RPL10

Summary: This gene encodes a ribosomal protein that is a component of the 60S ribosome subunit. The related protein in chicken can bind to c-Jun and can repress c-Jun-mediated transcriptional activation. Some studies have detected an association between variation in this gene and autism spectrum disorders, though others do not detect this relationship. There are multiple pseudogenes of this gene dispersed throughout the genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Nameribosomal protein L10
OMIM IDMIM:312173
Ensembl IDEnsembl:ENSG00000147403
HGNC IDHGNC:HGNC:10298
PHARMGKB IDPA34660
Map LocationXq28

GO terms in RPL10


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Term Type
Evidence Type
GO Term ID
GO Des.
CC IDA GO:0005634 nucleus
CC IDA GO:0005783 endoplasmic reticulum
CC IDA GO:0005790 smooth endoplasmic reticulum
CC IDA GO:0005829 cytosol
CC TAS GO:0005829 cytosol
CC HDA GO:0016020 membrane
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Gene expression in normal tissue: RPL10

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 3undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 22

Gene-drug pathway distribution

undefined7RTK signaling1Genome integrity1

Pathways in RPL10


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Database
Pathway ID
Pathway Des.
kegg hsa03010 Ribosome - Homo sapiens (human)
wikipathways WP477 Cytoplasmic Ribosomal Proteins
reactome R-HSA-1266738 Developmental Biology
reactome R-HSA-1430728 Metabolism
reactome R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
reactome R-HSA-156842 Eukaryotic Translation Elongation
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD772 BRD4770 3
iGMDRD512 nutlin 3 3
iGMDRD424 Tamatinib 1
iGMDRD532 Olaparib 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RPL10

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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