SCYL2
Summary: The protein encoded by this gene associates with clathrin-coated complexes at the plasma membrane and with endocytic coated vesicles. The encoded protein phosphorylates the beta2 subunit of the plasma membrane adapter complex AP2 and interacts with clathrin, showing involvement in clathrin-dependent pathways between the trans-Golgi network and the endosomal system. In addition, this protein has a role in the Wnt signaling pathway by targeting frizzled 5 (Fzd5) for lysosomal degradation. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2015].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:616365 Ensembl IDEnsembl:ENSG00000136021 HGNC IDHGNC:HGNC:19286 PHARMGKB IDPA134887807 Map Location12q23.1 | |||||
GO terms in SCYL2
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IDA | GO:0002092 | positive regulation of receptor internalization |
| BP | IEA | GO:0006468 | protein phosphorylation |
| BP | IDA | GO:0008333 | endosome to lysosome transport |
| BP | IDA | GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| BP | IDA | GO:2000286 | receptor internalization involved in canonical Wnt signaling pathway |
| BP | IDA | GO:2000370 | positive regulation of clathrin-dependent endocytosis |
Gene expression in normal tissue: SCYL2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SCYL2
Database | Pathway ID | Pathway Des. |
|---|---|---|
| No matching records found | ||
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SCYL2
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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