CCDC6

Summary: This gene encodes a coiled-coil domain-containing protein. The encoded protein is ubiquitously expressed and may function as a tumor suppressor. A chromosomal rearrangement resulting in the expression of a fusion gene containing a portion of this gene and the intracellular kinase-encoding domain of the ret proto-oncogene is the cause of thyroid papillary carcinoma.[provided by RefSeq, Sep 2010].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namecoiled-coil domain containing 6
OMIM IDMIM:601985
Ensembl IDEnsembl:ENSG00000108091
HGNC IDHGNC:HGNC:18782
PHARMGKB IDPA134904022
Map Location10q21.2

GO terms in CCDC6


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IEA GO:0007010 cytoskeleton organization
BP ND GO:0008150 biological_process
CC IDA GO:0005829 cytosol
CC IEA GO:0005856 cytoskeleton
MF TAS GO:0005200 structural constituent of cytoskeleton
MF IPI GO:0005515 protein binding
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Gene expression in normal tissue: CCDC6

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 54BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 4

Gene-drug pathway distribution

undefined14Ferroptosis1Protein stability and degradation1ERK MAPK signaling1One carbon pool by folate1Stilbenoid, diarylheptanoid and gingerol biosynthesis1Apoptosis regulation1

Pathways in CCDC6


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Database
Pathway ID
Pathway Des.
wikipathways WP2446 Retinoblastoma (RB) in Cancer
wikipathways WP2857 Mesodermal Commitment Pathway
kegg hsa05200 Pathways in cancer - Homo sapiens (human)
kegg hsa05216 Thyroid cancer - Homo sapiens (human)
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD171 Pemetrexed 3
iGMDRD441 TW 37 3
iGMDRD202 Curcumin 6
iGMDRD271 Brefeldin A 1
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Gene in drug-gene network: Network Plot

XIAPXIAPMPLMPLHSPB8HSPB8TNK2TNK2TYMSTYMSWNK1WNK1TIE1TIE1RORARORARETRETSMG1SMG1DNAAF3DNAAF3AGERAGERWEE1WEE1XPCXPCPemetrexedPemetrexedMAP4K5MAP4K5ALS2ALS2HDLBPHDLBPBCKDKBCKDKEP300EP300KAT6BKAT6BRIPK2RIPK2ISG15ISG15MAP2K4MAP2K4ROS1ROS1FBN2FBN2MAP4K2MAP4K2MAPKBP1MAPKBP1DSTDSTFASNFASNDAPK1DAPK1CTNNB1CTNNB1TEX14TEX14TW 37TW 37UNC13CUNC13CCNTRLCNTRLCUBNCUBNIL1R1IL1R1PRKCGPRKCGEIF3AEIF3ACurcuminCurcuminSSU72SSU72TGTGADAMTSL3ADAMTSL3CHD6CHD6LPPLPPTCERG1LTCERG1LATRXATRXCXXC1CXXC1ARHGAP9ARHGAP9BRAFBRAFMAPK7MAPK7FLNBFLNBRB1RB1IGFBP5IGFBP5DGKGDGKGDOCK3DOCK3RELARELABrefeldin ABrefeldin AITGB6ITGB6TSHRTSHRTRPM7TRPM7NR2F1NR2F1AXIN2AXIN2SHC1SHC1MAP2K1MAP2K1TPRTPRPIK3CAPIK3CAEGFREGFRCSNK2A2CSNK2A2CBLCBLMEF2AMEF2AMYH11MYH11NUAK2NUAK2FRKFRKTyrphostin AG 1478Tyrphostin AG 1478TTKTTKNEK1NEK1HDAC2HDAC2CREBBPCREBBPC1DC1DOBSCNOBSCNEPHA3EPHA3BRIP1BRIP1ERBB4ERBB4CLTCL1CLTCL1SMAD4SMAD4IL17RDIL17RDCDH2CDH2NEK9NEK9TOP2ATOP2AKDM5AKDM5AParbendazoleParbendazoleITIH6ITIH6KRASKRASTRRAPTRRAPNLRP1NLRP1CDKN2ACDKN2ACDX2CDX2PIK3CBPIK3CBNRASNRASNF1NF1SelumetinibSelumetinibDHDDSDHDDSNKX2-1NKX2-1TENM1TENM1GUCY1A2GUCY1A2LNX2LNX2COL4A3BPCOL4A3BPPTCH1PTCH1HOXD13HOXD13BRD4BRD4PKN3PKN3GHRGHRTNFRSF4TNFRSF4Compound 23 citrateCompound 23 citrateKLK7KLK7MGAMGAUBR5UBR5GSK3AGSK3AMECOMMECOMIdarubicinIdarubicinCOPS5COPS5MALT1MALT1MYCLMYCLPRKXPRKXCDH11CDH11YAP1YAP1ROBO2ROBO2MFSD2AMFSD2APRAMEPRAMETGFB1TGFB1PiperlonguminePiperlongumineMYH9MYH9NUTM1NUTM1PCDH15PCDH15PAPPAPAPPATYK2TYK2DPYDDPYDCACNA1FCACNA1FLRP1BLRP1BHECW1HECW1NTRK3NTRK3ML 210ML 210PI4K2API4K2ASTK10STK10PRKDCPRKDCPNCKPNCKARHGDIBARHGDIBDYRK2DYRK2KNL1KNL1MMP8MMP8BIRC3BIRC3RUNX1T1RUNX1T1NeopeltolideNeopeltolideSIK2SIK2LTKLTKPOU2AF1POU2AF1ZFP69BZFP69BBRDTBRDTMSH3MSH3MAP2K3MAP2K3LATS2LATS2YWHAQYWHAQADAMTS2ADAMTS2PRKD1PRKD1DHFRDHFRTMPOTMPOJAK1JAK1PF750PF750ADAMTS20ADAMTS20IKZF3IKZF3STK40STK40PIP5K1BPIP5K1BCMC4CMC4RPTORRPTORPHKG1PHKG1GRIA3GRIA3CYTOCHALASIN BCYTOCHALASIN BKCNH2KCNH2PDCD1PDCD1PHIPPHIPTPH1TPH1CTNNA2CTNNA2FOXP1FOXP1PAX3PAX3LRGUKLRGUKLRRK2LRRK2PEAK1PEAK1WASWASIsoevodiamineIsoevodiamineFBN1FBN1NANOS3NANOS3CCDC50CCDC50CNTN5CNTN5GMPSGMPSTAF1TAF1CLTCCLTCNKD2NKD2ITPR2ITPR2PALB2PALB2(1S,3R)-RSL3(1S,3R)-RSL3Sparfosic acidSparfosic acidMSH6MSH6LRP2LRP2COL14A1COL14A1SIK3SIK3CACNB2CACNB2SOS1SOS1ALPK2ALPK2GRK7GRK7JAG1JAG1LY 2183240LY 2183240NYNRINNYNRINMAP3K1MAP3K1NCAM1NCAM1Fqi1Fqi1DLC1DLC1KCTD14KCTD14MKRN3MKRN3SKILSKILHNRNPA2B1HNRNPA2B1TanespimycinTanespimycinCCDC6CCDC6

Gene-drug targets distribution

Gene Structure: PDB

Models in CCDC6

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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