:0061383 | trabecula morphogenesis |
| BP | IEA | GO:0070507 | regulation of microtubule cytoskeleton organization |
| BP | IDA | GO:0071222 | cellular response to lipopolysaccharide |
| BP | HEP | GO:0071277 | cellular response to calcium ion |
| BP | IEA | GO:0071803 | positive regulation of podosome assembly |
| BP | IDA | GO:0071902 | positive regulation of protein serine/threonine kinase activity |
| BP | IGI | GO:0090051 | negative regulation of cell migration involved in sprouting angiogenesis |
| BP | IMP | GO:0090307 | mitotic spindle assembly |
| BP | IEA | GO:0090324 | negative regulation of oxidative phosphorylation |
| BP | IGI | GO:0097498 | endothelial tube lumen extension |
| BP | NAS | GO:1901224 | positive regulation of NIK/NF-kappaB signaling |
| BP | ISS | GO:1902766 | skeletal muscle satellite cell migration |
| BP | IEA | GO:1903427 | negative regulation of reactive oxygen species biosynthetic process |
| BP | IMP | GO:1903673 | mitotic cleavage furrow formation |
| BP | IEA | GO:1904695 | positive regulation of vascular smooth muscle contraction |
| BP | IEA | GO:1905244 | regulation of modification of synaptic structure |
| BP | IMP | GO:1990869 | cellular response to chemokine |
| BP | TAS | GO:2000145 | regulation of cell motility |
| BP | IEA | GO:2000177 | regulation of neural precursor cell proliferation |
| BP | IMP | GO:2000406 | positive regulation of T cell migration |
| CC | IEA | GO:0005634 | nucleus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IMP | GO:0005768 | endosome |
| CC | TAS | GO:0005789 | endoplasmic reticulum membrane |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0005856 | cytoskeleton |
| CC | IBA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | HDA | GO:0005925 | focal adhesion |
| CC | IBA | GO:0005938 | cell cortex |
| CC | IDA | GO:0005938 | cell cortex |
| CC | ISS | GO:0030027 | lamellipodium |
| CC | TAS | GO:0030054 | cell junction |
| CC | IEA | GO:0030424 | axon |
| CC | IEA | GO:0030496 | midbody |
| CC | TAS | GO:0030667 | secretory granule membrane |
| CC | IDA | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane |
| CC | IBA | GO:0031410 | cytoplasmic vesicle |
| CC | IDA | GO:0031982 | vesicle |
| CC | IBA | GO:0032153 | cell division site |
| CC | IBA | GO:0032154 | cleavage furrow |
| CC | IDA | GO:0032154 | cleavage furrow |
| CC | IEA | GO:0032587 | ruffle membrane |
| CC | IBA | GO:0043005 | neuron projection |
| CC | IBA | GO:0043197 | dendritic spine |
| CC | IDA | GO:0043197 | dendritic spine |
| CC | IBA | GO:0043231 | intracellular membrane-bounded organelle |
| CC | IDA | GO:0043296 | apical junction complex |
| CC | HDA | GO:0070062 | extracellular exosome |
| CC | IMP | GO:0071944 | cell periphery |
| CC | TAS | GO:0101003 | ficolin-1-rich granule membrane |
| MF | EXP | GO:0003924 | GTPase activity |
| MF | IBA | GO:0003924 | GTPase activity |
| MF | IDA | GO:0003924 | GTPase activity |
| MF | TAS | GO:0003924 | GTPase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0005525 | GTP binding |
| MF | IDA | GO:0005525 | GTP binding |
| MF | IPI | GO:0017022 | myosin binding |
| MF | IEA | GO:0019003 | GDP binding |
| MF | IBA | GO:0019901 | protein kinase binding |
| MF | IEA | GO:0019904 | protein domain specific binding |
| MF | IEA | GO:0051022 | Rho GDP-dissociation inhibitor binding |
Gene expression in normal tissue: RHOA
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RHOA
