PICALM
Summary: This gene encodes a clathrin assembly protein, which recruits clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. The protein may be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. The protein is involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction. A chromosomal translocation t(10;11)(p13;q14) leading to the fusion of this gene and the MLLT10 gene is found in acute lymphoblastic leukemia, acute myeloid leukemia and malignant lymphomas. The polymorphisms of this gene are associated with the risk of Alzheimer disease. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| phosphatidylinositol binding clathrin assembly protein | MIM:603025 | Ensembl:ENSG00000073921 | HGNC:HGNC:15514 | PA33287 | 11q14.2 |
GO terms in PICALM
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IDA | GO:0006898 | receptor-mediated endocytosis |
| BP | ISS | GO:0006898 | receptor-mediated endocytosis |
| BP | IEA | GO:0007409 | axonogenesis |
| BP | ISS | GO:0007611 | learning or memory |
| BP | IMP | GO:0008283 | cell proliferation |
| BP | IMP | GO:0010629 | negative regulation of gene expression |
| BP | IMP | GO:0016050 | vesicle organization |
| BP | ISS | GO:0016188 | synaptic vesicle maturation |
| BP | TAS | GO:0016192 | vesicle-mediated transport |
| BP | IMP | GO:0016197 | endosomal transport |
| BP | IEA | GO:0030097 | hemopoiesis |
| BP | IMP | GO:0030100 | regulation of endocytosis |
| BP | IMP | GO:0031623 | receptor internalization |
| BP | IDA | GO:0032880 | regulation of protein localization |
| BP | IMP | GO:0035459 | cargo loading into vesicle |
| BP | IMP | GO:0043547 | positive regulation of GTPase activity |
| BP | IMP | GO:0045056 | transcytosis |
| BP | IDA | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IDA | GO:0048261 | negative regulation of receptor-mediated endocytosis |
| BP | IMP | GO:0048268 | clathrin coat assembly |
| BP | IEA | GO:0048813 | dendrite morphogenesis |
| BP | IMP | GO:0055072 | iron ion homeostasis |
| BP | TAS | GO:0061024 | membrane organization |
| BP | TAS | GO:0065003 | protein-containing complex assembly |
| BP | IMP | GO:0072583 | clathrin-dependent endocytosis |
| BP | ISS | GO:0090647 | modulation of age-related behavioral decline |
| BP | IMP | GO:0097494 | regulation of vesicle size |
| BP | IMP | GO:0097753 | membrane bending |
| BP | IMP | GO:0098711 | iron ion import across plasma membrane |
| BP | ISS | GO:1900223 | positive regulation of amyloid-beta clearance |
| BP | IMP | GO:1901216 | positive regulation of neuron death |
| BP | ISS | GO:1902003 | regulation of amyloid-beta formation |
| BP | IMP | GO:1902004 | positive regulation of amyloid-beta formation |
| BP | TAS | GO:1902004 | positive regulation of amyloid-beta formation |
| BP | IMP | GO:1902959 | regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process |
| BP | ISS | GO:1902961 | positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process |
| BP | ISS | GO:1902963 | negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process |
| BP | IMP | GO:1903077 | negative regulation of protein localization to plasma membrane |
| BP | IMP | GO:2000009 | negative regulation of protein localization to cell surface |
| BP | NAS | GO:2000370 | positive regulation of clathrin-dependent endocytosis |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005769 | early endosome |
| CC | IEA | GO:0005794 | Golgi apparatus |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0005905 | clathrin-coated pit |
| CC | IMP | GO:0005905 | clathrin-coated pit |
| CC | ISS | GO:0005905 | clathrin-coated pit |
| CC | IDA | GO:0009986 | cell surface |
| CC | HDA | GO:0016020 | membrane |
| CC | IDA | GO:0030122 | AP-2 adaptor complex |
| CC | IDA | GO:0030132 | clathrin coat of coated pit |
| CC | IMP | GO:0030136 | clathrin-coated vesicle |
| CC | ISS | GO:0031224 | intrinsic component of membrane |
| CC | ISS | GO:0031982 | vesicle |
| CC | ISS | GO:0042734 | presynaptic membrane |
| CC | IDA | GO:0043025 | neuronal cell body |
| CC | IDA | GO:0043231 | intracellular membrane-bounded organelle |
| CC | ISS | GO:0045211 | postsynaptic membrane |
| CC | NAS | GO:0045334 | clathrin-coated endocytic vesicle |
| CC | ISS | GO:0048471 | perinuclear region of cytoplasm |
| CC | IDA | GO:0070381 | endosome to plasma membrane transport vesicle |
| CC | IMP | GO:0097418 | neurofibrillary tangle |
| MF | IPI | GO:0005515 | protein binding |
| MF | ISS | GO:0005545 | 1-phosphatidylinositol binding |
| MF | ISS | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding |
| MF | IPI | GO:0017137 | Rab GTPase binding |
| MF | IDA | GO:0030276 | clathrin binding |
| MF | IPI | GO:0030276 | clathrin binding |
| MF | ISS | GO:0030276 | clathrin binding |
| MF | IDA | GO:0032050 | clathrin heavy chain binding |
| MF | IMP | GO:0035615 | clathrin adaptor activity |
| MF | HDA | GO:0045296 | cadherin binding |
| MF | IPI | GO:0050750 | low-density lipoprotein particle receptor binding |
Gene expression in normal tissue: PICALM
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PICALM
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2001 | miR-targeted genes in adipocytes - TarBase |
| wikipathways | WP2002 | miR-targeted genes in epithelium - TarBase |
| wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
| wikipathways | WP2005 | miR-targeted genes in muscle cell - TarBase |
| wikipathways | WP2006 | miR-targeted genes in squamous cell - TarBase |
| biocarta | ndkdynaminpathway | endocytotic role of ndk phosphins and dynamin |
| reactome | R-HSA-199991 | Membrane Trafficking |
| reactome | R-HSA-199992 | trans-Golgi Network Vesicle Budding |
| reactome | R-HSA-421837 | Clathrin derived vesicle budding |
| reactome | R-HSA-432722 | Golgi Associated Vesicle Biogenesis |
| reactome | R-HSA-5653656 | Vesicle-mediated transport |
| reactome | R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis |
| reactome | R-HSA-8856828 | Clathrin-mediated endocytosis |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD1008 | SR-II-138A | 3 |
| iGMDRD307 | Manumycin A | 3 |
| iGMDRD554 | CHEMBL1434137 | 3 |
| iGMDRD144 | NSC95397 | 6 |
| iGMDRD532 | Olaparib | 3 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD945 | ML214 | 3 |
| iGMDRD883 | CIL55A | 3 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD138 | PX 12 | 3 |
| iGMDRD251 | ML162 | 3 |
| iGMDRD158 | NSC141540 | 3 |
| iGMDRD121 | GMX1778 | 6 |
| iGMDRD513 | BML-259 | 3 |
| iGMDRD870 | BRD63610 | 3 |
| iGMDRD415 | LE-135 | 3 |
| iGMDRD318 | PAC-1 | 3 |
| iGMDRD434 | BMS-536924 | 1 |
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD105 | Triptolide | 2 |
| iGMDRD289 | Parthenolide | 3 |
| iGMDRD577 | BIX01294 | 6 |
| iGMDRD74 | Idarubicin | 3 |
| iGMDRD188 | Piperlongumine | 6 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD322 | FK 866 | 6 |
| iGMDRD82 | Quiflapon | 3 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD246 | NPC26 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PICALM
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.