JAK1

Summary: This gene encodes a membrane protein that is a member of a class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The encoded kinase phosphorylates STAT proteins (signal transducers and activators of transcription) and plays a key role in interferon-alpha/beta and interferon-gamma signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameJanus kinase 1
OMIM IDMIM:147795
Ensembl IDEnsembl:ENSG00000162434
HGNC IDHGNC:HGNC:6190
PHARMGKB IDPA29988
Map Location1p31.3

GO terms in JAK1


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Term Type
Evidence Type
GO Term ID
GO Des.
MF EXP GO:0004713 protein tyrosine kinase activity
MF TAS GO:0004713 protein tyrosine kinase activity
MF TAS GO:0004715 non-membrane spanning protein tyrosine kinase activity
MF TAS GO:0005088 Ras guanyl-nucleotide exchange factor activity
MF IBA GO:0005131 growth hormone receptor binding
MF ISS GO:0005131 growth hormone receptor binding
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Gene expression in normal tissue: JAK1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined27Other, kinases2Cell cycle1Th17 cell differentiation1Biosynthesis of secondary metabolites1Apoptosis regulation1

Pathways in JAK1


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Database
Pathway ID
Pathway Des.
reactome R-HSA-1059683 Interleukin-6 signaling
reactome R-HSA-1059683 Interleukin-6 signaling
reactome R-HSA-110056 MAPK3 (ERK1) activation
reactome R-HSA-112409 RAF-independent MAPK1/3 activation
reactome R-HSA-112411 MAPK1 (ERK2) activation
reactome R-HSA-1169408 ISG15 antiviral mechanism
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD782 DC-45-A2 3
iGMDRD441 TW 37 3
iGMDRD870 BRD63610 3
iGMDRD574 Ruxolitinib 5
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in JAK1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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