MAP4K5
Summary: This gene encodes a member of the serine/threonine protein kinase family, that is highly similar to yeast SPS1/STE20 kinase. Yeast SPS1/STE20 functions near the beginning of the MAP kinase signal cascades that is essential for yeast pheromone response. This kinase was shown to activate Jun kinase in mammalian cells, which suggested a role in stress response. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| mitogen-activated protein kinase kinase kinase kinase 5 | MIM:604923 | Ensembl:ENSG00000012983 | HGNC:HGNC:6867 | PA30613 | 14q22.1 |
GO terms in MAP4K5
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0004672 | protein kinase activity |
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0005524 | ATP binding |
| MF | IBA | GO:0008349 | MAP kinase kinase kinase kinase activity |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| BP | IBA | GO:0000165 | MAPK cascade |
| BP | IEA | GO:0000185 | activation of MAPKKK activity |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | TAS | GO:0007257 | activation of JUN kinase activity |
| BP | IBA | GO:0007346 | regulation of mitotic cell cycle |
| BP | IBA | GO:0023014 | signal transduction by protein phosphorylation |
| BP | IBA | GO:0032147 | activation of protein kinase activity |
| BP | IDA | GO:0035556 | intracellular signal transduction |
Gene expression in normal tissue: MAP4K5
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MAP4K5
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | mapkpathway | mapkinase signaling pathway |
| wikipathways | WP3915 | Angiopoietin Like Protein 8 Regulatory Pathway |
| wikipathways | WP481 | Insulin Signaling |
| pid | tnfpathway | TNF receptor signaling pathway |
| netpath | Pathway_EGFR1 | EGFR1 |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD512 | nutlin 3 | 4 |
| iGMDRD84 | Lovastatin acid | 1 |
| iGMDRD405 | PIK-75 | 6 |
| iGMDRD560 | MK-2206 | 3 |
| iGMDRD351 | GW843682X | 6 |
| iGMDRD314 | Tanespimycin | 5 |
| iGMDRD341 | Triacsin c | 2 |
| iGMDRD435 | BI-2536 | 7 |
| iGMDRD154 | NSC23766 | 1 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD901 | ELCPK | 1 |
| iGMDRD158 | NSC141540 | 3 |
| iGMDRD137 | Indisulam | 5 |
| iGMDRD103 | SN-38 | 3 |
| iGMDRD267 | Oligomycin A | 2 |
| iGMDRD415 | LE-135 | 1 |
| iGMDRD481 | Dactolisib | 3 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD705 | Nakiterpiosin | 8 |
| iGMDRD329 | Merck60 | 6 |
| iGMDRD872 | BRD7137 | 2 |
| iGMDRD871 | BRD6368 | 1 |
| iGMDRD414 | MST-312 | 2 |
| iGMDRD505 | Pevonedistat | 4 |
| iGMDRD1008 | SR-II-138A | 3 |
| iGMDRD420 | Leucascandrolide A | 4 |
| iGMDRD151 | CHM-1 | 7 |
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD781 | Sirolimus | 2 |
| iGMDRD494 | Neopeltolide | 1 |
| iGMDRD670 | ML 210 | 2 |
| iGMDRD546 | BMS-754807 | 4 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD446 | LY 2183240 | 2 |
| iGMDRD634 | SCHEMBL2608041 | 2 |
| iGMDRD280 | CYTOCHALASIN B | 4 |
| iGMDRD466 | Chaetocin | 3 |
| iGMDRD260 | FQI-2 | 1 |
| iGMDRD802 | 4-methylfasudil | 2 |
| iGMDRD441 | TW 37 | 5 |
| iGMDRD171 | Pemetrexed | 1 |
| iGMDRD398 | Sepantronium | 2 |
| iGMDRD506 | Fedratinib | 8 |
| iGMDRD887 | Compound 23 citrate | 2 |
| iGMDRD399 | Selumetinib | 2 |
| iGMDRD74 | Idarubicin | 4 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD451 | Serdemetan | 2 |
| iGMDRD356 | PNU-74654 | 2 |
| iGMDRD64 | Parbendazole | 1 |
| iGMDRD369 | TGX-115 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MAP4K5
CLASSFICATION
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