PAK5


Summary: The protein encoded by this gene is a member of the PAK family of Ser/Thr protein kinases. PAK family members are known to be effectors of Rac/Cdc42 GTPases, which have been implicated in the regulation of cytoskeletal dynamics, proliferation, and cell survival signaling. This kinase contains a CDC42/Rac1 interactive binding (CRIB) motif, and has been shown to bind CDC42 in the presence of GTP. This kinase is predominantly expressed in brain. It is capable of promoting neurite outgrowth, and thus may play a role in neurite development. This kinase is associated with microtubule networks and induces microtubule stabilization. The subcellular localization of this kinase is tightly regulated during cell cycle progression. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
p21 (RAC1) activated kinase 5MIM:608038Ensembl:ENSG00000101349HGNC:HGNC:15916PA3292220p12.2

GO terms in PAK5


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0004674protein serine/threonine kinase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIBAGO:0048365Rac GTPase binding
BPTASGO:0001558regulation of cell growth
BPTASGO:0006915apoptotic process
BPTASGO:0007010cytoskeleton organization
BPTASGO:0007165signal transduction
BPIBAGO:0007266Rho protein signal transduction
BPIBAGO:0007346regulation of mitotic cell cycle
BPIEAGO:0007612learning
BPIEAGO:0007613memory
BPIEAGO:0007626locomotory behavior
BPTASGO:0008283cell proliferation
BPIBAGO:0016477cell migration
BPTASGO:0016477cell migration
BPIBAGO:0023014signal transduction by protein phosphorylation
BPIBAGO:0030036actin cytoskeleton organization
BPIBAGO:0032147activation of protein kinase activity
BPIBAGO:0043408regulation of MAPK cascade
BPIEAGO:2001237negative regulation of extrinsic apoptotic signaling pathway
CCIDAGO:0005654nucleoplasm
CCIBAGO:0005737cytoplasm
CCIEAGO:0005739mitochondrion

Gene expression in normal tissue: PAK5

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PAK5


DatabasePathway IDPathway Des.
biocartaagrpathwayagrin in postsynaptic differentiation
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-376176Signaling by ROBO receptors
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-428540Activation of RAC1
wikipathwaysWP4205MET in type 1 papillary renal cell carcinoma
wikipathwaysWP4223Ras Signaling
wikipathwaysWP51Regulation of Actin Cytoskeleton
kegghsa04012ErbB signaling pathway - Homo sapiens (human)
kegghsa04014Ras signaling pathway - Homo sapiens (human)
kegghsa04360Axon guidance - Homo sapiens (human)
kegghsa04510Focal adhesion - Homo sapiens (human)
kegghsa04660T cell receptor signaling pathway - Homo sapiens (human)
kegghsa04810Regulation of actin cytoskeleton - Homo sapiens (human)
kegghsa05211Renal cell carcinoma - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD394BX-7951
iGMDRD466Chaetocin2
iGMDRD201SKI II3
iGMDRD107Valdecoxib3
iGMDRD61Kinetin riboside2
iGMDRD427ABT7373
iGMDRD670ML 2103
iGMDRD144NSC953973
iGMDRD781Sirolimus3
iGMDRD494Neopeltolide2
iGMDRD151CHM-11
iGMDRD76Simvastatin3
iGMDRD126Tipifarnib5
iGMDRD772BRD47701
iGMDRD599Salermide2
iGMDRD874BRD89583
iGMDRD23Gossypol3
iGMDRD74Idarubicin2
iGMDRD100Zebularine4
iGMDRD398Sepantronium4
iGMDRD888Compound 442
iGMDRD782DC-45-A22
iGMDRD318PAC-13
iGMDRD441TW 371
iGMDRD613CHEMBL2581482
iGMDRD260FQI-21
iGMDRD211(1S,3R)-RSL33
iGMDRD132(-)-gallocatechin-3-O-gallate3
iGMDRD698Neratinib3
iGMDRD424Tamatinib2
iGMDRD150RITA6
iGMDRD701NVP-AUY9223
iGMDRD84Lovastatin acid3
iGMDRD607Ubistatin B2
iGMDRD512nutlin 32
iGMDRD886Compound 1541A2
iGMDRD322FK 8662
iGMDRD82Quiflapon3
iGMDRD871BRD63683
iGMDRD329Merck603
iGMDRD6AM-5804
iGMDRD289Parthenolide2
iGMDRD481Dactolisib2
iGMDRD121GMX17783

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PAK5

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