SCD5
Summary: Stearoyl-CoA desaturase (SCD; EC 1.14.99.5) is an integral membrane protein of the endoplasmic reticulum that catalyzes the formation of monounsaturated fatty acids from saturated fatty acids. SCD may be a key regulator of energy metabolism with a role in obesity and dislipidemia. Four SCD isoforms, Scd1 through Scd4, have been identified in mouse. In contrast, only 2 SCD isoforms, SCD1 (MIM 604031) and SCD5, have been identified in human. SCD1 shares about 85% amino acid identity with all 4 mouse SCD isoforms, as well as with rat Scd1 and Scd2. In contrast, SCD5 shares limited homology with the rodent SCDs and appears to be unique to primates (Wang et al., 2005 [PubMed 15907797]).[supplied by OMIM, Mar 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| stearoyl-CoA desaturase 5 | MIM:608370 | Ensembl:ENSG00000145284 | HGNC:HGNC:21088 | PA134934692 | 4q21.22 |
Gene Categories:
DRUGGABLE GENOMEGO terms in SCD5
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IDA | GO:0006636 | unsaturated fatty acid biosynthetic process |
| BP | TAS | GO:0046949 | fatty-acyl-CoA biosynthetic process |
| BP | IEA | GO:0055114 | oxidation-reduction process |
| BP | IBA | GO:1903966 | monounsaturated fatty acid biosynthetic process |
| CC | IBA | GO:0005789 | endoplasmic reticulum membrane |
| CC | IDA | GO:0005789 | endoplasmic reticulum membrane |
| CC | TAS | GO:0005789 | endoplasmic reticulum membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| MF | EXP | GO:0004768 | stearoyl-CoA 9-desaturase activity |
| MF | IBA | GO:0004768 | stearoyl-CoA 9-desaturase activity |
| MF | IDA | GO:0004768 | stearoyl-CoA 9-desaturase activity |
| MF | IBA | GO:0005506 | iron ion binding |
| MF | IDA | GO:0016491 | oxidoreductase activity |
| MF | IEA | GO:0046872 | metal ion binding |
Gene expression in normal tissue: SCD5
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SCD5
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-556833 | Metabolism of lipids |
| reactome | R-HSA-75105 | Fatty acyl-CoA biosynthesis |
| reactome | R-HSA-8978868 | Fatty acid metabolism |
| kegg | hsa01040 | Biosynthesis of unsaturated fatty acids - Homo sapiens (human) |
| kegg | hsa03320 | PPAR signaling pathway - Homo sapiens (human) |
| kegg | hsa04152 | AMPK signaling pathway - Homo sapiens (human) |
| humancyc | PWY-5996 | oleate biosynthesis |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD451 | Serdemetan | 3 |
| iGMDRD74 | Idarubicin | 2 |
| iGMDRD562 | Navitoclax | 6 |
| iGMDRD171 | Pemetrexed | 1 |
| iGMDRD294 | Batimastat | 3 |
| iGMDRD187 | BRD9876 | 2 |
| iGMDRD801 | 2,4-dideoxy-DC-45-A2 | 2 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD158 | NSC141540 | 3 |
| iGMDRD802 | 4-methylfasudil | 3 |
| iGMDRD177 | Teniposide | 1 |
| iGMDRD154 | NSC23766 | 6 |
| iGMDRD375 | GW-405833 | 3 |
| iGMDRD314 | Tanespimycin | 2 |
| iGMDRD427 | ABT737 | 6 |
| iGMDRD512 | nutlin 3 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SCD5
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