RPL10
Summary: This gene encodes a ribosomal protein that is a component of the 60S ribosome subunit. The related protein in chicken can bind to c-Jun and can repress c-Jun-mediated transcriptional activation. Some studies have detected an association between variation in this gene and autism spectrum disorders, though others do not detect this relationship. There are multiple pseudogenes of this gene dispersed throughout the genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ribosomal protein L10 | MIM:312173 | Ensembl:ENSG00000147403 | HGNC:HGNC:10298 | PA34660 | Xq28 |
GO terms in RPL10
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005783 | endoplasmic reticulum |
| CC | IDA | GO:0005790 | smooth endoplasmic reticulum |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | HDA | GO:0016020 | membrane |
| CC | HDA | GO:0022625 | cytosolic large ribosomal subunit |
| CC | IBA | GO:0022625 | cytosolic large ribosomal subunit |
| CC | IDA | GO:0022625 | cytosolic large ribosomal subunit |
| CC | IDA | GO:0032991 | protein-containing complex |
| BP | IBA | GO:0000027 | ribosomal large subunit assembly |
| BP | IMP | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | TAS | GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
| BP | IC | GO:0006412 | translation |
| BP | NAS | GO:0006412 | translation |
| BP | TAS | GO:0006413 | translational initiation |
| BP | IMP | GO:0006417 | regulation of translation |
| BP | TAS | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane |
| BP | IMP | GO:0043066 | negative regulation of apoptotic process |
| BP | IMP | GO:1990403 | embryonic brain development |
| MF | HDA | GO:0003723 | RNA binding |
| MF | IBA | GO:0003735 | structural constituent of ribosome |
| MF | IDA | GO:0003735 | structural constituent of ribosome |
| MF | IMP | GO:0003735 | structural constituent of ribosome |
| MF | NAS | GO:0003735 | structural constituent of ribosome |
| MF | IPI | GO:0005515 | protein binding |
| MF | IMP | GO:0045182 | translation regulator activity |
Gene expression in normal tissue: RPL10
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RPL10
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa03010 | Ribosome - Homo sapiens (human) |
| wikipathways | WP477 | Cytoplasmic Ribosomal Proteins |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression |
| reactome | R-HSA-156842 | Eukaryotic Translation Elongation |
| reactome | R-HSA-156902 | Peptide chain elongation |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-168254 | Influenza Infection |
| reactome | R-HSA-168255 | Influenza Life Cycle |
| reactome | R-HSA-168273 | Influenza Viral RNA Transcription and Replication |
| reactome | R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane |
| reactome | R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane |
| reactome | R-HSA-192823 | Viral mRNA Translation |
| reactome | R-HSA-2408522 | Selenoamino acid metabolism |
| reactome | R-HSA-2408557 | Selenocysteine synthesis |
| reactome | R-HSA-376176 | Signaling by ROBO receptors |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-5663205 | Infectious disease |
| reactome | R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol |
| reactome | R-HSA-71291 | Metabolism of amino acids and derivatives |
| reactome | R-HSA-72312 | rRNA processing |
| reactome | R-HSA-72613 | Eukaryotic Translation Initiation |
| reactome | R-HSA-72689 | Formation of a pool of free 40S subunits |
| reactome | R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit |
| reactome | R-HSA-72737 | Cap-dependent Translation Initiation |
| reactome | R-HSA-72764 | Eukaryotic Translation Termination |
| reactome | R-HSA-72766 | Translation |
| reactome | R-HSA-72766 | Translation |
| reactome | R-HSA-8868773 | rRNA processing in the nucleus and cytosol |
| reactome | R-HSA-8953854 | Metabolism of RNA |
| reactome | R-HSA-9010553 | Regulation of expression of SLITs and ROBOs |
| reactome | R-HSA-927802 | Nonsense-Mediated Decay (NMD) |
| reactome | R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) |
| reactome | R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD772 | BRD4770 | 3 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD424 | Tamatinib | 1 |
| iGMDRD532 | Olaparib | 3 |
| iGMDRD730 | Kahalalide F | 3 |
| iGMDRD74 | Idarubicin | 3 |
| iGMDRD341 | Triacsin c | 3 |
| iGMDRD639 | YK 4-279 | 3 |
| iGMDRD444 | Tivantinib | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RPL10
CLASSFICATION
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