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | a4b7_pathway | a4b7 Integrin signaling |
| pid | amb2_neutrophils_pathway | amb2 Integrin signaling |
| pid | arf6downstreampathway | Arf6 downstream pathway |
| pid | aurora_b_pathway | Aurora B signaling |
| pid | avb3_integrin_pathway | Integrins in angiogenesis |
| pid | avb3_opn_pathway | Osteopontin-mediated events |
| pid | cxcr4_pathway | CXCR4-mediated signaling events |
| pid | ecadherin_keratinocyte_pathway | E-cadherin signaling in keratinocytes |
| pid | ecadherin_nascentaj_pathway | E-cadherin signaling in the nascent adherens junction |
| pid | ecadherin_stabilization_pathway | Stabilization and expansion of the E-cadherin adherens junction |
| pid | endothelinpathway | Endothelins |
| pid | epha2_fwdpathway | EPHA2 forward signaling |
| pid | epha_fwdpathway | EPHA forward signaling |
| pid | er_nongenomic_pathway | Plasma membrane estrogen receptor signaling |
| pid | fak_pathway | Signaling events mediated by focal adhesion kinase |
| pid | il2_1pathway | IL2-mediated signaling events |
| pid | lis1pathway | Lissencephaly gene (LIS1) in neuronal migration and development |
| pid | lysophospholipid_pathway | LPA receptor mediated events |
| pid | met_pathway | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
| pid | ncadherinpathway | N-cadherin signaling events |
| pid | netrin_pathway | Netrin-mediated signaling events |
| pid | p75ntrpathway | p75(NTR)-mediated signaling |
| pid | pdgfrbpathway | PDGFR-beta signaling pathway |
| pid | pi3kcipathway | Class I PI3K signaling events |
| pid | plk1_pathway | PLK1 signaling events |
| pid | prlsignalingeventspathway | Signaling events mediated by PRL |
| pid | ptp1bpathway | Signaling events mediated by PTP1B |
| pid | ret_pathway | Signaling events regulated by Ret tyrosine kinase |
| pid | rhoa_pathway | RhoA signaling pathway |
| pid | rhoa_reg_pathway | Regulation of RhoA activity |
| pid | s1p_s1p1_pathway | S1P1 pathway |
| pid | s1p_s1p2_pathway | S1P2 pathway |
| pid | s1p_s1p3_pathway | S1P3 pathway |
| pid | s1p_s1p4_pathway | S1P4 pathway |
| pid | s1p_s1p5_pathway | S1P5 pathway |
| pid | shp2_pathway | SHP2 signaling |
| pid | syndecan_2_pathway | Syndecan-2-mediated signaling events |
| pid | syndecan_4_pathway | Syndecan-4-mediated signaling events |
| pid | thrombin_par1_pathway | PAR1-mediated thrombin signaling events |
| pid | thrombin_par4_pathway | PAR4-mediated thrombin signaling events |
| pid | toll_endogenous_pathway | Endogenous TLR signaling |
| pid | trkrpathway | Neurotrophic factor-mediated Trk receptor signaling |
| pid | txa2pathway | Thromboxane A2 receptor signaling |
| pid | vegfr1_2_pathway | Signaling events mediated by VEGFR1 and VEGFR2 |
| pid | wnt_noncanonical_pathway | Noncanonical Wnt signaling pathway |
| pharmgkb | PA154423660 | Bisphosphonate Pathway, Pharmacodynamics |
| netpath | Pathway_Alpha6Beta4Integrin | Alpha6Beta4Integrin |
| netpath | Pathway_EGFR1 | EGFR1 |
| netpath | Pathway_RAGE | RAGE |
| netpath | Pathway_TGF_beta_Receptor | TGF_beta_Receptor |
| netpath | Pathway_Wnt | Wnt |
| kegg | hsa04014 | Ras signaling pathway - Homo sapiens (human) |
| kegg | hsa04015 | Rap1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04022 | cGMP-PKG signaling pathway - Homo sapiens (human) |
| kegg | hsa04024 | cAMP signaling pathway - Homo sapiens (human) |
