FNTA
Summary: Prenyltransferases can attach either a farnesyl group or a geranylgeranyl group in thioether linkage to the cysteine residue of proteins with a C-terminal CAAX box. CAAX geranylgeranyltransferase and CAAX farnesyltransferase are heterodimers that share the same alpha subunit but have different beta subunits. This gene encodes the alpha subunit of these transferases. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 11 and 13. [provided by RefSeq, May 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| farnesyltransferase, CAAX box, alpha | MIM:134635 | Ensembl:ENSG00000168522 | HGNC:HGNC:3782 | PA28199 | 8p11.21 |
Gene Categories:
DRUGGABLE GENOMEGO terms in FNTA
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004660 | protein farnesyltransferase activity |
| MF | IDA | GO:0004660 | protein farnesyltransferase activity |
| MF | IDA | GO:0004660 | protein farnesyltransferase activity |
| MF | IDA | GO:0004661 | protein geranylgeranyltransferase activity |
| MF | IBA | GO:0004662 | CAAX-protein geranylgeranyltransferase activity |
| MF | IEA | GO:0004663 | Rab geranylgeranyltransferase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0008017 | microtubule binding |
| MF | IEA | GO:0030548 | acetylcholine receptor regulator activity |
| MF | IEA | GO:0030971 | receptor tyrosine kinase binding |
| MF | IDA | GO:0043014 | alpha-tubulin binding |
| BP | TAS | GO:0007179 | transforming growth factor beta receptor signaling pathway |
| BP | IBA | GO:0018343 | protein farnesylation |
| BP | IDA | GO:0018343 | protein farnesylation |
| BP | IBA | GO:0018344 | protein geranylgeranylation |
| BP | IDA | GO:0018344 | protein geranylgeranylation |
| BP | IEA | GO:0045213 | neurotransmitter receptor metabolic process |
| BP | IEA | GO:0071340 | skeletal muscle acetylcholine-gated channel clustering |
| BP | IDA | GO:0090044 | positive regulation of tubulin deacetylation |
| BP | IDA | GO:0090045 | positive regulation of deacetylase activity |
| BP | IEA | GO:0099601 | regulation of neurotransmitter receptor activity |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0005875 | microtubule associated complex |
| CC | IEA | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005953 | CAAX-protein geranylgeranyltransferase complex |
| CC | IDA | GO:0005953 | CAAX-protein geranylgeranyltransferase complex |
| CC | IBA | GO:0005965 | protein farnesyltransferase complex |
| CC | IDA | GO:0005965 | protein farnesyltransferase complex |
Gene expression in normal tissue: FNTA
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in FNTA
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-109581 | Apoptosis |
| reactome | R-HSA-111465 | Apoptotic cleavage of cellular proteins |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-2187338 | Visual phototransduction |
| reactome | R-HSA-2514856 | The phototransduction cascade |
| reactome | R-HSA-2514859 | Inactivation, recovery and regulation of the phototransduction cascade |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-418594 | G alpha (i) signalling events |
| reactome | R-HSA-5357801 | Programmed Cell Death |
| reactome | R-HSA-75153 | Apoptotic execution phase |
| netpath | Pathway_TGF_beta_Receptor | TGF_beta_Receptor |
| kegg | hsa00900 | Terpenoid backbone biosynthesis - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD316 | N9-Isopropyl-olomoucine | 3 |
| iGMDRD888 | Compound 44 | 3 |
| iGMDRD237 | ABT-751 | 3 |
| iGMDRD366 | PI-103 | 3 |
| iGMDRD100 | Zebularine | 3 |
| iGMDRD74 | Idarubicin | 3 |
| iGMDRD201 | SKI II | 1 |
| iGMDRD356 | PNU-74654 | 1 |
| iGMDRD82 | Quiflapon | 3 |
| iGMDRD772 | BRD4770 | 3 |
| iGMDRD579 | PF750 | 3 |
| iGMDRD270 | Ciclosporin | 3 |
| iGMDRD52 | Rotenone | 3 |
| iGMDRD213 | SMR000068650 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in FNTA
CLASSFICATION
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