SMURF1
Summary: This gene encodes a ubiquitin ligase that is specific for receptor-regulated SMAD proteins in the bone morphogenetic protein (BMP) pathway. This protein plays a key roll in the regulation of cell motility, cell signalling, and cell polarity. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Dec 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| SMAD specific E3 ubiquitin protein ligase 1 | MIM:605568 | Ensembl:ENSG00000198742 | HGNC:HGNC:16807 | PA134987175 | 7q22.1 |
GO terms in SMURF1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0004842 | ubiquitin-protein transferase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | TAS | GO:0005543 | phospholipid binding |
| MF | NAS | GO:0048185 | activin binding |
| MF | IBA | GO:0061630 | ubiquitin protein ligase activity |
| MF | IDA | GO:0061630 | ubiquitin protein ligase activity |
| MF | TAS | GO:0061630 | ubiquitin protein ligase activity |
| MF | IPI | GO:0070411 | I-SMAD binding |
| MF | IPI | GO:0070412 | R-SMAD binding |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IGI | GO:0005739 | mitochondrion |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | IEA | GO:0030424 | axon |
| CC | IEA | GO:0043025 | neuronal cell body |
| CC | HDA | GO:0070062 | extracellular exosome |
| BP | IBA | GO:0000209 | protein polyubiquitination |
| BP | IDA | GO:0000209 | protein polyubiquitination |
| BP | IDA | GO:0006511 | ubiquitin-dependent protein catabolic process |
| BP | IDA | GO:0006611 | protein export from nucleus |
| BP | TAS | GO:0007179 | transforming growth factor beta receptor signaling pathway |
| BP | TAS | GO:0007398 | ectoderm development |
| BP | IBA | GO:0016567 | protein ubiquitination |
| BP | IDA | GO:0016567 | protein ubiquitination |
| BP | IDA | GO:0030154 | cell differentiation |
| BP | IEA | GO:0030279 | negative regulation of ossification |
| BP | IDA | GO:0030509 | BMP signaling pathway |
| BP | TAS | GO:0030509 | BMP signaling pathway |
| BP | IDA | GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway |
| BP | IBA | GO:0030514 | negative regulation of BMP signaling pathway |
| BP | IDA | GO:0030514 | negative regulation of BMP signaling pathway |
| BP | TAS | GO:0030514 | negative regulation of BMP signaling pathway |
| BP | IBA | GO:0030579 | ubiquitin-dependent SMAD protein catabolic process |
| BP | IDA | GO:0030579 | ubiquitin-dependent SMAD protein catabolic process |
| BP | IDA | GO:0032801 | receptor catabolic process |
| BP | IDA | GO:0034394 | protein localization to cell surface |
| BP | IBA | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process |
| BP | IDA | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process |
| BP | IBA | GO:0045732 | positive regulation of protein catabolic process |
| BP | TAS | GO:0060071 | Wnt signaling pathway, planar cell polarity pathway |
| BP | IEA | GO:0061734 | parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization |
| BP | IMP | GO:0061736 | engulfment of target by autophagosome |
| BP | IMP | GO:0061753 | substrate localization to autophagosome |
| BP | IMP | GO:0071211 | protein targeting to vacuole involved in autophagy |
| BP | TAS | GO:0072659 | protein localization to plasma membrane |
| BP | IDA | GO:1903861 | positive regulation of dendrite extension |
| BP | IMP | GO:2000060 | positive regulation of ubiquitin-dependent protein catabolic process |
Gene expression in normal tissue: SMURF1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SMURF1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| netpath | Pathway_TGF_beta_Receptor | TGF_beta_Receptor |
| pid | bmppathway | BMP receptor signaling |
| pid | hdac_classi_pathway | Signaling events mediated by HDAC Class I |
| pid | tgfbrpathway | TGF-beta receptor signaling |
