TELO2
Summary: This gene encodes a protein that functions as an S-phase checkpoint protein in the cell cycle. The protein may also play a role in DNA repair.[provided by RefSeq, Mar 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| telomere maintenance 2 | MIM:611140 | Ensembl:ENSG00000100726 | HGNC:HGNC:29099 | PA162405604 | 16p13.3 |
GO terms in TELO2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IEA | GO:0000781 | chromosome, telomeric region |
| CC | IBA | GO:0000784 | nuclear chromosome, telomeric region |
| CC | IDA | GO:0005622 | intracellular |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IBA | GO:0005829 | cytosol |
| CC | IDA | GO:0005829 | cytosol |
| CC | IEA | GO:0016020 | membrane |
| CC | IDA | GO:0016604 | nuclear body |
| CC | IDA | GO:0031931 | TORC1 complex |
| CC | IDA | GO:0031932 | TORC2 complex |
| CC | IDA | GO:0034399 | nuclear periphery |
| CC | IBA | GO:0070209 | ASTRA complex |
| BP | IBA | GO:0000723 | telomere maintenance |
| BP | IMP | GO:0032006 | regulation of TOR signaling |
| BP | IMP | GO:0050821 | protein stabilization |
| BP | IMP | GO:0071902 | positive regulation of protein serine/threonine kinase activity |
| BP | IMP | GO:1904263 | positive regulation of TORC1 signaling |
| BP | IMP | GO:1904515 | positive regulation of TORC2 signaling |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0019901 | protein kinase binding |
| MF | IEA | GO:0032947 | protein-containing complex scaffold activity |
| MF | IBA | GO:0042162 | telomeric DNA binding |
| MF | IDA | GO:0044877 | protein-containing complex binding |
| MF | IPI | GO:0051879 | Hsp90 protein binding |
Gene expression in normal tissue: TELO2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TELO2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa03460 | Fanconi anemia pathway - Homo sapiens (human) |
| kegg | hsa04150 | mTOR signaling pathway - Homo sapiens (human) |
| wikipathways | WP4011 | Steatosis AOP |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD772 | BRD4770 | 3 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD409 | Saracatinib | 1 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 1 |
| iGMDRD154 | NSC23766 | 6 |
| iGMDRD123 | Isoevodiamine | 1 |
| iGMDRD466 | Chaetocin | 3 |
| iGMDRD211 | (1S,3R)-RSL3 | 3 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD138 | PX 12 | 3 |
| iGMDRD289 | Parthenolide | 3 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD506 | Fedratinib | 6 |
| iGMDRD74 | Idarubicin | 3 |
| iGMDRD268 | Cerulenin | 3 |
| iGMDRD42 | Vorinostat | 3 |
| iGMDRD64 | Parbendazole | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TELO2
CLASSFICATION
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