GO terms in PMAIP1


Term TypeEvidence TypeGO Term IDGO Des.
CCIDAGO:0005634nucleus
CCIBAGO:0005739mitochondrion
CCIDAGO:0005739mitochondrion
CCTASGO:0005741mitochondrial outer membrane
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
BPIEAGO:0001836release of cytochrome c from mitochondria
BPTASGO:0001844protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
BPIMPGO:0006915apoptotic process
BPIEAGO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process
BPIEAGO:0006974cellular response to DNA damage stimulus
BPIDAGO:0010498proteasomal protein catabolic process
BPIDAGO:0010907positive regulation of glucose metabolic process
BPISSGO:0010917negative regulation of mitochondrial membrane potential
BPIDAGO:0032461positive regulation of protein oligomerization
BPIMPGO:0042149cellular response to glucose starvation
BPTASGO:0042981regulation of apoptotic process
BPISSGO:0043029T cell homeostasis
BPIDAGO:0043065positive regulation of apoptotic process
BPIMPGO:0043065positive regulation of apoptotic process
BPIDAGO:0043280positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
BPIDAGO:0043331response to dsRNA
BPIMPGO:0043517positive regulation of DNA damage response, signal transduction by p53 class mediator
BPIDAGO:0046902regulation of mitochondrial membrane permeability
BPIDAGO:0051607defense response to virus
BPIEPGO:0071456cellular response to hypoxia
BPIMPGO:0072332intrinsic apoptotic signaling pathway by p53 class mediator
BPIDAGO:0072593reactive oxygen species metabolic process
BPIDAGO:0090200positive regulation of release of cytochrome c from mitochondria
BPIMPGO:0090200positive regulation of release of cytochrome c from mitochondria
BPIDAGO:0097193intrinsic apoptotic signaling pathway
BPTASGO:1900740positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
BPIDAGO:1902043positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
BPTASGO:1902237positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
BPIDAGO:2001244positive regulation of intrinsic apoptotic signaling pathway
BPTASGO:2001244positive regulation of intrinsic apoptotic signaling pathway
MFIPIGO:0005515protein binding

Gene expression in normal tissue: PMAIP1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PMAIP1


DatabasePathway IDPathway Des.
pidmyc_activpathwayValidated targets of C-MYC transcriptional activation
pidp53downstreampathwayDirect p53 effectors
pidtap63pathwayValidated transcriptional targets of TAp63 isoforms
kegghsa04115p53 signaling pathway - Homo sapiens (human)
kegghsa04210Apoptosis - Homo sapiens (human)
kegghsa04215Apoptosis - multiple species - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05203Viral carcinogenesis - Homo sapiens (human)
kegghsa05210Colorectal cancer - Homo sapiens (human)
wikipathwaysWP1530miRNA Regulation of DNA Damage Response
wikipathwaysWP1742TP53 Network
wikipathwaysWP1772Apoptosis Modulation and Signaling
wikipathwaysWP1841Intrinsic Pathway for Apoptosis
wikipathwaysWP254Apoptosis
wikipathwaysWP3614Photodynamic therapy-induced HIF-1 survival signaling
wikipathwaysWP3639Apoptotic Signaling Pathway
wikipathwaysWP3802TP53 Regulates Transcription of Cell Death Genes
wikipathwaysWP3969H19 action Rb-E2F1 signaling and CDK-?-catenin activity
wikipathwaysWP3982miRNA regulation of p53 pathway in prostate cancer
wikipathwaysWP4216Chromosomal and microsatellite instability in colorectal cancer
wikipathwaysWP707DNA Damage Response
wikipathwaysWP710DNA Damage Response (only ATM dependent)
reactomeR-HSA-109581Apoptosis
reactomeR-HSA-109606Intrinsic Pathway for Apoptosis
reactomeR-HSA-111448Activation of NOXA and translocation to mitochondria
reactomeR-HSA-111453BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
reactomeR-HSA-114452Activation of BH3-only proteins
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-3700989Transcriptional Regulation by TP53
reactomeR-HSA-5357801Programmed Cell Death
reactomeR-HSA-5633008TP53 Regulates Transcription of Cell Death Genes
reactomeR-HSA-6803204TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD6AM-5803
iGMDRD171Pemetrexed3
iGMDRD8012,4-dideoxy-DC-45-A23
iGMDRD213SMR0000686503
iGMDRD294Batimastat3
iGMDRD137Indisulam1
iGMDRD220fumonisin B13
iGMDRD5Tyrphostin AG 14781
iGMDRD690PRIMA-1MET3
iGMDRD147Prima-11
iGMDRD451Serdemetan3
iGMDRD871BRD63683
iGMDRD74Idarubicin3
iGMDRD329Merck603
iGMDRD577BIX012943
iGMDRD780PP-303
iGMDRD532Olaparib3
iGMDRD781Sirolimus3
iGMDRD48Dexamethasone3
iGMDRD126Tipifarnib3
iGMDRD307Manumycin A1
iGMDRD889Compound 7d-cis3
iGMDRD607Ubistatin B3
iGMDRD512nutlin 33
iGMDRD425ERASTIN3
iGMDRD772BRD47703
iGMDRD280CYTOCHALASIN B3
iGMDRD132(-)-gallocatechin-3-O-gallate1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PMAIP1

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