| kegg | hsa04120 | Ubiquitin mediated proteolysis - Homo sapiens (human) |
| kegg | hsa04144 | Endocytosis - Homo sapiens (human) |
| kegg | hsa04340 | Hedgehog signaling pathway - Homo sapiens (human) |
| kegg | hsa04350 | TGF-beta signaling pathway - Homo sapiens (human) |
| wikipathways | WP1425 | Bone Morphogenic Protein (BMP) Signalling and Regulation |
| wikipathways | WP2858 | Ectoderm Differentiation |
| wikipathways | WP366 | TGF-beta Signaling Pathway |
| wikipathways | WP4249 | Hedgehog Signaling Pathway |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-170834 | Signaling by TGF-beta Receptor Complex |
| reactome | R-HSA-170834 | Signaling by TGF-beta Receptor Complex |
| reactome | R-HSA-195721 | Signaling by WNT |
| reactome | R-HSA-201451 | Signaling by BMP |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-2173788 | Downregulation of TGF-beta receptor signaling |
| reactome | R-HSA-2173789 | TGF-beta receptor signaling activates SMADs |
| reactome | R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| reactome | R-HSA-3858494 | Beta-catenin independent WNT signaling |
| reactome | R-HSA-4086400 | PCP/CE pathway |
| reactome | R-HSA-4608870 | Asymmetric localization of PCP proteins |
| reactome | R-HSA-5358351 | Signaling by Hedgehog |
| reactome | R-HSA-5358351 | Signaling by Hedgehog |
| reactome | R-HSA-5632684 | Hedgehog 'on' state |
| reactome | R-HSA-5632684 | Hedgehog 'on' state |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8878159 | Transcriptional regulation by RUNX3 |
| reactome | R-HSA-8878166 | Transcriptional regulation by RUNX2 |
| reactome | R-HSA-8878166 | Transcriptional regulation by RUNX2 |
| reactome | R-HSA-8939902 | Regulation of RUNX2 expression and activity |
| reactome | R-HSA-8939902 | Regulation of RUNX2 expression and activity |
| reactome | R-HSA-8941858 | Regulation of RUNX3 expression and activity |
| reactome | R-HSA-9006936 | Signaling by TGF-beta family members |
| reactome | R-HSA-9006936 | Signaling by TGF-beta family members |
| reactome | R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation |
| reactome | R-HSA-983169 | Class I MHC mediated antigen processing & presentation |
| biocarta | efppathway | estrogen responsive protein efp controls cell cycle and breast tumors growth |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD405 | PIK-75 | 3 |
| iGMDRD79 | Gemcitabine | 2 |
| iGMDRD116 | CD437 | 3 |
| iGMDRD307 | Manumycin A | 2 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 3 |
| iGMDRD177 | Teniposide | 2 |
| iGMDRD351 | GW843682X | 2 |
| iGMDRD213 | SMR000068650 | 2 |
| iGMDRD289 | Parthenolide | 3 |
| iGMDRD137 | Indisulam | 7 |
| iGMDRD158 | NSC141540 | 6 |
| iGMDRD121 | GMX1778 | 1 |
| iGMDRD103 | SN-38 | 3 |
| iGMDRD322 | FK 866 | 3 |
| iGMDRD82 | Quiflapon | 2 |
| iGMDRD505 | Pevonedistat | 3 |
| iGMDRD300 | Tozasertib | 6 |
| iGMDRD329 | Merck60 | 2 |
| iGMDRD882 | CIL41 | 3 |
| iGMDRD286 | Nsc 632839 | 6 |
| iGMDRD579 | PF750 | 2 |
| iGMDRD772 | BRD4770 | 2 |
| iGMDRD193 | Fqi1 | 1 |
| iGMDRD316 | N9-Isopropyl-olomoucine | 2 |
| iGMDRD201 | SKI II | 2 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD52 | Rotenone | 2 |
| iGMDRD441 | TW 37 | 1 |
| iGMDRD318 | PAC-1 | 3 |
| iGMDRD171 | Pemetrexed | 2 |
| iGMDRD255 | SB225002 | 5 |
| iGMDRD270 | Ciclosporin | 2 |
| iGMDRD23 | Gossypol | 3 |
| iGMDRD268 | Cerulenin | 3 |
| iGMDRD60 | Quinoclamine | 1 |
| iGMDRD690 | PRIMA-1MET | 2 |
| iGMDRD888 | Compound 44 | 1 |
| iGMDRD506 | Fedratinib | 2 |
| iGMDRD887 | Compound 23 citrate | 3 |
| iGMDRD74 | Idarubicin | 3 |
| iGMDRD100 | Zebularine | 2 |
| iGMDRD188 | Piperlongumine | 4 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SMURF1
CLASSFICATION
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