DLL1
Summary: DLL1 is a human homolog of the Notch Delta ligand and is a member of the delta/serrate/jagged family. It plays a role in mediating cell fate decisions during hematopoiesis. It may play a role in cell-to-cell communication. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| delta like canonical Notch ligand 1 | MIM:606582 | Ensembl:ENSG00000198719 | HGNC:HGNC:2908 | PA27364 | 6q27 |
Gene Categories:
TRANSCRIPTION FACTOR BINDINGGO terms in DLL1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | NAS | GO:0001709 | cell fate determination |
| BP | ISS | GO:0001756 | somitogenesis |
| BP | IEA | GO:0001757 | somite specification |
| BP | ISS | GO:0001947 | heart looping |
| BP | ISS | GO:0002315 | marginal zone B cell differentiation |
| BP | ISS | GO:0003323 | type B pancreatic cell development |
| BP | IMP | GO:0007219 | Notch signaling pathway |
| BP | ISS | GO:0007219 | Notch signaling pathway |
| BP | NAS | GO:0007219 | Notch signaling pathway |
| BP | TAS | GO:0007219 | Notch signaling pathway |
| BP | ISS | GO:0007368 | determination of left/right symmetry |
| BP | IEA | GO:0007386 | compartment pattern specification |
| BP | ISS | GO:0008217 | regulation of blood pressure |
| BP | ISS | GO:0008284 | positive regulation of cell proliferation |
| BP | ISS | GO:0008285 | negative regulation of cell proliferation |
| BP | ISS | GO:0009954 | proximal/distal pattern formation |
| BP | ISS | GO:0014002 | astrocyte development |
| BP | ISS | GO:0014807 | regulation of somitogenesis |
| BP | ISS | GO:0021510 | spinal cord development |
| BP | ISS | GO:0021688 | cerebellar molecular layer formation |
| BP | ISS | GO:0021693 | cerebellar Purkinje cell layer structural organization |
| BP | NAS | GO:0030097 | hemopoiesis |
| BP | TAS | GO:0030154 | cell differentiation |
| BP | TAS | GO:0030155 | regulation of cell adhesion |
| BP | ISS | GO:0030857 | negative regulation of epithelial cell differentiation |
| BP | IMP | GO:0032693 | negative regulation of interleukin-10 production |
| BP | ISS | GO:0034351 | negative regulation of glial cell apoptotic process |
| BP | ISS | GO:0035265 | organ growth |
| BP | ISS | GO:0040008 | regulation of growth |
| BP | ISS | GO:0045596 | negative regulation of cell differentiation |
| BP | ISS | GO:0045605 | negative regulation of epidermal cell differentiation |
| BP | IEA | GO:0045608 | negative regulation of inner ear auditory receptor cell differentiation |
| BP | IEA | GO:0045638 | negative regulation of myeloid cell differentiation |
| BP | ISS | GO:0045662 | negative regulation of myoblast differentiation |
| BP | ISS | GO:0045665 | negative regulation of neuron differentiation |
| BP | ISS | GO:0045747 | positive regulation of Notch signaling pathway |
| BP | ISS | GO:0045807 | positive regulation of endocytosis |
| BP | ISS | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | ISS | GO:0046331 | lateral inhibition |
| BP | ISS | GO:0048630 | skeletal muscle tissue growth |
| BP | ISS | GO:0048631 | regulation of skeletal muscle tissue growth |
| BP | ISS | GO:0048633 | positive regulation of skeletal muscle tissue growth |
| BP | ISS | GO:0048665 | neuron fate specification |
| BP | IEA | GO:0048839 | inner ear development |
| BP | ISS | GO:0050767 | regulation of neurogenesis |
| BP | ISS | GO:0051302 | regulation of cell division |
| BP | ISS | GO:0060041 | retina development in camera-type eye |
| BP | ISS | GO:0060042 | retina morphogenesis in camera-type eye |
| BP | ISS | GO:0060853 | Notch signaling pathway involved in arterial endothelial cell fate commitment |
| BP | IEA | GO:0070986 | left/right axis specification |
| BP | ISS | GO:0072006 | nephron development |
| BP | IEA | GO:0072014 | proximal tubule development |
| BP | IEA | GO:0072070 | loop of Henle development |
| BP | ISS | GO:0072583 | clathrin-dependent endocytosis |
| BP | ISS | GO:0097009 | energy homeostasis |
| BP | ISS | GO:0097102 | endothelial tip cell fate specification |
| BP | IEP | GO:0097150 | neuronal stem cell population maintenance |
| BP | ISS | GO:0097150 | neuronal stem cell population maintenance |
| BP | ISS | GO:0098773 | skin epidermis development |
| BP | ISS | GO:1900746 | regulation of vascular endothelial growth factor signaling pathway |
| BP | ISS | GO:1903672 | positive regulation of sprouting angiogenesis |
| BP | IEA | GO:2000726 | negative regulation of cardiac muscle cell differentiation |
