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TXK

Summary:

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
TXK tyrosine kinase	MIM:600058	Ensembl:ENSG00000074966	HGNC:HGNC:12434	PA37090	4p12

Gene Categories:

KINASE PHOSPHOLIPASE TYROSINE KINASE DRUGGABLE GENOME

GO terms in TXK

Term Type	Evidence Type	GO Term ID	GO Des.
BP	ISS	GO:0001816	cytokine production
BP	IBA	GO:0002250	adaptive immune response
BP	ISS	GO:0002250	adaptive immune response
BP	IDA	GO:0006357	regulation of transcription by RNA polymerase II
BP	IEA	GO:0006366	transcription by RNA polymerase II
BP	IDA	GO:0006468	protein phosphorylation
BP	IBA	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
BP	ISS	GO:0007202	activation of phospholipase C activity
BP	IBA	GO:0030154	cell differentiation
BP	IBA	GO:0030217	T cell differentiation
BP	IDA	GO:0032729	positive regulation of interferon-gamma production
BP	IBA	GO:0038083	peptidyl-tyrosine autophosphorylation
BP	IBA	GO:0042127	regulation of cell proliferation
BP	IBA	GO:0045087	innate immune response
BP	IDA	GO:0045944	positive regulation of transcription by RNA polymerase II
BP	IDA	GO:0046777	protein autophosphorylation
BP	IBA	GO:0050852	T cell receptor signaling pathway
BP	ISS	GO:0050852	T cell receptor signaling pathway
BP	IBA	GO:0050853	B cell receptor signaling pathway
BP	IDA	GO:0060335	positive regulation of interferon-gamma-mediated signaling pathway
CC	IDA	GO:0005634	nucleus
CC	IDA	GO:0005737	cytoplasm
CC	IBA	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
MF	IDA	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding
MF	IDA	GO:0001012	RNA polymerase II regulatory region DNA binding
MF	IDA	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MF	IBA	GO:0004715	non-membrane spanning protein tyrosine kinase activity
MF	IBA	GO:0005102	signaling receptor binding
MF	IPI	GO:0005515	protein binding
MF	IEA	GO:0005524	ATP binding

Gene expression in normal tissue: TXK

Select Project:

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TXK

Database	Pathway ID	Pathway Des.
reactome	R-HSA-168249	Innate Immune System
reactome	R-HSA-168249	Innate Immune System
reactome	R-HSA-168256	Immune System
reactome	R-HSA-168256	Immune System
reactome	R-HSA-2454202	Fc epsilon receptor (FCERI) signaling
reactome	R-HSA-2454202	Fc epsilon receptor (FCERI) signaling
reactome	R-HSA-2871809	FCERI mediated Ca+2 mobilization
reactome	R-HSA-2871809	FCERI mediated Ca+2 mobilization
netpath	Pathway_TCR	TCR
kegg	hsa04670	Leukocyte transendothelial migration - Homo sapiens (human)
wikipathways	WP306	Focal Adhesion

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD872	BRD7137	4
iGMDRD414	MST-312	2
iGMDRD329	Merck60	4
iGMDRD322	FK 866	2
iGMDRD158	NSC141540	5
iGMDRD137	Indisulam	1
iGMDRD705	Nakiterpiosin	1
iGMDRD231	Importazole	3
iGMDRD341	Triacsin c	2
iGMDRD314	Tanespimycin	3
iGMDRD177	Teniposide	2
iGMDRD154	NSC23766	4
iGMDRD307	Manumycin A	3
iGMDRD512	nutlin 3	2
iGMDRD560	MK-2206	3
iGMDRD405	PIK-75	4
iGMDRD399	Selumetinib	2
iGMDRD74	Idarubicin	3
iGMDRD60	Quinoclamine	2
iGMDRD640	CAY10618	3
iGMDRD690	PRIMA-1MET	3
iGMDRD451	Serdemetan	2
iGMDRD255	SB225002	3
iGMDRD294	Batimastat	2
iGMDRD187	BRD9876	2
iGMDRD801	2,4-dideoxy-DC-45-A2	2
iGMDRD61	Kinetin riboside	3
iGMDRD679	Bistramide A	1
iGMDRD297	Austocystin D	2
iGMDRD375	GW-405833	2
iGMDRD1008	SR-II-138A	1
iGMDRD229	B02	3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TXK

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.