FOXO1


Summary: This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
forkhead box O1MIM:136533Ensembl:ENSG00000150907HGNC:HGNC:3819PA2823713q14.11

GO terms in FOXO1


Term TypeEvidence TypeGO Term IDGO Des.
BPIBAGO:0000122negative regulation of transcription by RNA polymerase II
BPIEAGO:0000122negative regulation of transcription by RNA polymerase II
BPIEAGO:0001568blood vessel development
BPISSGO:0001659temperature homeostasis
BPISSGO:0001678cellular glucose homeostasis
BPIEAGO:0006351transcription, DNA-templated
BPISSGO:0006473protein acetylation
BPIEAGO:0006914autophagy
BPIEAGO:0006915apoptotic process
BPISSGO:0006974cellular response to DNA damage stimulus
BPIBAGO:0008286insulin receptor signaling pathway
BPISSGO:0008286insulin receptor signaling pathway
BPIDAGO:0009267cellular response to starvation
BPISSGO:0009267cellular response to starvation
BPIMPGO:0010508positive regulation of autophagy
BPTASGO:0019221cytokine-mediated signaling pathway
BPTASGO:0031018endocrine pancreas development
BPISSGO:0032869cellular response to insulin stimulus
BPIDAGO:0032873negative regulation of stress-activated MAPK cascade
BPISSGO:0034599cellular response to oxidative stress
BPIEAGO:0035947regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter
BPIBAGO:0042593glucose homeostasis
BPIMPGO:0043065positive regulation of apoptotic process
BPIDAGO:0043066negative regulation of apoptotic process
BPISSGO:0045444fat cell differentiation
BPISSGO:0045599negative regulation of fat cell differentiation
BPIEAGO:0045722positive regulation of gluconeogenesis
BPIMPGO:0045732positive regulation of protein catabolic process
BPISSGO:0045892negative regulation of transcription, DNA-templated
BPIDAGO:0045893positive regulation of transcription, DNA-templated
BPIBAGO:0045944positive regulation of transcription by RNA polymerase II
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
BPIEAGO:0070166enamel mineralization
BPIEAGO:0070301cellular response to hydrogen peroxide
BPISSGO:0070417cellular response to cold
BPIDAGO:0071455cellular response to hyperoxia
BPIEAGO:0071549cellular response to dexamethasone stimulus
BPISSGO:0071732cellular response to nitric oxide
BPIEAGO:0090090negative regulation of canonical Wnt signaling pathway
BPISSGO:0097009energy homeostasis
BPIEAGO:0097150neuronal stem cell population maintenance
BPIEAGO:1902617response to fluoride
BPISSGO:1903243negative regulation of cardiac muscle hypertrophy in response to stress
BPIEAGO:2000177regulation of neural precursor cell proliferation
BPIEAGO:2000377regulation of reactive oxygen species metabolic process
CCIBAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCTASGO:0005654nucleoplasm
CCIBAGO:0005737cytoplasm
CCIDAGO:0005737cytoplasm
CCISSGO:0005739mitochondrion
CCISSGO:0005829cytosol
CCTASGO:0005829cytosol
MFIBAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIEAGO:0000989transcription factor activity, transcription factor binding
MFIEAGO:0001078transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MFIEAGO:0001223transcription coactivator binding
MFISSGO:0003682chromatin binding
MFIBAGO:0003700DNA-binding transcription factor activity
MFIPIGO:0005515protein binding
MFIDAGO:0008013beta-catenin binding
MFIBAGO:0008134transcription factor binding
MFIPIGO:0031625ubiquitin protein ligase binding
MFIBAGO:0043565sequence-specific DNA binding
MFIDAGO:0043565sequence-specific DNA binding
MFISSGO:0051721protein phosphatase 2A binding

Gene expression in normal tissue: FOXO1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in FOXO1