| kegg | hsa04062 | Chemokine signaling pathway - Homo sapiens (human) |
| kegg | hsa04071 | Sphingolipid signaling pathway - Homo sapiens (human) |
| kegg | hsa04072 | Phospholipase D signaling pathway - Homo sapiens (human) |
| kegg | hsa04144 | Endocytosis - Homo sapiens (human) |
| kegg | hsa04150 | mTOR signaling pathway - Homo sapiens (human) |
| kegg | hsa04270 | Vascular smooth muscle contraction - Homo sapiens (human) |
| kegg | hsa04310 | Wnt signaling pathway - Homo sapiens (human) |
| kegg | hsa04350 | TGF-beta signaling pathway - Homo sapiens (human) |
| kegg | hsa04360 | Axon guidance - Homo sapiens (human) |
| kegg | hsa04510 | Focal adhesion - Homo sapiens (human) |
| kegg | hsa04520 | Adherens junction - Homo sapiens (human) |
| kegg | hsa04530 | Tight junction - Homo sapiens (human) |
| kegg | hsa04611 | Platelet activation - Homo sapiens (human) |
| kegg | hsa04621 | NOD-like receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04625 | C-type lectin receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04660 | T cell receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04670 | Leukocyte transendothelial migration - Homo sapiens (human) |
| kegg | hsa04722 | Neurotrophin signaling pathway - Homo sapiens (human) |
| kegg | hsa04810 | Regulation of actin cytoskeleton - Homo sapiens (human) |
| kegg | hsa04921 | Oxytocin signaling pathway - Homo sapiens (human) |
| kegg | hsa04972 | Pancreatic secretion - Homo sapiens (human) |
| kegg | hsa05100 | Bacterial invasion of epithelial cells - Homo sapiens (human) |
| kegg | hsa05130 | Pathogenic Escherichia coli infection - Homo sapiens (human) |
| kegg | hsa05133 | Pertussis - Homo sapiens (human) |
| kegg | hsa05152 | Tuberculosis - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05203 | Viral carcinogenesis - Homo sapiens (human) |
| kegg | hsa05205 | Proteoglycans in cancer - Homo sapiens (human) |
| kegg | hsa05206 | MicroRNAs in cancer - Homo sapiens (human) |
| kegg | hsa05210 | Colorectal cancer - Homo sapiens (human) |
| kegg | hsa05418 | Fluid shear stress and atherosclerosis - Homo sapiens (human) |
| wikipathways | WP138 | Androgen receptor signaling pathway |
| wikipathways | WP1528 | Physiological and Pathological Hypertrophy of the Heart |
| wikipathways | WP1544 | MicroRNAs in cardiomyocyte hypertrophy |
| wikipathways | WP2034 | Leptin signaling pathway |
| wikipathways | WP2272 | Pathogenic Escherichia coli infection |
| wikipathways | WP2324 | AGE-RAGE pathway |
| wikipathways | WP2355 | Corticotropin-releasing hormone signaling pathway |
| wikipathways | WP2431 | Spinal Cord Injury |
| wikipathways | WP244 | Alpha 6 Beta 4 signaling pathway |
| wikipathways | WP2593 | JAK-STAT |
| wikipathways | WP306 | Focal Adhesion |
| wikipathways | WP35 | G Protein Signaling Pathways |
| wikipathways | WP363 | Wnt Signaling Pathway |
| wikipathways | WP3655 | Hypothetical Craniofacial Development Pathway |
| wikipathways | WP366 | TGF-beta Signaling Pathway |
| wikipathways | WP3680 | Association Between Physico-Chemical Features and Toxicity Associated Pathways |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| wikipathways | WP399 | Wnt Signaling Pathway and Pluripotency |
| wikipathways | WP4136 | Fibrin Complement Receptor 3 Signaling Pathway |
| wikipathways | WP4150 | Wnt Signaling in Kidney Disease |
| wikipathways | WP4180 | Ebola Virus Pathway on Host |
