PICALM


Summary: This gene encodes a clathrin assembly protein, which recruits clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. The protein may be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. The protein is involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction. A chromosomal translocation t(10;11)(p13;q14) leading to the fusion of this gene and the MLLT10 gene is found in acute lymphoblastic leukemia, acute myeloid leukemia and malignant lymphomas. The polymorphisms of this gene are associated with the risk of Alzheimer disease. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
phosphatidylinositol binding clathrin assembly proteinMIM:603025Ensembl:ENSG00000073921HGNC:HGNC:15514PA3328711q14.2

GO terms in PICALM


Term TypeEvidence TypeGO Term IDGO Des.
BPIDAGO:0006898receptor-mediated endocytosis
BPISSGO:0006898receptor-mediated endocytosis
BPIEAGO:0007409axonogenesis
BPISSGO:0007611learning or memory
BPIMPGO:0008283cell proliferation
BPIMPGO:0010629negative regulation of gene expression
BPIMPGO:0016050vesicle organization
BPISSGO:0016188synaptic vesicle maturation
BPTASGO:0016192vesicle-mediated transport
BPIMPGO:0016197endosomal transport
BPIEAGO:0030097hemopoiesis
BPIMPGO:0030100regulation of endocytosis
BPIMPGO:0031623receptor internalization
BPIDAGO:0032880regulation of protein localization
BPIMPGO:0035459cargo loading into vesicle
BPIMPGO:0043547positive regulation of GTPase activity
BPIMPGO:0045056transcytosis
BPIDAGO:0045893positive regulation of transcription, DNA-templated
BPIDAGO:0048261negative regulation of receptor-mediated endocytosis
BPIMPGO:0048268clathrin coat assembly
BPIEAGO:0048813dendrite morphogenesis
BPIMPGO:0055072iron ion homeostasis
BPTASGO:0061024membrane organization
BPTASGO:0065003protein-containing complex assembly
BPIMPGO:0072583clathrin-dependent endocytosis
BPISSGO:0090647modulation of age-related behavioral decline
BPIMPGO:0097494regulation of vesicle size
BPIMPGO:0097753membrane bending
BPIMPGO:0098711iron ion import across plasma membrane
BPISSGO:1900223positive regulation of amyloid-beta clearance
BPIMPGO:1901216positive regulation of neuron death
BPISSGO:1902003regulation of amyloid-beta formation
BPIMPGO:1902004positive regulation of amyloid-beta formation
BPTASGO:1902004positive regulation of amyloid-beta formation
BPIMPGO:1902959regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
BPISSGO:1902961positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
BPISSGO:1902963negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process
BPIMPGO:1903077negative regulation of protein localization to plasma membrane
BPIMPGO:2000009negative regulation of protein localization to cell surface
BPNASGO:2000370positive regulation of clathrin-dependent endocytosis
CCIDAGO:0005634nucleus
CCIDAGO:0005769early endosome
CCIEAGO:0005794Golgi apparatus
CCTASGO:0005829cytosol
CCIDAGO:0005905clathrin-coated pit
CCIMPGO:0005905clathrin-coated pit
CCISSGO:0005905clathrin-coated pit
CCIDAGO:0009986cell surface
CCHDAGO:0016020membrane
CCIDAGO:0030122AP-2 adaptor complex
CCIDAGO:0030132clathrin coat of coated pit
CCIMPGO:0030136clathrin-coated vesicle
CCISSGO:0031224intrinsic component of membrane
CCISSGO:0031982vesicle
CCISSGO:0042734presynaptic membrane
CCIDAGO:0043025neuronal cell body
CCIDAGO:0043231intracellular membrane-bounded organelle
CCISSGO:0045211postsynaptic membrane
CCNASGO:0045334clathrin-coated endocytic vesicle
CCISSGO:0048471perinuclear region of cytoplasm
CCIDAGO:0070381endosome to plasma membrane transport vesicle
CCIMPGO:0097418neurofibrillary tangle
MFIPIGO:0005515protein binding
MFISSGO:00055451-phosphatidylinositol binding
MFISSGO:0005546phosphatidylinositol-4,5-bisphosphate binding
MFIPIGO:0017137Rab GTPase binding
MFIDAGO:0030276clathrin binding
MFIPIGO:0030276clathrin binding
MFISSGO:0030276clathrin binding
MFIDAGO:0032050clathrin heavy chain binding
MFIMPGO:0035615clathrin adaptor activity
MFHDAGO:0045296cadherin binding
MFIPIGO:0050750low-density lipoprotein particle receptor binding

Gene expression in normal tissue: PICALM

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PICALM


DatabasePathway IDPathway Des.
wikipathwaysWP2001miR-targeted genes in adipocytes - TarBase
wikipathwaysWP2002miR-targeted genes in epithelium - TarBase
wikipathwaysWP2004miR-targeted genes in lymphocytes - TarBase
wikipathwaysWP2005miR-targeted genes in muscle cell - TarBase
wikipathwaysWP2006miR-targeted genes in squamous cell - TarBase
biocartandkdynaminpathwayendocytotic role of ndk phosphins and dynamin
reactomeR-HSA-199991Membrane Trafficking
reactomeR-HSA-199992trans-Golgi Network Vesicle Budding
reactomeR-HSA-421837Clathrin derived vesicle budding
reactomeR-HSA-432722Golgi Associated Vesicle Biogenesis
reactomeR-HSA-5653656Vesicle-mediated transport
reactomeR-HSA-8856825Cargo recognition for clathrin-mediated endocytosis
reactomeR-HSA-8856828Clathrin-mediated endocytosis

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD1008SR-II-138A3
iGMDRD307Manumycin A3
iGMDRD554CHEMBL14341373
iGMDRD144NSC953976
iGMDRD532Olaparib3
iGMDRD193Fqi13
iGMDRD446LY 21832403
iGMDRD945ML2143
iGMDRD883CIL55A3
iGMDRD123Isoevodiamine3
iGMDRD280CYTOCHALASIN B3
iGMDRD138PX 123
iGMDRD251ML1623
iGMDRD158NSC1415403
iGMDRD121GMX17786
iGMDRD513BML-2593
iGMDRD870BRD636103
iGMDRD415LE-1353
iGMDRD318PAC-13
iGMDRD434BMS-5369241
iGMDRD705Nakiterpiosin3
iGMDRD105Triptolide2
iGMDRD289Parthenolide3
iGMDRD577BIX012946
iGMDRD74Idarubicin3
iGMDRD188Piperlongumine6
iGMDRD286Nsc 6328393
iGMDRD322FK 8666
iGMDRD82Quiflapon3
iGMDRD64Parbendazole3
iGMDRD246NPC263

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PICALM

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