MAP4K5


Summary: This gene encodes a member of the serine/threonine protein kinase family, that is highly similar to yeast SPS1/STE20 kinase. Yeast SPS1/STE20 functions near the beginning of the MAP kinase signal cascades that is essential for yeast pheromone response. This kinase was shown to activate Jun kinase in mammalian cells, which suggested a role in stress response. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
mitogen-activated protein kinase kinase kinase kinase 5MIM:604923Ensembl:ENSG00000012983HGNC:HGNC:6867PA3061314q22.1

GO terms in MAP4K5


Term TypeEvidence TypeGO Term IDGO Des.
MFTASGO:0004672protein kinase activity
MFIBAGO:0004674protein serine/threonine kinase activity
MFIDAGO:0004674protein serine/threonine kinase activity
MFIPIGO:0005515protein binding
MFIDAGO:0005524ATP binding
MFIBAGO:0008349MAP kinase kinase kinase kinase activity
CCIBAGO:0005737cytoplasm
CCIDAGO:0005737cytoplasm
BPIBAGO:0000165MAPK cascade
BPIEAGO:0000185activation of MAPKKK activity
BPIDAGO:0006468protein phosphorylation
BPTASGO:0007257activation of JUN kinase activity
BPIBAGO:0007346regulation of mitotic cell cycle
BPIBAGO:0023014signal transduction by protein phosphorylation
BPIBAGO:0032147activation of protein kinase activity
BPIDAGO:0035556intracellular signal transduction

Gene expression in normal tissue: MAP4K5

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MAP4K5


DatabasePathway IDPathway Des.
biocartamapkpathwaymapkinase signaling pathway
wikipathwaysWP3915Angiopoietin Like Protein 8 Regulatory Pathway
wikipathwaysWP481Insulin Signaling
pidtnfpathwayTNF receptor signaling pathway
netpathPathway_EGFR1EGFR1

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD512nutlin 34
iGMDRD84Lovastatin acid1
iGMDRD405PIK-756
iGMDRD560MK-22063
iGMDRD351GW843682X6
iGMDRD314Tanespimycin5
iGMDRD341Triacsin c2
iGMDRD435BI-25367
iGMDRD154NSC237661
iGMDRD123Isoevodiamine3
iGMDRD901ELCPK1
iGMDRD158NSC1415403
iGMDRD137Indisulam5
iGMDRD103SN-383
iGMDRD267Oligomycin A2
iGMDRD415LE-1351
iGMDRD481Dactolisib3
iGMDRD434BMS-5369242
iGMDRD705Nakiterpiosin8
iGMDRD329Merck606
iGMDRD872BRD71372
iGMDRD871BRD63681
iGMDRD414MST-3122
iGMDRD505Pevonedistat4
iGMDRD1008SR-II-138A3
iGMDRD420Leucascandrolide A4
iGMDRD151CHM-17
iGMDRD126Tipifarnib3
iGMDRD781Sirolimus2
iGMDRD494Neopeltolide1
iGMDRD670ML 2102
iGMDRD546BMS-7548074
iGMDRD193Fqi13
iGMDRD446LY 21832402
iGMDRD634SCHEMBL26080412
iGMDRD280CYTOCHALASIN B4
iGMDRD466Chaetocin3
iGMDRD260FQI-21
iGMDRD8024-methylfasudil2
iGMDRD441TW 375
iGMDRD171Pemetrexed1
iGMDRD398Sepantronium2
iGMDRD506Fedratinib8
iGMDRD887Compound 23 citrate2
iGMDRD399Selumetinib2
iGMDRD74Idarubicin4
iGMDRD188Piperlongumine2
iGMDRD451Serdemetan2
iGMDRD356PNU-746542
iGMDRD64Parbendazole1
iGMDRD369TGX-1152

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MAP4K5

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