SCYL2
Summary: The protein encoded by this gene associates with clathrin-coated complexes at the plasma membrane and with endocytic coated vesicles. The encoded protein phosphorylates the beta2 subunit of the plasma membrane adapter complex AP2 and interacts with clathrin, showing involvement in clathrin-dependent pathways between the trans-Golgi network and the endosomal system. In addition, this protein has a role in the Wnt signaling pathway by targeting frizzled 5 (Fzd5) for lysosomal degradation. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| SCY1 like pseudokinase 2 | MIM:616365 | Ensembl:ENSG00000136021 | HGNC:HGNC:19286 | PA134887807 | 12q23.1 |
GO terms in SCYL2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IDA | GO:0002092 | positive regulation of receptor internalization |
| BP | IEA | GO:0006468 | protein phosphorylation |
| BP | IDA | GO:0008333 | endosome to lysosome transport |
| BP | IDA | GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| BP | IDA | GO:2000286 | receptor internalization involved in canonical Wnt signaling pathway |
| BP | IDA | GO:2000370 | positive regulation of clathrin-dependent endocytosis |
| CC | IEA | GO:0005794 | Golgi apparatus |
| CC | IEA | GO:0010008 | endosome membrane |
| CC | IEA | GO:0030136 | clathrin-coated vesicle |
| CC | IEA | GO:0048471 | perinuclear region of cytoplasm |
| MF | IEA | GO:0004672 | protein kinase activity |
| MF | IPI | GO:0005102 | signaling receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
Gene expression in normal tissue: SCYL2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SCYL2
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD123 | Isoevodiamine | 5 |
| iGMDRD945 | ML214 | 3 |
| iGMDRD85 | Ursolic acid | 1 |
| iGMDRD698 | Neratinib | 2 |
| iGMDRD57 | Chloropentafluorobenzene | 2 |
| iGMDRD79 | Gemcitabine | 3 |
| iGMDRD84 | Lovastatin acid | 3 |
| iGMDRD263 | AACOCF3 | 1 |
| iGMDRD246 | NPC26 | 3 |
| iGMDRD300 | Tozasertib | 3 |
| iGMDRD886 | Compound 1541A | 2 |
| iGMDRD322 | FK 866 | 5 |
| iGMDRD289 | Parthenolide | 5 |
| iGMDRD202 | Curcumin | 3 |
| iGMDRD121 | GMX1778 | 5 |
| iGMDRD5 | Tyrphostin AG 1478 | 2 |
| iGMDRD466 | Chaetocin | 2 |
| iGMDRD280 | CYTOCHALASIN B | 2 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD61 | Kinetin riboside | 1 |
| iGMDRD151 | CHM-1 | 2 |
| iGMDRD1008 | SR-II-138A | 2 |
| iGMDRD599 | Salermide | 1 |
| iGMDRD60 | Quinoclamine | 2 |
| iGMDRD64 | Parbendazole | 2 |
| iGMDRD451 | Serdemetan | 2 |
| iGMDRD356 | PNU-74654 | 1 |
| iGMDRD74 | Idarubicin | 2 |
| iGMDRD399 | Selumetinib | 2 |
| iGMDRD100 | Zebularine | 4 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD398 | Sepantronium | 2 |
| iGMDRD138 | PX 12 | 4 |
| iGMDRD260 | FQI-2 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SCYL2
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