FOXO1
Summary: This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma. [provided by RefSeq, Jul 2008].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
Nameforkhead box O1 OMIM IDMIM:136533 Ensembl IDEnsembl:ENSG00000150907 HGNC IDHGNC:HGNC:3819 PHARMGKB IDPA28237 Map Location13q14.11 | |||||
Gene Categories:
TRANSCRIPTION FACTOR BINDINGGO terms in FOXO1
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IBA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0001568 | blood vessel development |
| BP | ISS | GO:0001659 | temperature homeostasis |
| BP | ISS | GO:0001678 | cellular glucose homeostasis |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
Gene expression in normal tissue: FOXO1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in FOXO1
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | aktpathway | akt signaling pathway |
| reactome | R-HSA-1257604 | PIP3 activates AKT signaling |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-162582 | Signal Transduction |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in FOXO1
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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