TWF1
Summary: This gene encodes twinfilin, an actin monomer-binding protein conserved from yeast to mammals. Studies of the mouse counterpart suggest that this protein may be an actin monomer-binding protein, and its localization to cortical G-actin-rich structures may be regulated by the small GTPase RAC1. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| twinfilin actin binding protein 1 | MIM:610932 | Ensembl:ENSG00000151239 | HGNC:HGNC:9620 | PA162407406 | 12q12 |
GO terms in TWF1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | IBA | GO:0005884 | actin filament |
| CC | ISS | GO:0005911 | cell-cell junction |
| CC | HDA | GO:0005925 | focal adhesion |
| CC | ISS | GO:0015629 | actin cytoskeleton |
| CC | IBA | GO:0030016 | myofibril |
| CC | ISS | GO:0030016 | myofibril |
| CC | ISS | GO:0030175 | filopodium |
| CC | ISS | GO:0032587 | ruffle membrane |
| CC | ISS | GO:0048471 | perinuclear region of cytoplasm |
| BP | IBA | GO:0010591 | regulation of lamellipodium assembly |
| BP | IEA | GO:0010613 | positive regulation of cardiac muscle hypertrophy |
| BP | IBA | GO:0010976 | positive regulation of neuron projection development |
| BP | IBA | GO:0030042 | actin filament depolymerization |
| BP | ISS | GO:0030837 | negative regulation of actin filament polymerization |
| BP | IBA | GO:0042989 | sequestering of actin monomers |
| BP | ISS | GO:0042989 | sequestering of actin monomers |
| BP | IDA | GO:0043538 | regulation of actin phosphorylation |
| BP | IBA | GO:0051016 | barbed-end actin filament capping |
| BP | IEA | GO:0051016 | barbed-end actin filament capping |
| MF | IDA | GO:0003779 | actin binding |
| MF | IBA | GO:0003785 | actin monomer binding |
| MF | ISS | GO:0003785 | actin monomer binding |
| MF | IDA | GO:0004713 | protein tyrosine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0005524 | ATP binding |
| MF | ISS | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding |
| MF | IEA | GO:0044877 | protein-containing complex binding |
| MF | HDA | GO:0045296 | cadherin binding |
| MF | IBA | GO:0051015 | actin filament binding |
Gene expression in normal tissue: TWF1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TWF1
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD280 | CYTOCHALASIN B | 2 |
| iGMDRD466 | Chaetocin | 1 |
| iGMDRD61 | Kinetin riboside | 9 |
| iGMDRD237 | ABT-751 | 1 |
| iGMDRD316 | N9-Isopropyl-olomoucine | 1 |
| iGMDRD351 | GW843682X | 8 |
| iGMDRD201 | SKI II | 1 |
| iGMDRD446 | LY 2183240 | 1 |
| iGMDRD150 | RITA | 1 |
| iGMDRD772 | BRD4770 | 2 |
| iGMDRD579 | PF750 | 1 |
| iGMDRD889 | Compound 7d-cis | 2 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD322 | FK 866 | 2 |
| iGMDRD82 | Quiflapon | 1 |
| iGMDRD268 | Cerulenin | 1 |
| iGMDRD147 | Prima-1 | 1 |
| iGMDRD398 | Sepantronium | 2 |
| iGMDRD329 | Merck60 | 1 |
| iGMDRD74 | Idarubicin | 1 |
| iGMDRD188 | Piperlongumine | 1 |
| iGMDRD100 | Zebularine | 3 |
| iGMDRD213 | SMR000068650 | 1 |
| iGMDRD52 | Rotenone | 1 |
| iGMDRD121 | GMX1778 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TWF1
CLASSFICATION
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