PAK5
Summary: The protein encoded by this gene is a member of the PAK family of Ser/Thr protein kinases. PAK family members are known to be effectors of Rac/Cdc42 GTPases, which have been implicated in the regulation of cytoskeletal dynamics, proliferation, and cell survival signaling. This kinase contains a CDC42/Rac1 interactive binding (CRIB) motif, and has been shown to bind CDC42 in the presence of GTP. This kinase is predominantly expressed in brain. It is capable of promoting neurite outgrowth, and thus may play a role in neurite development. This kinase is associated with microtubule networks and induces microtubule stabilization. The subcellular localization of this kinase is tightly regulated during cell cycle progression. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| p21 (RAC1) activated kinase 5 | MIM:608038 | Ensembl:ENSG00000101349 | HGNC:HGNC:15916 | PA32922 | 20p12.2 |
GO terms in PAK5
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IBA | GO:0048365 | Rac GTPase binding |
| BP | TAS | GO:0001558 | regulation of cell growth |
| BP | TAS | GO:0006915 | apoptotic process |
| BP | TAS | GO:0007010 | cytoskeleton organization |
| BP | TAS | GO:0007165 | signal transduction |
| BP | IBA | GO:0007266 | Rho protein signal transduction |
| BP | IBA | GO:0007346 | regulation of mitotic cell cycle |
| BP | IEA | GO:0007612 | learning |
| BP | IEA | GO:0007613 | memory |
| BP | IEA | GO:0007626 | locomotory behavior |
| BP | TAS | GO:0008283 | cell proliferation |
| BP | IBA | GO:0016477 | cell migration |
| BP | TAS | GO:0016477 | cell migration |
| BP | IBA | GO:0023014 | signal transduction by protein phosphorylation |
| BP | IBA | GO:0030036 | actin cytoskeleton organization |
| BP | IBA | GO:0032147 | activation of protein kinase activity |
| BP | IBA | GO:0043408 | regulation of MAPK cascade |
| BP | IEA | GO:2001237 | negative regulation of extrinsic apoptotic signaling pathway |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005739 | mitochondrion |
Gene expression in normal tissue: PAK5
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PAK5
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | agrpathway | agrin in postsynaptic differentiation |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-376176 | Signaling by ROBO receptors |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-428540 | Activation of RAC1 |
| wikipathways | WP4205 | MET in type 1 papillary renal cell carcinoma |
| wikipathways | WP4223 | Ras Signaling |
| wikipathways | WP51 | Regulation of Actin Cytoskeleton |
| kegg | hsa04012 | ErbB signaling pathway - Homo sapiens (human) |
| kegg | hsa04014 | Ras signaling pathway - Homo sapiens (human) |
| kegg | hsa04360 | Axon guidance - Homo sapiens (human) |
| kegg | hsa04510 | Focal adhesion - Homo sapiens (human) |
| kegg | hsa04660 | T cell receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04810 | Regulation of actin cytoskeleton - Homo sapiens (human) |
| kegg | hsa05211 | Renal cell carcinoma - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD394 | BX-795 | 1 |
| iGMDRD466 | Chaetocin | 2 |
| iGMDRD201 | SKI II | 3 |
| iGMDRD107 | Valdecoxib | 3 |
| iGMDRD61 | Kinetin riboside | 2 |
| iGMDRD427 | ABT737 | 3 |
| iGMDRD670 | ML 210 | 3 |
| iGMDRD144 | NSC95397 | 3 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD494 | Neopeltolide | 2 |
| iGMDRD151 | CHM-1 | 1 |
| iGMDRD76 | Simvastatin | 3 |
| iGMDRD126 | Tipifarnib | 5 |
| iGMDRD772 | BRD4770 | 1 |
| iGMDRD599 | Salermide | 2 |
| iGMDRD874 | BRD8958 | 3 |
| iGMDRD23 | Gossypol | 3 |
| iGMDRD74 | Idarubicin | 2 |
| iGMDRD100 | Zebularine | 4 |
| iGMDRD398 | Sepantronium | 4 |
| iGMDRD888 | Compound 44 | 2 |
| iGMDRD782 | DC-45-A2 | 2 |
| iGMDRD318 | PAC-1 | 3 |
| iGMDRD441 | TW 37 | 1 |
| iGMDRD613 | CHEMBL258148 | 2 |
| iGMDRD260 | FQI-2 | 1 |
| iGMDRD211 | (1S,3R)-RSL3 | 3 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 3 |
| iGMDRD698 | Neratinib | 3 |
| iGMDRD424 | Tamatinib | 2 |
| iGMDRD150 | RITA | 6 |
| iGMDRD701 | NVP-AUY922 | 3 |
| iGMDRD84 | Lovastatin acid | 3 |
| iGMDRD607 | Ubistatin B | 2 |
| iGMDRD512 | nutlin 3 | 2 |
| iGMDRD886 | Compound 1541A | 2 |
| iGMDRD322 | FK 866 | 2 |
| iGMDRD82 | Quiflapon | 3 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD6 | AM-580 | 4 |
| iGMDRD289 | Parthenolide | 2 |
| iGMDRD481 | Dactolisib | 2 |
| iGMDRD121 | GMX1778 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PAK5
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