FOXO1
Summary: This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| forkhead box O1 | MIM:136533 | Ensembl:ENSG00000150907 | HGNC:HGNC:3819 | PA28237 | 13q14.11 |
Gene Categories:
TRANSCRIPTION FACTOR BINDINGGO terms in FOXO1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IBA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0001568 | blood vessel development |
| BP | ISS | GO:0001659 | temperature homeostasis |
| BP | ISS | GO:0001678 | cellular glucose homeostasis |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | ISS | GO:0006473 | protein acetylation |
| BP | IEA | GO:0006914 | autophagy |
| BP | IEA | GO:0006915 | apoptotic process |
| BP | ISS | GO:0006974 | cellular response to DNA damage stimulus |
| BP | IBA | GO:0008286 | insulin receptor signaling pathway |
| BP | ISS | GO:0008286 | insulin receptor signaling pathway |
| BP | IDA | GO:0009267 | cellular response to starvation |
| BP | ISS | GO:0009267 | cellular response to starvation |
| BP | IMP | GO:0010508 | positive regulation of autophagy |
| BP | TAS | GO:0019221 | cytokine-mediated signaling pathway |
| BP | TAS | GO:0031018 | endocrine pancreas development |
| BP | ISS | GO:0032869 | cellular response to insulin stimulus |
| BP | IDA | GO:0032873 | negative regulation of stress-activated MAPK cascade |
| BP | ISS | GO:0034599 | cellular response to oxidative stress |
| BP | IEA | GO:0035947 | regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter |
| BP | IBA | GO:0042593 | glucose homeostasis |
| BP | IMP | GO:0043065 | positive regulation of apoptotic process |
| BP | IDA | GO:0043066 | negative regulation of apoptotic process |
| BP | ISS | GO:0045444 | fat cell differentiation |
| BP | ISS | GO:0045599 | negative regulation of fat cell differentiation |
| BP | IEA | GO:0045722 | positive regulation of gluconeogenesis |
| BP | IMP | GO:0045732 | positive regulation of protein catabolic process |
| BP | ISS | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | IDA | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IBA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0070166 | enamel mineralization |
| BP | IEA | GO:0070301 | cellular response to hydrogen peroxide |
| BP | ISS | GO:0070417 | cellular response to cold |
| BP | IDA | GO:0071455 | cellular response to hyperoxia |
| BP | IEA | GO:0071549 | cellular response to dexamethasone stimulus |
| BP | ISS | GO:0071732 | cellular response to nitric oxide |
| BP | IEA | GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| BP | ISS | GO:0097009 | energy homeostasis |
| BP | IEA | GO:0097150 | neuronal stem cell population maintenance |
| BP | IEA | GO:1902617 | response to fluoride |
| BP | ISS | GO:1903243 | negative regulation of cardiac muscle hypertrophy in response to stress |
| BP | IEA | GO:2000177 | regulation of neural precursor cell proliferation |
| BP | IEA | GO:2000377 | regulation of reactive oxygen species metabolic process |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | ISS | GO:0005739 | mitochondrion |
| CC | ISS | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| MF | IBA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IEA | GO:0000989 | transcription factor activity, transcription factor binding |
| MF | IEA | GO:0001078 | transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IEA | GO:0001223 | transcription coactivator binding |
| MF | ISS | GO:0003682 | chromatin binding |
| MF | IBA | GO:0003700 | DNA-binding transcription factor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0008013 | beta-catenin binding |
| MF | IBA | GO:0008134 | transcription factor binding |
| MF | IPI | GO:0031625 | ubiquitin protein ligase binding |
| MF | IBA | GO:0043565 | sequence-specific DNA binding |
| MF | IDA | GO:0043565 | sequence-specific DNA binding |
| MF | ISS | GO:0051721 | protein phosphatase 2A binding |
Gene expression in normal tissue: FOXO1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in FOXO1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | aktpathway | akt signaling pathway |
| reactome | R-HSA-1257604 | PIP3 activates AKT signaling |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-186712 | Regulation of beta-cell development |
| reactome | R-HSA-186712 | Regulation of beta-cell development |
| reactome | R-HSA-198693 | AKT phosphorylates targets in the nucleus |
| reactome | R-HSA-210745 | Regulation of gene expression in beta cells |
| reactome | R-HSA-210745 | Regulation of gene expression in beta cells |
| reactome | R-HSA-211163 | AKT-mediated inactivation of FOXO1A |
| reactome | R-HSA-2219528 | PI3K/AKT Signaling in Cancer |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| reactome | R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer |
| reactome | R-HSA-5683057 | MAPK family signaling cascades |
| reactome | R-HSA-5687128 | MAPK6/MAPK4 signaling |
| reactome | R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling |
| reactome | R-HSA-9006925 | Intracellular signaling by second messengers |
