SERPINA2
Summary: This gene encodes a member of the serpin family of proteins, a group of proteins that inhibit serine proteases. The encoded intracellular glycoprotein is localized at the endoplasmic reticulum. This gene is a polymorphic pseudogene, with the non-functional allele being predominant in some populations. Some individuals, as represented by the reference genome allele, contain a 2kb coding region deletion and a start code mutation. [provided by RefSeq, Feb 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| serpin family A member 2 (gene/pseudogene) | MIM:107410 | Ensembl:ENSG00000258597 | HGNC:HGNC:8985 | PA35520 | 14q32.13 |
GO terms in SERPINA2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0005615 | extracellular space |
| CC | IDA | GO:0005783 | endoplasmic reticulum |
| BP | IBA | GO:0010951 | negative regulation of endopeptidase activity |
| BP | IEA | GO:0010951 | negative regulation of endopeptidase activity |
| MF | IBA | GO:0004867 | serine-type endopeptidase inhibitor activity |
| MF | IPI | GO:0005515 | protein binding |
Gene expression in normal tissue: SERPINA2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SERPINA2
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD414 | MST-312 | 3 |
| iGMDRD882 | CIL41 | 2 |
| iGMDRD246 | NPC26 | 2 |
| iGMDRD42 | Vorinostat | 4 |
| iGMDRD384 | EHT-1864 | 1 |
| iGMDRD434 | BMS-536924 | 1 |
| iGMDRD504 | Obatoclax | 1 |
| iGMDRD389 | SB525334 | 1 |
| iGMDRD85 | Ursolic acid | 4 |
| iGMDRD57 | Chloropentafluorobenzene | 2 |
| iGMDRD901 | ELCPK | 3 |
| iGMDRD177 | Teniposide | 3 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 3 |
| iGMDRD382 | CEP-701 | 1 |
| iGMDRD307 | Manumycin A | 3 |
| iGMDRD486 | Tosedostat | 3 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD100 | Zebularine | 4 |
| iGMDRD887 | Compound 23 citrate | 1 |
| iGMDRD185 | DMOG | 1 |
| iGMDRD562 | Navitoclax | 2 |
| iGMDRD291 | AC1NS4S0 | 1 |
| iGMDRD451 | Serdemetan | 4 |
| iGMDRD138 | PX 12 | 4 |
| iGMDRD870 | BRD63610 | 2 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD253 | Vincaleukoblastine | 1 |
| iGMDRD686 | PF4708671 | 1 |
| iGMDRD281 | Vinorelbine base | 1 |
| iGMDRD193 | Fqi1 | 1 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD599 | Salermide | 5 |
| iGMDRD1008 | SR-II-138A | 3 |
| iGMDRD772 | BRD4770 | 3 |
| iGMDRD144 | NSC95397 | 2 |
| iGMDRD587 | CHEMBL585951 | 1 |
| iGMDRD494 | Neopeltolide | 2 |
| iGMDRD971 | PARP inhibitor | 1 |
| iGMDRD354 | Midostaurin | 1 |
| iGMDRD871 | BRD6368 | 1 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD662 | JQ-1 | 2 |
| iGMDRD329 | Merck60 | 1 |
| iGMDRD552 | AZD-1775 | 2 |
| iGMDRD263 | AACOCF3 | 2 |
| iGMDRD421 | AZD7762 | 2 |
| iGMDRD322 | FK 866 | 2 |
| iGMDRD173 | Epothilone B | 1 |
| iGMDRD137 | Indisulam | 5 |
| iGMDRD293 | Bleomycin | 1 |
| iGMDRD158 | NSC141540 | 3 |
| iGMDRD121 | GMX1778 | 4 |
| iGMDRD202 | Curcumin | 4 |
| iGMDRD5 | Tyrphostin AG 1478 | 5 |
| iGMDRD215 | CCT007093 | 1 |
| iGMDRD289 | Parthenolide | 5 |
| iGMDRD105 | Triptolide | 2 |
| iGMDRD705 | Nakiterpiosin | 2 |
| iGMDRD77 | Itraconazole | 2 |
| iGMDRD341 | Triacsin c | 6 |
| iGMDRD49 | Mitomycin | 1 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD511 | CHEMBL399379 | 3 |
| iGMDRD945 | ML214 | 7 |
| iGMDRD584 | VER 155008 | 2 |
| iGMDRD150 | RITA | 7 |
| iGMDRD532 | Olaparib | 4 |
| iGMDRD594 | AZD-8055 | 1 |
| iGMDRD79 | Gemcitabine | 4 |
| iGMDRD188 | Piperlongumine | 8 |
| iGMDRD74 | Idarubicin | 2 |
| iGMDRD399 | Selumetinib | 2 |
| iGMDRD888 | Compound 44 | 6 |
| iGMDRD780 | PP-30 | 6 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD23 | Gossypol | 3 |
| iGMDRD260 | FQI-2 | 2 |
| iGMDRD44 | Temozolomide | 2 |
| iGMDRD187 | BRD9876 | 5 |
| iGMDRD52 | Rotenone | 2 |
| iGMDRD61 | Kinetin riboside | 5 |
| iGMDRD466 | Chaetocin | 6 |
| iGMDRD126 | Tipifarnib | 4 |
| iGMDRD433 | Lexibulin | 3 |
| iGMDRD889 | Compound 7d-cis | 2 |
| iGMDRD420 | Leucascandrolide A | 2 |
| iGMDRD856 | BRD-K66532283 | 1 |
| iGMDRD427 | ABT737 | 3 |
| iGMDRD483 | SCH-529074 | 3 |
| iGMDRD781 | Sirolimus | 8 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SERPINA2
CLASSFICATION
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