CDKL2
Summary: This gene product is a member of a large family of CDC2-related serine/threonine protein kinases. It accumulates primarily in the cytoplasm, with lower levels in the nucleus. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| cyclin dependent kinase like 2 | MIM:603442 | Ensembl:ENSG00000138769 | HGNC:HGNC:1782 | PA26318 | 4q21.1 |
GO terms in CDKL2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IBA | GO:0006468 | protein phosphorylation |
| BP | IEA | GO:0006468 | protein phosphorylation |
| BP | TAS | GO:0007165 | signal transduction |
| BP | TAS | GO:0007548 | sex differentiation |
| BP | IEA | GO:0051726 | regulation of cell cycle |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IEA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005813 | centrosome |
| MF | TAS | GO:0004672 | protein kinase activity |
| MF | IBA | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity |
| MF | IEA | GO:0005524 | ATP binding |
Gene expression in normal tissue: CDKL2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CDKL2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP4239 | EMT transition in Colorectal Cancer |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD71 | Sparfosic acid | 3 |
| iGMDRD193 | Fqi1 | 5 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD466 | Chaetocin | 2 |
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD151 | CHM-1 | 2 |
| iGMDRD433 | Lexibulin | 5 |
| iGMDRD420 | Leucascandrolide A | 3 |
| iGMDRD1008 | SR-II-138A | 2 |
| iGMDRD670 | ML 210 | 3 |
| iGMDRD779 | PRL-3 Inhibitor I | 2 |
| iGMDRD494 | Neopeltolide | 1 |
| iGMDRD483 | SCH-529074 | 3 |
| iGMDRD188 | Piperlongumine | 4 |
| iGMDRD887 | Compound 23 citrate | 1 |
| iGMDRD74 | Idarubicin | 2 |
| iGMDRD399 | Selumetinib | 3 |
| iGMDRD780 | PP-30 | 3 |
| iGMDRD64 | Parbendazole | 6 |
| iGMDRD356 | PNU-74654 | 1 |
| iGMDRD451 | Serdemetan | 2 |
| iGMDRD138 | PX 12 | 3 |
| iGMDRD260 | FQI-2 | 2 |
| iGMDRD802 | 4-methylfasudil | 2 |
| iGMDRD171 | Pemetrexed | 3 |
| iGMDRD441 | TW 37 | 2 |
| iGMDRD318 | PAC-1 | 2 |
| iGMDRD187 | BRD9876 | 4 |
| iGMDRD341 | Triacsin c | 2 |
| iGMDRD351 | GW843682X | 2 |
| iGMDRD237 | ABT-751 | 4 |
| iGMDRD211 | (1S,3R)-RSL3 | 3 |
| iGMDRD123 | Isoevodiamine | 4 |
| iGMDRD154 | NSC23766 | 1 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 4 |
| iGMDRD945 | ML214 | 2 |
| iGMDRD584 | VER 155008 | 1 |
| iGMDRD405 | PIK-75 | 6 |
| iGMDRD286 | Nsc 632839 | 2 |
| iGMDRD872 | BRD7137 | 2 |
| iGMDRD662 | JQ-1 | 2 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD505 | Pevonedistat | 1 |
| iGMDRD246 | NPC26 | 5 |
| iGMDRD263 | AACOCF3 | 1 |
| iGMDRD552 | AZD-1775 | 1 |
| iGMDRD121 | GMX1778 | 2 |
| iGMDRD202 | Curcumin | 1 |
| iGMDRD271 | Brefeldin A | 2 |
| iGMDRD105 | Triptolide | 3 |
| iGMDRD289 | Parthenolide | 5 |
| iGMDRD434 | BMS-536924 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CDKL2
CLASSFICATION
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