| wikipathways | WP4216 | Chromosomal and microsatellite instability in colorectal cancer |
| wikipathways | WP4217 | Ebola Virus Pathway on Host |
| wikipathways | WP4223 | Ras Signaling |
| wikipathways | WP428 | Wnt Signaling Pathway |
| wikipathways | WP51 | Regulation of Actin Cytoskeleton |
| wikipathways | WP524 | G13 Signaling Pathway |
| wikipathways | WP710 | DNA Damage Response (only ATM dependent) |
| wikipathways | WP722 | Serotonin HTR1 Group and FOS Pathway |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-114604 | GPVI-mediated activation cascade |
| reactome | R-HSA-1227986 | Signaling by ERBB2 |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-166520 | Signaling by NTRKs |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-170834 | Signaling by TGF-beta Receptor Complex |
| reactome | R-HSA-170834 | Signaling by TGF-beta Receptor Complex |
| reactome | R-HSA-187037 | Signaling by NTRK1 (TRKA) |
| reactome | R-HSA-193634 | Axonal growth inhibition (RHOA activation) |
| reactome | R-HSA-193697 | p75NTR regulates axonogenesis |
| reactome | R-HSA-193704 | p75 NTR receptor-mediated signalling |
| reactome | R-HSA-194138 | Signaling by VEGF |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-194840 | Rho GTPase cycle |
| reactome | R-HSA-195258 | RHO GTPase Effectors |
| reactome | R-HSA-195258 | RHO GTPase Effectors |
| reactome | R-HSA-195721 | Signaling by WNT |
| reactome | R-HSA-198203 | PI3K/AKT activation |
| reactome | R-HSA-209563 | Axonal growth stimulation |
| reactome | R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| reactome | R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| reactome | R-HSA-2682334 | EPH-Ephrin signaling |
| reactome | R-HSA-2682334 | EPH-Ephrin signaling |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-373755 | Semaphorin interactions |
| reactome | R-HSA-373755 | Semaphorin interactions |
| reactome | R-HSA-376176 | Signaling by ROBO receptors |
| reactome | R-HSA-3858494 | Beta-catenin independent WNT signaling |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-392451 | G beta:gamma signalling through PI3Kgamma |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-3928662 | EPHB-mediated forward signaling |
| reactome | R-HSA-3928662 | EPHB-mediated forward signaling |
| reactome | R-HSA-3928663 | EPHA-mediated growth cone collapse |
| reactome | R-HSA-3928663 | EPHA-mediated growth cone collapse |
| reactome | R-HSA-397795 | G-protein beta:gamma signalling |
| reactome | R-HSA-400685 | Sema4D in semaphorin signaling |
| reactome | R-HSA-400685 | Sema4D in semaphorin signaling |
| reactome | R-HSA-4086400 | PCP/CE pathway |
| reactome | R-HSA-416482 | G alpha (12/13) signalling events |
| reactome | R-HSA-416550 | Sema4D mediated inhibition of cell attachment and migration |
| reactome | R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse |
| reactome | R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-4420097 | VEGFA-VEGFR2 Pathway |
| reactome | R-HSA-5625740 | RHO GTPases activate PKNs |
| reactome | R-HSA-5625900 | RHO GTPases activate CIT |
| reactome | R-HSA-5625900 | RHO GTPases activate CIT |
| reactome | R-HSA-5625970 | RHO GTPases activate KTN1 |
| reactome | R-HSA-5627117 | RHO GTPases Activate ROCKs |
| reactome | R-HSA-5627117 | RHO GTPases Activate ROCKs |
| reactome | R-HSA-5663220 | RHO GTPases Activate Formins |
| reactome | R-HSA-5666185 | RHO GTPases Activate Rhotekin and Rhophilins |