| CC | NAS | GO:0005576 | extracellular region |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | NAS | GO:0005887 | integral component of plasma membrane |
| CC | ISS | GO:0005912 | adherens junction |
| CC | ISS | GO:0016324 | apical plasma membrane |
| CC | IEA | GO:0031410 | cytoplasmic vesicle |
| CC | ISS | GO:0045121 | membrane raft |
| MF | IPI | GO:0005112 | Notch binding |
| MF | IEA | GO:0005509 | calcium ion binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0030957 | Tat protein binding |
| MF | IEA | GO:0097110 | scaffold protein binding |
Gene expression in normal tissue: DLL1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in DLL1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | hespathway | segmentation clock |
| biocarta | notchpathway | proteolysis and signaling pathway of notch |
| reactome | R-HSA-157118 | Signaling by NOTCH |
| reactome | R-HSA-157118 | Signaling by NOTCH |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-1980143 | Signaling by NOTCH1 |
| reactome | R-HSA-1980145 | Signaling by NOTCH2 |
| reactome | R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus |
| reactome | R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer |
| reactome | R-HSA-2644603 | Signaling by NOTCH1 in Cancer |
| reactome | R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants |
| reactome | R-HSA-2660825 | Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant |
| reactome | R-HSA-2660826 | Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant |
| reactome | R-HSA-2691230 | Signaling by NOTCH1 HD Domain Mutants in Cancer |
| reactome | R-HSA-2691232 | Constitutive Signaling by NOTCH1 HD Domain Mutants |
| reactome | R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer |
| reactome | R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants |
| reactome | R-HSA-2979096 | NOTCH2 Activation and Transmission of Signal to the Nucleus |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| reactome | R-HSA-9012852 | Signaling by NOTCH3 |
| reactome | R-HSA-9012852 | Signaling by NOTCH3 |
| reactome | R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus |
| reactome | R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus |
| wikipathways | WP2064 | Neural Crest Differentiation |
| wikipathways | WP268 | Notch Signaling Pathway |
| wikipathways | WP2854 | Gene regulatory network modelling somitogenesis |
| wikipathways | WP2857 | Mesodermal Commitment Pathway |
| wikipathways | WP3413 | NOTCH1 regulation of human endothelial cell calcification |
| wikipathways | WP3845 | Canonical and Non-canonical Notch signaling |
| wikipathways | WP4239 | EMT transition in Colorectal Cancer |
| wikipathways | WP4242 | Notch Signaling Pathway |
| wikipathways | WP61 | Notch Signaling Pathway |
| pid | notch_pathway | Notch signaling pathway |
| pid | ps1pathway | Presenilin action in Notch and Wnt signaling |
| kegg | hsa04330 | Notch signaling pathway - Homo sapiens (human) |
| kegg | hsa04658 | Th1 and Th2 cell differentiation - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05224 | Breast cancer - Homo sapiens (human) |
| netpath | Pathway_Notch | Notch |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD872 | BRD7137 | 4 |
| iGMDRD414 | MST-312 | 2 |
| iGMDRD42 | Vorinostat | 1 |
| iGMDRD246 | NPC26 | 6 |
| iGMDRD415 | LE-135 | 3 |
| iGMDRD481 | Dactolisib | 1 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD105 | Triptolide | 3 |
| iGMDRD351 | GW843682X | 2 |
| iGMDRD314 | Tanespimycin | 3 |
| iGMDRD512 | nutlin 3 | 1 |
| iGMDRD330 | BRD4132 | 1 |
| iGMDRD84 | Lovastatin acid | 3 |
| iGMDRD79 | Gemcitabine | 4 |
| iGMDRD150 | RITA | 2 |
| iGMDRD532 | Olaparib | 3 |
| iGMDRD887 | Compound 23 citrate | 2 |
| iGMDRD74 | Idarubicin | 3 |
| iGMDRD730 | Kahalalide F | 3 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD356 | PNU-74654 | 3 |
| iGMDRD60 | Quinoclamine | 2 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD802 | 4-methylfasudil | 3 |
| iGMDRD52 | Rotenone | 4 |
| iGMDRD441 | TW 37 | 3 |
| iGMDRD171 | Pemetrexed | 3 |
| iGMDRD61 | Kinetin riboside | 4 |
| iGMDRD634 | SCHEMBL2608041 | 1 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD772 | BRD4770 | 3 |
| iGMDRD599 | Salermide | 3 |
| iGMDRD126 | Tipifarnib | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in DLL1
CLASSFICATION
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