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DAPK1

Summary: Death-associated protein kinase 1 is a positive mediator of gamma-interferon induced programmed cell death. DAPK1 encodes a structurally unique 160-kD calmodulin dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites. It is a tumor suppressor candidate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Namedeath associated protein kinase 1 OMIM IDMIM:600831 Ensembl IDEnsembl:ENSG00000196730 HGNC IDHGNC:HGNC:2674 PHARMGKB IDPA27142 Map Location9q21.33

Gene Categories:

ION CHANNEL PROTEASE SERINE THREONINE KINASE KINASE TRANSPORTER DRUGGABLE GENOME

GO terms in DAPK1

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Term Type	Evidence Type	GO Term ID	GO Des.
BP	IDA	GO:0006468	protein phosphorylation
BP	TAS	GO:0006468	protein phosphorylation
BP	IGI	GO:0006915	apoptotic process
BP	IMP	GO:0006915	apoptotic process
BP	IEA	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors
BP	TAS	GO:0010506	regulation of autophagy

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Gene expression in normal tissue: DAPK1

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in DAPK1

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Database	Pathway ID	Pathway Des.
kegg	hsa04140	Autophagy - animal - Homo sapiens (human)
kegg	hsa05200	Pathways in cancer - Homo sapiens (human)
kegg	hsa05219	Bladder cancer - Homo sapiens (human)
pid	ifngpathway	IFN-gamma pathway
pid	netrin_pathway	Netrin-mediated signaling events
wikipathways	WP2828	Bladder Cancer

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD494	Neopeltolide	2
iGMDRD424	Tamatinib	2
iGMDRD144	NSC95397	2
iGMDRD532	Olaparib	2

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in DAPK1

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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