DatabasePathway IDPathway Des.
biocartaaktpathwayakt signaling pathway
reactomeR-HSA-1257604PIP3 activates AKT signaling
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1643685Disease
reactomeR-HSA-168256Immune System
reactomeR-HSA-186712Regulation of beta-cell development
reactomeR-HSA-186712Regulation of beta-cell development
reactomeR-HSA-198693AKT phosphorylates targets in the nucleus
reactomeR-HSA-210745Regulation of gene expression in beta cells
reactomeR-HSA-210745Regulation of gene expression in beta cells
reactomeR-HSA-211163AKT-mediated inactivation of FOXO1A
reactomeR-HSA-2219528PI3K/AKT Signaling in Cancer
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-5663202Diseases of signal transduction
reactomeR-HSA-5674400Constitutive Signaling by AKT1 E17K in Cancer
reactomeR-HSA-5683057MAPK family signaling cascades
reactomeR-HSA-5687128MAPK6/MAPK4 signaling
reactomeR-HSA-6785807Interleukin-4 and Interleukin-13 signaling
reactomeR-HSA-9006925Intracellular signaling by second messengers
wikipathwaysWP138Androgen receptor signaling pathway
wikipathwaysWP1541Energy Metabolism
wikipathwaysWP1984Integrated Breast Cancer Pathway
wikipathwaysWP2034Leptin signaling pathway
wikipathwaysWP2035Follicle Stimulating Hormone (FSH) signaling pathway
wikipathwaysWP2261Signaling Pathways in Glioblastoma
wikipathwaysWP23B Cell Receptor Signaling Pathway
wikipathwaysWP2324AGE-RAGE pathway
wikipathwaysWP236Adipogenesis
wikipathwaysWP2593JAK-STAT
wikipathwaysWP2875Constitutive Androstane Receptor Pathway
wikipathwaysWP2876Pregnane X Receptor pathway
wikipathwaysWP2877Vitamin D Receptor Pathway
wikipathwaysWP2882Nuclear Receptors Meta-Pathway
wikipathwaysWP3286Copper homeostasis
wikipathwaysWP3298Melatonin metabolism and effects
wikipathwaysWP3303Rac1-Pak1-p38-MMP-2 pathway
wikipathwaysWP3599Transcription factor regulation in adipogenesis
wikipathwaysWP3630NAD metabolism, sirtuins and aging
wikipathwaysWP3844PI3K-AKT-mTOR signaling pathway and therapeutic opportunities
wikipathwaysWP3876BMP2-WNT4-FOXO1 Pathway in Human Primary Endometrial Stromal Cell Differentiation
wikipathwaysWP3888VEGFA-VEGFR2 Signaling Pathway
wikipathwaysWP3915Angiopoietin Like Protein 8 Regulatory Pathway
wikipathwaysWP3932Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathwaysWP3946White fat cell differentiation
wikipathwaysWP3981miRNA regulation of prostate cancer signaling pathways
wikipathwaysWP4010Liver steatosis AOP
wikipathwaysWP4066Interleukin-4 and 13 signaling
wikipathwaysWP4149White fat cell differentiation
wikipathwaysWP4186Somatroph axis (GH) and its relationship to dietary restriction and aging
wikipathwaysWP437EGF-EGFR Signaling Pathway
wikipathwaysWP481Insulin Signaling
wikipathwaysWP673ErbB Signaling Pathway
pidangiopoietinreceptor_pathwayAngiopoietin receptor Tie2-mediated signaling
pidar_tf_pathwayRegulation of Androgen receptor activity
pidcxcr4_pathwayCXCR4-mediated signaling events
pidfoxopathwayFoxO family signaling
pidhdac_classiii_pathwaySignaling events mediated by HDAC Class III
pidil6_7pathwayIL6-mediated signaling events
pidpi3kciaktpathwayClass I PI3K signaling events mediated by Akt
pidsmad2_3nuclearpathwayRegulation of nuclear SMAD2/3 signaling
netpathPathway_BCRBCR
netpathPathway_EGFR1EGFR1
netpathPathway_FSHFSH
netpathPathway_IL-7IL-7
netpathPathway_IL3IL3
netpathPathway_IL6IL6
netpathPathway_LeptinLeptin
netpathPathway_TGF_beta_ReceptorTGF_beta_Receptor
netpathPathway_TNFalphaTNFalpha
kegghsa04068FoxO signaling pathway - Homo sapiens (human)
kegghsa04152AMPK signaling pathway - Homo sapiens (human)
kegghsa04211Longevity regulating pathway - Homo sapiens (human)
kegghsa04213Longevity regulating pathway - multiple species - Homo sapiens (human)
kegghsa04218Cellular senescence - Homo sapiens (human)
kegghsa04910Insulin signaling pathway - Homo sapiens (human)
kegghsa04919Thyroid hormone signaling pathway - Homo sapiens (human)
kegghsa04922Glucagon signaling pathway - Homo sapiens (human)
kegghsa04931Insulin resistance - Homo sapiens (human)
kegghsa04933AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)
kegghsa05165Human papillomavirus infection - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05202Transcriptional misregulation in cancer - Homo sapiens (human)
kegghsa05215Prostate cancer - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD329Merck601
iGMDRD577BIX012942
iGMDRD780PP-301
iGMDRD286Nsc 6328397
iGMDRD871BRD63683
iGMDRD188Piperlongumine1
iGMDRD74Idarubicin3
iGMDRD451Serdemetan1
iGMDRD690PRIMA-1MET3
iGMDRD147Prima-11
iGMDRD5Tyrphostin AG 14781
iGMDRD220fumonisin B13
iGMDRD137Indisulam2
iGMDRD8012,4-dideoxy-DC-45-A23
iGMDRD294Batimastat3
iGMDRD213SMR0000686503
iGMDRD6AM-5803
iGMDRD705Nakiterpiosin2
iGMDRD171Pemetrexed3
iGMDRD434BMS-5369243
iGMDRD132(-)-gallocatechin-3-O-gallate1
iGMDRD280CYTOCHALASIN B2
iGMDRD607Ubistatin B3
iGMDRD512nutlin 33
iGMDRD889Compound 7d-cis1
iGMDRD772BRD47703
iGMDRD425ERASTIN3
iGMDRD126Tipifarnib1
iGMDRD781Sirolimus1
iGMDRD150RITA3
iGMDRD532Olaparib3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FOXO1

​​​​