FNTA

Summary: Prenyltransferases can attach either a farnesyl group or a geranylgeranyl group in thioether linkage to the cysteine residue of proteins with a C-terminal CAAX box. CAAX geranylgeranyltransferase and CAAX farnesyltransferase are heterodimers that share the same alpha subunit but have different beta subunits. This gene encodes the alpha subunit of these transferases. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 11 and 13. [provided by RefSeq, May 2010].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namefarnesyltransferase, CAAX box, alpha
OMIM IDMIM:134635
Ensembl IDEnsembl:ENSG00000168522
HGNC IDHGNC:HGNC:3782
PHARMGKB IDPA28199
Map Location8p11.21

Gene Categories:

DRUGGABLE GENOME

GO terms in FNTA


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IBA GO:0004660 protein farnesyltransferase activity
MF IDA GO:0004660 protein farnesyltransferase activity
MF IDA GO:0004660 protein farnesyltransferase activity
MF IDA GO:0004661 protein geranylgeranyltransferase activity
MF IBA GO:0004662 CAAX-protein geranylgeranyltransferase activity
MF IEA GO:0004663 Rab geranylgeranyltransferase activity
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Gene expression in normal tissue: FNTA

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined11Biosynthesis of secondary metabolites1PI3K/MTOR signaling1Th17 cell differentiation1

Pathways in FNTA


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Database
Pathway ID
Pathway Des.
reactome R-HSA-109581 Apoptosis
reactome R-HSA-111465 Apoptotic cleavage of cellular proteins
reactome R-HSA-162582 Signal Transduction
reactome R-HSA-2187338 Visual phototransduction
reactome R-HSA-2514856 The phototransduction cascade
reactome R-HSA-2514859 Inactivation, recovery and regulation of the phototransduction cascade
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD316 N9-Isopropyl-olomoucine 3
iGMDRD888 Compound 44 3
iGMDRD237 ABT-751 3
iGMDRD366 PI-103 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FNTA

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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