| reactome | R-HSA-5666185 | RHO GTPases Activate Rhotekin and Rhophilins |
| reactome | R-HSA-5688426 | Deubiquitination |
| reactome | R-HSA-5689896 | Ovarian tumor domain proteases |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-6785631 | ERBB2 Regulates Cell Motility |
| reactome | R-HSA-6798695 | Neutrophil degranulation |
| reactome | R-HSA-73887 | Death Receptor Signalling |
| reactome | R-HSA-76002 | Platelet activation, signaling and aggregation |
| reactome | R-HSA-8848021 | Signaling by PTK6 |
| reactome | R-HSA-8849471 | PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases |
| reactome | R-HSA-8985586 | SLIT2:ROBO1 increases RHOA activity |
| reactome | R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-9006936 | Signaling by TGF-beta family members |
| reactome | R-HSA-9006936 | Signaling by TGF-beta family members |
| biocarta | akap13pathway | rho-selective guanine exchange factor akap13 mediates stress fiber formation |
| biocarta | akapcentrosomepathway | protein kinase a at the centrosome |
| biocarta | cardiacegfpathway | role of egf receptor transactivation by gpcrs in cardiac hypertrophy |
| biocarta | ccr3pathway | ccr3 signaling in eosinophils |
| biocarta | cdc42racpathway | role of pi3k subunit p85 in regulation of actin organization and cell migration |
| biocarta | d4gdipathway | d4gdi signaling pathway |
| biocarta | ecmpathway | erk and pi-3 kinase are necessary for collagen binding in corneal epithelia |
| biocarta | integrinpathway | integrin signaling pathway |
| biocarta | malpathway | role of mal in rho-mediated activation of srf |
| biocarta | par1pathway | thrombin signaling and protease-activated receptors |
| biocarta | raccycdpathway | influence of ras and rho proteins on g1 to s transition |
| biocarta | raspathway | ras signaling pathway |
| biocarta | rhopathway | rho cell motility signaling pathway |
| biocarta | tffpathway | trefoil factors initiate mucosal healing |
| biocarta | ucalpainpathway | ucalpain and friends in cell spread |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD307 | Manumycin A | 1 |
| iGMDRD84 | Lovastatin acid | 2 |
| iGMDRD116 | CD437 | 3 |
| iGMDRD123 | Isoevodiamine | 5 |
| iGMDRD450 | JNJ-26854165 | 1 |
| iGMDRD901 | ELCPK | 3 |
| iGMDRD121 | GMX1778 | 5 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD481 | Dactolisib | 3 |
| iGMDRD414 | MST-312 | 6 |
| iGMDRD300 | Tozasertib | 2 |
| iGMDRD322 | FK 866 | 4 |
| iGMDRD433 | Lexibulin | 2 |
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD12 | Bicalutamide | 1 |
| iGMDRD546 | BMS-754807 | 2 |
| iGMDRD670 | ML 210 | 2 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD483 | SCH-529074 | 4 |
| iGMDRD193 | Fqi1 | 1 |
| iGMDRD61 | Kinetin riboside | 1 |
| iGMDRD679 | Bistramide A | 3 |
| iGMDRD280 | CYTOCHALASIN B | 1 |
| iGMDRD634 | SCHEMBL2608041 | 3 |
| iGMDRD171 | Pemetrexed | 3 |
| iGMDRD870 | BRD63610 | 2 |
| iGMDRD441 | TW 37 | 1 |
| iGMDRD74 | Idarubicin | 3 |
| iGMDRD887 | Compound 23 citrate | 2 |
| iGMDRD100 | Zebularine | 2 |
| iGMDRD398 | Sepantronium | 2 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD506 | Fedratinib | 5 |
| iGMDRD64 | Parbendazole | 2 |
| iGMDRD356 | PNU-74654 | 2 |
| iGMDRD874 | BRD8958 | 1 |
| iGMDRD23 | Gossypol | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RHOA
CLASSFICATION
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