JAK1
Summary: This gene encodes a membrane protein that is a member of a class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The encoded kinase phosphorylates STAT proteins (signal transducers and activators of transcription) and plays a key role in interferon-alpha/beta and interferon-gamma signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| Janus kinase 1 | MIM:147795 | Ensembl:ENSG00000162434 | HGNC:HGNC:6190 | PA29988 | 1p31.3 |
GO terms in JAK1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | EXP | GO:0004713 | protein tyrosine kinase activity |
| MF | TAS | GO:0004713 | protein tyrosine kinase activity |
| MF | TAS | GO:0004715 | non-membrane spanning protein tyrosine kinase activity |
| MF | TAS | GO:0005088 | Ras guanyl-nucleotide exchange factor activity |
| MF | IBA | GO:0005131 | growth hormone receptor binding |
| MF | ISS | GO:0005131 | growth hormone receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IPI | GO:0019903 | protein phosphatase binding |
| MF | IPI | GO:0031625 | ubiquitin protein ligase binding |
| MF | IEA | GO:0031730 | CCR5 chemokine receptor binding |
| MF | IEA | GO:0046872 | metal ion binding |
| BP | TAS | GO:0000165 | MAPK cascade |
| BP | TAS | GO:0006468 | protein phosphorylation |
| BP | IBA | GO:0019221 | cytokine-mediated signaling pathway |
| BP | TAS | GO:0019221 | cytokine-mediated signaling pathway |
| BP | TAS | GO:0035556 | intracellular signal transduction |
| BP | TAS | GO:0035722 | interleukin-12-mediated signaling pathway |
| BP | TAS | GO:0035723 | interleukin-15-mediated signaling pathway |
| BP | IDA | GO:0038110 | interleukin-2-mediated signaling pathway |
| BP | TAS | GO:0038110 | interleukin-2-mediated signaling pathway |
| BP | TAS | GO:0038111 | interleukin-7-mediated signaling pathway |
| BP | TAS | GO:0038113 | interleukin-9-mediated signaling pathway |
| BP | TAS | GO:0038114 | interleukin-21-mediated signaling pathway |
| BP | IDA | GO:0046677 | response to antibiotic |
| BP | TAS | GO:0060333 | interferon-gamma-mediated signaling pathway |
| BP | TAS | GO:0060334 | regulation of interferon-gamma-mediated signaling pathway |
| BP | TAS | GO:0060337 | type I interferon signaling pathway |
| BP | TAS | GO:0070102 | interleukin-6-mediated signaling pathway |
| BP | TAS | GO:0070106 | interleukin-27-mediated signaling pathway |
| BP | TAS | GO:0070757 | interleukin-35-mediated signaling pathway |
| BP | IGI | GO:1903672 | positive regulation of sprouting angiogenesis |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005768 | endosome |
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0005856 | cytoskeleton |
| CC | HDA | GO:0005925 | focal adhesion |
Gene expression in normal tissue: JAK1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in JAK1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1059683 | Interleukin-6 signaling |
| reactome | R-HSA-1059683 | Interleukin-6 signaling |
| reactome | R-HSA-110056 | MAPK3 (ERK1) activation |
| reactome | R-HSA-112409 | RAF-independent MAPK1/3 activation |
| reactome | R-HSA-112411 | MAPK1 (ERK2) activation |
| reactome | R-HSA-1169408 | ISG15 antiviral mechanism |
| reactome | R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes |
| reactome | R-HSA-1266695 | Interleukin-7 signaling |
| reactome | R-HSA-1266695 | Interleukin-7 signaling |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-447115 | Interleukin-12 family signaling |
| reactome | R-HSA-447115 | Interleukin-12 family signaling |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-449836 | Other interleukin signaling |
| reactome | R-HSA-451927 | Interleukin-2 family signaling |
| reactome | R-HSA-451927 | Interleukin-2 family signaling |
| reactome | R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling |
| reactome | R-HSA-5673001 | RAF/MAP kinase cascade |
| reactome | R-HSA-5683057 | MAPK family signaling cascades |