| wikipathways | WP138 | Androgen receptor signaling pathway |
| wikipathways | WP1541 | Energy Metabolism |
| wikipathways | WP1984 | Integrated Breast Cancer Pathway |
| wikipathways | WP2034 | Leptin signaling pathway |
| wikipathways | WP2035 | Follicle Stimulating Hormone (FSH) signaling pathway |
| wikipathways | WP2261 | Signaling Pathways in Glioblastoma |
| wikipathways | WP23 | B Cell Receptor Signaling Pathway |
| wikipathways | WP2324 | AGE-RAGE pathway |
| wikipathways | WP236 | Adipogenesis |
| wikipathways | WP2593 | JAK-STAT |
| wikipathways | WP2875 | Constitutive Androstane Receptor Pathway |
| wikipathways | WP2876 | Pregnane X Receptor pathway |
| wikipathways | WP2877 | Vitamin D Receptor Pathway |
| wikipathways | WP2882 | Nuclear Receptors Meta-Pathway |
| wikipathways | WP3286 | Copper homeostasis |
| wikipathways | WP3298 | Melatonin metabolism and effects |
| wikipathways | WP3303 | Rac1-Pak1-p38-MMP-2 pathway |
| wikipathways | WP3599 | Transcription factor regulation in adipogenesis |
| wikipathways | WP3630 | NAD metabolism, sirtuins and aging |
| wikipathways | WP3844 | PI3K-AKT-mTOR signaling pathway and therapeutic opportunities |
| wikipathways | WP3876 | BMP2-WNT4-FOXO1 Pathway in Human Primary Endometrial Stromal Cell Differentiation |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| wikipathways | WP3915 | Angiopoietin Like Protein 8 Regulatory Pathway |
| wikipathways | WP3932 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| wikipathways | WP3946 | White fat cell differentiation |
| wikipathways | WP3981 | miRNA regulation of prostate cancer signaling pathways |
| wikipathways | WP4010 | Liver steatosis AOP |
| wikipathways | WP4066 | Interleukin-4 and 13 signaling |
| wikipathways | WP4149 | White fat cell differentiation |
| wikipathways | WP4186 | Somatroph axis (GH) and its relationship to dietary restriction and aging |
| wikipathways | WP437 | EGF-EGFR Signaling Pathway |
| wikipathways | WP481 | Insulin Signaling |
| wikipathways | WP673 | ErbB Signaling Pathway |
| pid | angiopoietinreceptor_pathway | Angiopoietin receptor Tie2-mediated signaling |
| pid | ar_tf_pathway | Regulation of Androgen receptor activity |
| pid | cxcr4_pathway | CXCR4-mediated signaling events |
| pid | foxopathway | FoxO family signaling |
| pid | hdac_classiii_pathway | Signaling events mediated by HDAC Class III |
| pid | il6_7pathway | IL6-mediated signaling events |
| pid | pi3kciaktpathway | Class I PI3K signaling events mediated by Akt |
| pid | smad2_3nuclearpathway | Regulation of nuclear SMAD2/3 signaling |
| netpath | Pathway_BCR | BCR |
| netpath | Pathway_EGFR1 | EGFR1 |
| netpath | Pathway_FSH | FSH |
| netpath | Pathway_IL-7 | IL-7 |
| netpath | Pathway_IL3 | IL3 |
| netpath | Pathway_IL6 | IL6 |
| netpath | Pathway_Leptin | Leptin |
| netpath | Pathway_TGF_beta_Receptor | TGF_beta_Receptor |
| netpath | Pathway_TNFalpha | TNFalpha |
| kegg | hsa04068 | FoxO signaling pathway - Homo sapiens (human) |
| kegg | hsa04152 | AMPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04211 | Longevity regulating pathway - Homo sapiens (human) |
| kegg | hsa04213 | Longevity regulating pathway - multiple species - Homo sapiens (human) |
| kegg | hsa04218 | Cellular senescence - Homo sapiens (human) |
| kegg | hsa04910 | Insulin signaling pathway - Homo sapiens (human) |
| kegg | hsa04919 | Thyroid hormone signaling pathway - Homo sapiens (human) |
| kegg | hsa04922 | Glucagon signaling pathway - Homo sapiens (human) |
| kegg | hsa04931 | Insulin resistance - Homo sapiens (human) |
| kegg | hsa04933 | AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human) |
| kegg | hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05202 | Transcriptional misregulation in cancer - Homo sapiens (human) |
| kegg | hsa05215 | Prostate cancer - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD329 | Merck60 | 1 |
| iGMDRD577 | BIX01294 | 2 |
| iGMDRD780 | PP-30 | 1 |
| iGMDRD286 | Nsc 632839 | 7 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD188 | Piperlongumine | 1 |
| iGMDRD74 | Idarubicin | 3 |
| iGMDRD451 | Serdemetan | 1 |
| iGMDRD690 | PRIMA-1MET | 3 |
| iGMDRD147 | Prima-1 | 1 |
| iGMDRD5 | Tyrphostin AG 1478 | 1 |
| iGMDRD220 | fumonisin B1 | 3 |
| iGMDRD137 | Indisulam | 2 |
| iGMDRD801 | 2,4-dideoxy-DC-45-A2 | 3 |
| iGMDRD294 | Batimastat | 3 |
| iGMDRD213 | SMR000068650 | 3 |
| iGMDRD6 | AM-580 | 3 |
| iGMDRD705 | Nakiterpiosin | 2 |
| iGMDRD171 | Pemetrexed | 3 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 1 |
| iGMDRD280 | CYTOCHALASIN B | 2 |
| iGMDRD607 | Ubistatin B | 3 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD889 | Compound 7d-cis | 1 |
| iGMDRD772 | BRD4770 | 3 |
| iGMDRD425 | ERASTIN | 3 |
| iGMDRD126 | Tipifarnib | 1 |
| iGMDRD781 | Sirolimus | 1 |
| iGMDRD150 | RITA | 3 |
| iGMDRD532 | Olaparib | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in FOXO1
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.