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DAPK1

Summary: Death-associated protein kinase 1 is a positive mediator of gamma-interferon induced programmed cell death. DAPK1 encodes a structurally unique 160-kD calmodulin dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites. It is a tumor suppressor candidate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
death associated protein kinase 1	MIM:600831	Ensembl:ENSG00000196730	HGNC:HGNC:2674	PA27142	9q21.33

Gene Categories:

ION CHANNEL PROTEASE SERINE THREONINE KINASE KINASE TRANSPORTER DRUGGABLE GENOME

GO terms in DAPK1

Term Type	Evidence Type	GO Term ID	GO Des.
BP	IDA	GO:0006468	protein phosphorylation
BP	TAS	GO:0006468	protein phosphorylation
BP	IGI	GO:0006915	apoptotic process
BP	IMP	GO:0006915	apoptotic process
BP	IEA	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors
BP	TAS	GO:0010506	regulation of autophagy
BP	IMP	GO:0010508	positive regulation of autophagy
BP	IDA	GO:0017148	negative regulation of translation
BP	IDA	GO:0035556	intracellular signal transduction
BP	TAS	GO:0042981	regulation of apoptotic process
BP	IDA	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
BP	IDA	GO:0046777	protein autophosphorylation
BP	TAS	GO:0046777	protein autophosphorylation
BP	IDA	GO:0071346	cellular response to interferon-gamma
BP	IMP	GO:0071447	cellular response to hydroperoxide
BP	IMP	GO:0097190	apoptotic signaling pathway
BP	IEA	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
BP	ISS	GO:2000310	regulation of NMDA receptor activity
CC	IBA	GO:0005634	nucleus
CC	IDA	GO:0005737	cytoplasm
CC	IDA	GO:0005886	plasma membrane
CC	IDA	GO:0015629	actin cytoskeleton
MF	IDA	GO:0004672	protein kinase activity
MF	IBA	GO:0004674	protein serine/threonine kinase activity
MF	TAS	GO:0004674	protein serine/threonine kinase activity
MF	IDA	GO:0004683	calmodulin-dependent protein kinase activity
MF	IPI	GO:0005515	protein binding
MF	IDA	GO:0005516	calmodulin binding
MF	IBA	GO:0005524	ATP binding
MF	IDA	GO:0005524	ATP binding
MF	IEA	GO:0005525	GTP binding
MF	IPI	GO:0017075	syntaxin-1 binding
MF	IPI	GO:0042802	identical protein binding

Gene expression in normal tissue: DAPK1

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in DAPK1

Database	Pathway ID	Pathway Des.
kegg	hsa04140	Autophagy - animal - Homo sapiens (human)
kegg	hsa05200	Pathways in cancer - Homo sapiens (human)
kegg	hsa05219	Bladder cancer - Homo sapiens (human)
pid	ifngpathway	IFN-gamma pathway
pid	netrin_pathway	Netrin-mediated signaling events
wikipathways	WP2828	Bladder Cancer
reactome	R-HSA-109581	Apoptosis
reactome	R-HSA-418889	via Dependence Receptors in the absence of ligand
reactome	R-HSA-5357769	Caspase activation via extrinsic apoptotic signalling pathway
reactome	R-HSA-5357801	Programmed Cell Death

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD494	Neopeltolide	2
iGMDRD424	Tamatinib	2
iGMDRD144	NSC95397	2
iGMDRD532	Olaparib	2
iGMDRD150	RITA	5
iGMDRD512	nutlin 3	3
iGMDRD280	CYTOCHALASIN B	2
iGMDRD394	BX-795	2
iGMDRD901	ELCPK	2
iGMDRD314	Tanespimycin	2
iGMDRD639	YK 4-279	2
iGMDRD446	LY 2183240	2
iGMDRD309	17AAG	1
iGMDRD231	Importazole	5
iGMDRD441	TW 37	5
iGMDRD68	Paclitaxel	2
iGMDRD434	BMS-536924	4
iGMDRD782	DC-45-A2	2
iGMDRD158	NSC141540	4
iGMDRD444	Tivantinib	2
iGMDRD356	PNU-74654	2
iGMDRD23	Gossypol	2
iGMDRD369	TGX-115	3
iGMDRD300	Tozasertib	2
iGMDRD562	Navitoclax	3
iGMDRD399	Selumetinib	2
iGMDRD730	Kahalalide F	2
iGMDRD74	Idarubicin	2
iGMDRD414	MST-312	4

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in DAPK1

SITE

DATATYPES

CLASSFICATION

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