TSSK6
Summary: This intronless gene encodes a member of the CAMK (calcium/calmodulin-dependent) serine/threonine protein kinase family. The encoded kinase has a broad expression pattern but is described as testis-specific due to effects on fertility. Male mice which lack the gene encoding a highly similar protein are sterile and have morphologically abnormal sperm. [provided by RefSeq, Jan 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| testis specific serine kinase 6 | MIM:610712 | Ensembl:ENSG00000178093 | HGNC:HGNC:30410 | PA142670682 | 19p13.11 |
GO terms in TSSK6
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0000287 | magnesium ion binding |
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0005524 | ATP binding |
| BP | IBA | GO:0006468 | protein phosphorylation |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | IEA | GO:0007275 | multicellular organism development |
| BP | ISS | GO:0035092 | sperm chromatin condensation |
| BP | IBA | GO:0035556 | intracellular signal transduction |
| CC | HDA | GO:0005634 | nucleus |
| CC | IBA | GO:0005634 | nucleus |
| CC | IBA | GO:0005737 | cytoplasm |
Gene expression in normal tissue: TSSK6
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TSSK6
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD177 | Teniposide | 1 |
| iGMDRD154 | NSC23766 | 6 |
| iGMDRD314 | Tanespimycin | 2 |
| iGMDRD48 | Dexamethasone | 2 |
| iGMDRD307 | Manumycin A | 2 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD584 | VER 155008 | 2 |
| iGMDRD505 | Pevonedistat | 3 |
| iGMDRD300 | Tozasertib | 1 |
| iGMDRD286 | Nsc 632839 | 2 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD6 | AM-580 | 2 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD158 | NSC141540 | 3 |
| iGMDRD137 | Indisulam | 1 |
| iGMDRD375 | GW-405833 | 3 |
| iGMDRD61 | Kinetin riboside | 3 |
| iGMDRD193 | Fqi1 | 2 |
| iGMDRD144 | NSC95397 | 2 |
| iGMDRD427 | ABT737 | 3 |
| iGMDRD126 | Tipifarnib | 2 |
| iGMDRD579 | PF750 | 2 |
| iGMDRD23 | Gossypol | 2 |
| iGMDRD524 | ISX-9 | 3 |
| iGMDRD451 | Serdemetan | 3 |
| iGMDRD188 | Piperlongumine | 5 |
| iGMDRD74 | Idarubicin | 2 |
| iGMDRD506 | Fedratinib | 1 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD171 | Pemetrexed | 1 |
| iGMDRD782 | DC-45-A2 | 3 |
| iGMDRD187 | BRD9876 | 3 |
| iGMDRD270 | Ciclosporin | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TSSK6
CLASSFICATION
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