| reactome | R-HSA-5684996 | MAPK1/MAPK3 signaling |
| reactome | R-HSA-6783589 | Interleukin-6 family signaling |
| reactome | R-HSA-6783589 | Interleukin-6 family signaling |
| reactome | R-HSA-6783783 | Interleukin-10 signaling |
| reactome | R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling |
| reactome | R-HSA-6788467 | IL-6-type cytokine receptor ligand interactions |
| reactome | R-HSA-877300 | Interferon gamma signaling |
| reactome | R-HSA-877300 | Interferon gamma signaling |
| reactome | R-HSA-877312 | Regulation of IFNG signaling |
| reactome | R-HSA-877312 | Regulation of IFNG signaling |
| reactome | R-HSA-8854691 | Interleukin-20 family signaling |
| reactome | R-HSA-8983432 | Interleukin-15 signaling |
| reactome | R-HSA-8983432 | Interleukin-15 signaling |
| reactome | R-HSA-8984722 | Interleukin-35 Signalling |
| reactome | R-HSA-8985947 | Interleukin-9 signaling |
| reactome | R-HSA-9020558 | Interleukin-2 signaling |
| reactome | R-HSA-9020591 | Interleukin-12 signaling |
| reactome | R-HSA-9020591 | Interleukin-12 signaling |
| reactome | R-HSA-9020956 | Interleukin-27 signaling |
| reactome | R-HSA-9020956 | Interleukin-27 signaling |
| reactome | R-HSA-9020958 | Interleukin-21 signaling |
| reactome | R-HSA-909733 | Interferon alpha/beta signaling |
| reactome | R-HSA-909733 | Interferon alpha/beta signaling |
| reactome | R-HSA-912526 | Interleukin receptor SHC signaling |
| reactome | R-HSA-912694 | Regulation of IFNA signaling |
| reactome | R-HSA-912694 | Regulation of IFNA signaling |
| reactome | R-HSA-913531 | Interferon Signaling |
| reactome | R-HSA-913531 | Interferon Signaling |
| biocarta | egfpathway | egf signaling pathway |
| biocarta | her2pathway | role of erbb2 in signal transduction and oncology |
| biocarta | ifnapathway | ifn alpha signaling pathway |
| biocarta | ifngpathway | ifn gamma signaling pathway |
| biocarta | il10pathway | il-10 anti-inflammatory signaling pathway |
| biocarta | il22bppathway | il22 soluble receptor signaling pathway |
| biocarta | il2pathway | il 2 signaling pathway |
| biocarta | il2rbpathway | il-2 receptor beta chain in t cell activation |
| biocarta | il4pathway | il 4 signaling pathway |
| biocarta | il6pathway | il 6 signaling pathway |
| biocarta | il7pathway | il-7 signal transduction |
| biocarta | pdgfpathway | pdgf signaling pathway |
| biocarta | stat3pathway | stat3 signaling pathway |
| pid | ifngpathway | IFN-gamma pathway |
| pid | il27pathway | IL27-mediated signaling events |
| pid | il2_1pathway | IL2-mediated signaling events |
| pid | il2_pi3kpathway | IL2 signaling events mediated by PI3K |
| pid | il2_stat5pathway | IL2 signaling events mediated by STAT5 |
| pid | il4_2pathway | IL4-mediated signaling events |
| pid | il6_7pathway | IL6-mediated signaling events |
| pid | p73pathway | p73 transcription factor network |
| pid | pdgfrapathway | PDGFR-alpha signaling pathway |
| pid | shp2_pathway | SHP2 signaling |
| pid | tcptp_pathway | Signaling events mediated by TCPTP |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa04217 | Necroptosis - Homo sapiens (human) |
| kegg | hsa04380 | Osteoclast differentiation - Homo sapiens (human) |
| kegg | hsa04550 | Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human) |
| kegg | hsa04621 | NOD-like receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04630 | Jak-STAT signaling pathway - Homo sapiens (human) |
| kegg | hsa04658 | Th1 and Th2 cell differentiation - Homo sapiens (human) |
| kegg | hsa04659 | Th17 cell differentiation - Homo sapiens (human) |
| kegg | hsa05140 | Leishmaniasis - Homo sapiens (human) |
| kegg | hsa05145 | Toxoplasmosis - Homo sapiens (human) |
| kegg | hsa05152 | Tuberculosis - Homo sapiens (human) |
| kegg | hsa05160 | Hepatitis C - Homo sapiens (human) |
| kegg | hsa05161 | Hepatitis B - Homo sapiens (human) |
