RBL2
Summary:
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| RB transcriptional corepressor like 2 | MIM:180203 | Ensembl:ENSG00000103479 | HGNC:HGNC:9894 | PA34258 | 16q12.2 |
GO terms in RBL2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0006325 | chromatin organization |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IEA | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | TAS | GO:0006977 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest |
| BP | IBA | GO:0007346 | regulation of mitotic cell cycle |
| BP | IMP | GO:0010629 | negative regulation of gene expression |
| BP | IBA | GO:0030154 | cell differentiation |
| BP | IDA | GO:0043550 | regulation of lipid kinase activity |
| BP | IBA | GO:2000134 | negative regulation of G1/S transition of mitotic cell cycle |
| CC | IBA | GO:0000785 | chromatin |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005667 | transcription factor complex |
| CC | IEA | GO:0005667 | transcription factor complex |
| CC | IDA | GO:0005730 | nucleolus |
| CC | IDA | GO:0005829 | cytosol |
| CC | HDA | GO:0070062 | extracellular exosome |
| MF | IBA | GO:0001012 | RNA polymerase II regulatory region DNA binding |
| MF | IBA | GO:0001078 | transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IBA | GO:0001102 | RNA polymerase II activating transcription factor binding |
| MF | IEA | GO:0003677 | DNA binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:1990841 | promoter-specific chromatin binding |
Gene expression in normal tissue: RBL2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RBL2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | e2f_pathway | E2F transcription factor network |
| pid | foxopathway | FoxO family signaling |
| kegg | hsa04068 | FoxO signaling pathway - Homo sapiens (human) |
| kegg | hsa04110 | Cell cycle - Homo sapiens (human) |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa04218 | Cellular senescence - Homo sapiens (human) |
| kegg | hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| kegg | hsa05203 | Viral carcinogenesis - Homo sapiens (human) |
| netpath | Pathway_ID | ID |
| netpath | Pathway_TGF_beta_Receptor | TGF_beta_Receptor |
| wikipathways | WP2032 | Human Thyroid Stimulating Hormone (TSH) signaling pathway |
| wikipathways | WP236 | Adipogenesis |
| wikipathways | WP366 | TGF-beta Signaling Pathway |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| wikipathways | WP53 | ID signaling pathway |
| wikipathways | WP710 | DNA Damage Response (only ATM dependent) |
| wikipathways | WP727 | Monoamine Transport |
| reactome | R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex |
| reactome | R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex |
| reactome | R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 |
| reactome | R-HSA-1538133 | G0 and Early G1 |
| reactome | R-HSA-1538133 | G0 and Early G1 |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-3700989 | Transcriptional Regulation by TP53 |
| reactome | R-HSA-453279 | Mitotic G1-G1/S phases |
| reactome | R-HSA-453279 | Mitotic G1-G1/S phases |
| reactome | R-HSA-539107 | Activation of E2F1 target genes at G1/S |
| reactome | R-HSA-539107 | Activation of E2F1 target genes at G1/S |
| reactome | R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes |
| reactome | R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest |
| reactome | R-HSA-69202 | Cyclin E associated events during G1/S transition |
| reactome | R-HSA-69205 | G1/S-Specific Transcription |
| reactome | R-HSA-69205 | G1/S-Specific Transcription |
| reactome | R-HSA-69206 | G1/S Transition |
| reactome | R-HSA-69206 | G1/S Transition |
| reactome | R-HSA-69231 | Cyclin D associated events in G1 |
| reactome | R-HSA-69236 | G1 Phase |
| reactome | R-HSA-69242 | S Phase |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| biocarta | etspathway | mets affect on macrophage differentiation |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD579 | PF750 | 2 |
| iGMDRD772 | BRD4770 | 2 |
| iGMDRD494 | Neopeltolide | 2 |
| iGMDRD446 | LY 2183240 | 2 |
| iGMDRD201 | SKI II | 2 |
| iGMDRD316 | N9-Isopropyl-olomoucine | 2 |
| iGMDRD351 | GW843682X | 2 |
| iGMDRD237 | ABT-751 | 3 |
| iGMDRD901 | ELCPK | 2 |
| iGMDRD123 | Isoevodiamine | 2 |
| iGMDRD466 | Chaetocin | 3 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD289 | Parthenolide | 3 |
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD213 | SMR000068650 | 2 |
| iGMDRD52 | Rotenone | 2 |
| iGMDRD100 | Zebularine | 3 |
| iGMDRD286 | Nsc 632839 | 2 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD74 | Idarubicin | 2 |
| iGMDRD888 | Compound 44 | 1 |
| iGMDRD398 | Sepantronium | 3 |
| iGMDRD366 | PI-103 | 6 |
| iGMDRD269 | Purmorphamine | 2 |
| iGMDRD246 | NPC26 | 2 |
| iGMDRD82 | Quiflapon | 2 |
| iGMDRD322 | FK 866 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RBL2
CLASSFICATION
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