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RHOA

Summary: This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Nameras homolog family member A OMIM IDMIM:165390 Ensembl IDEnsembl:ENSG00000067560 HGNC IDHGNC:HGNC:667 PHARMGKB IDPA134865095 Map Location3p21.31

Gene Categories:

CELL SURFACE KINASE SERINE THREONINE KINASE TUMOR SUPPRESSOR CLINICALLY ACTIONABLE

GO terms in RHOA

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Term Type	Evidence Type	GO Term ID	GO Des.
BP	IEA	GO:0001666	response to hypoxia
BP	IEA	GO:0001998	angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure
BP	IEA	GO:0002363	alpha-beta T cell lineage commitment
BP	IEA	GO:0003100	regulation of systemic arterial blood pressure by endothelin
BP	IEA	GO:0006357	regulation of transcription by RNA polymerase II
BP	IBA	GO:0007015	actin filament organization

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Gene expression in normal tissue: RHOA

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in RHOA

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Database	Pathway ID	Pathway Des.
pid	a4b7_pathway	a4b7 Integrin signaling
pid	amb2_neutrophils_pathway	amb2 Integrin signaling
pid	arf6downstreampathway	Arf6 downstream pathway
pid	aurora_b_pathway	Aurora B signaling
pid	avb3_integrin_pathway	Integrins in angiogenesis
pid	avb3_opn_pathway	Osteopontin-mediated events

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD307	Manumycin A	1
iGMDRD84	Lovastatin acid	2
iGMDRD116	CD437	3
iGMDRD123	Isoevodiamine	5

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RHOA

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.