| kegg | hsa05162 | Measles - Homo sapiens (human) |
| kegg | hsa05164 | Influenza A - Homo sapiens (human) |
| kegg | hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| kegg | hsa05166 | HTLV-I infection - Homo sapiens (human) |
| kegg | hsa05167 | Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human) |
| kegg | hsa05168 | Herpes simplex infection - Homo sapiens (human) |
| kegg | hsa05169 | Epstein-Barr virus infection - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05203 | Viral carcinogenesis - Homo sapiens (human) |
| kegg | hsa05212 | Pancreatic cancer - Homo sapiens (human) |
| pharmgkb | PA162356267 | EGFR Inhibitor Pathway, Pharmacodynamics |
| netpath | Pathway_EGFR1 | EGFR1 |
| netpath | Pathway_IL-7 | IL-7 |
| netpath | Pathway_IL11 | IL11 |
| netpath | Pathway_IL2 | IL2 |
| netpath | Pathway_IL4 | IL4 |
| netpath | Pathway_IL5 | IL5 |
| netpath | Pathway_IL6 | IL6 |
| netpath | Pathway_IL9 | IL9 |
| netpath | Pathway_Leptin | Leptin |
| netpath | Pathway_Oncostatin_M | Oncostatin_M |
| netpath | Pathway_Prolactin | Prolactin |
| netpath | Pathway_TSLP | TSLP |
| wikipathways | WP127 | IL-5 Signaling Pathway |
| wikipathways | WP2032 | Human Thyroid Stimulating Hormone (TSH) signaling pathway |
| wikipathways | WP2034 | Leptin signaling pathway |
| wikipathways | WP2037 | Prolactin Signaling Pathway |
| wikipathways | WP205 | IL-7 Signaling Pathway |
| wikipathways | WP2112 | IL17 signaling pathway |
| wikipathways | WP2113 | Type III interferon signaling |
| wikipathways | WP22 | IL-9 Signaling Pathway |
| wikipathways | WP2203 | Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway |
| wikipathways | WP2332 | Interleukin-11 Signaling Pathway |
| wikipathways | WP2374 | Oncostatin M Signaling Pathway |
| wikipathways | WP2593 | JAK-STAT |
| wikipathways | WP286 | IL-3 Signaling Pathway |
| wikipathways | WP2868 | TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer |
| wikipathways | WP364 | IL-6 signaling pathway |
| wikipathways | WP3646 | Hepatitis C and Hepatocellular Carcinoma |
| wikipathways | WP3931 | ESC Pluripotency Pathways |
| wikipathways | WP3932 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| wikipathways | WP395 | IL-4 Signaling Pathway |
| wikipathways | WP3972 | PDGFR-beta pathway |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| wikipathways | WP4197 | The human immune response to tuberculosis |
| wikipathways | WP437 | EGF-EGFR Signaling Pathway |
| wikipathways | WP49 | IL-2 Signaling Pathway |
| wikipathways | WP560 | TGF-beta Receptor Signaling |
| wikipathways | WP585 | Interferon type I signaling pathways |
| wikipathways | WP619 | Type II interferon signaling (IFNG) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD782 | DC-45-A2 | 3 |
| iGMDRD441 | TW 37 | 3 |
| iGMDRD870 | BRD63610 | 3 |
| iGMDRD574 | Ruxolitinib | 5 |
| iGMDRD52 | Rotenone | 2 |
| iGMDRD270 | Ciclosporin | 1 |
| iGMDRD802 | 4-methylfasudil | 1 |
| iGMDRD369 | TGX-115 | 3 |
| iGMDRD978 | Pembrolizumab | 1 |
| iGMDRD100 | Zebularine | 2 |
| iGMDRD188 | Piperlongumine | 4 |
| iGMDRD74 | Idarubicin | 2 |
| iGMDRD888 | Compound 44 | 1 |
| iGMDRD494 | Neopeltolide | 3 |
| iGMDRD974 | PD1 blockade | 1 |
| iGMDRD772 | BRD4770 | 2 |
| iGMDRD579 | PF750 | 8 |
| iGMDRD634 | SCHEMBL2608041 | 3 |
| iGMDRD130 | Enzastaurin | 1 |
| iGMDRD201 | SKI II | 2 |
| iGMDRD316 | N9-Isopropyl-olomoucine | 2 |
| iGMDRD231 | Importazole | 5 |
| iGMDRD213 | SMR000068650 | 2 |
| iGMDRD975 | PD-1 Inhibitor | 1 |
| iGMDRD886 | Compound 1541A | 2 |
| iGMDRD552 | AZD-1775 | 2 |
| iGMDRD82 | Quiflapon | 2 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD872 | BRD7137 | 3 |
| iGMDRD583 | LDN 193189 | 2 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD148 | Pifithrin-mu | 3 |
| iGMDRD351 | GW843682X | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in JAK1
CLASSFICATION
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