SMURF1

Summary: This gene encodes a ubiquitin ligase that is specific for receptor-regulated SMAD proteins in the bone morphogenetic protein (BMP) pathway. This protein plays a key roll in the regulation of cell motility, cell signalling, and cell polarity. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Dec 2010].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameSMAD specific E3 ubiquitin protein ligase 1
OMIM IDMIM:605568
Ensembl IDEnsembl:ENSG00000198742
HGNC IDHGNC:HGNC:16807
PHARMGKB IDPA134987175
Map Location7q22.1

GO terms in SMURF1


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IDA GO:0004842 ubiquitin-protein transferase activity
MF IPI GO:0005515 protein binding
MF TAS GO:0005543 phospholipid binding
MF NAS GO:0048185 activin binding
MF IBA GO:0061630 ubiquitin protein ligase activity
MF IDA GO:0061630 ubiquitin protein ligase activity
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Gene expression in normal tissue: SMURF1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined28Biosynthesis of secondary metabolites2Apoptosis regulation2DNA replication2One carbon pool by folate1Other, kinases1Th17 cell differentiation1Metabolism1Purine metabolism1Cell cycle1

Pathways in SMURF1


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Database
Pathway ID
Pathway Des.
netpath Pathway_TGF_beta_Receptor TGF_beta_Receptor
pid bmppathway BMP receptor signaling
pid hdac_classi_pathway Signaling events mediated by HDAC Class I
pid tgfbrpathway TGF-beta receptor signaling
kegg hsa04120 Ubiquitin mediated proteolysis - Homo sapiens (human)
kegg hsa04144 Endocytosis - Homo sapiens (human)
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD405 PIK-75 3
iGMDRD79 Gemcitabine 2
iGMDRD116 CD437 3
iGMDRD307 Manumycin A 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SMURF1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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