BRD2


Summary: This gene encodes a transcriptional regulator that belongs to the BET (bromodomains and extra terminal domain) family of proteins. This protein associates with transcription complexes and with acetylated chromatin during mitosis, and it selectively binds to the acetylated lysine-12 residue of histone H4 via its two bromodomains. The gene maps to the major histocompatability complex (MHC) class II region on chromosome 6p21.3, but sequence comparison suggests that the protein is not involved in the immune response. This gene has been implicated in juvenile myoclonic epilepsy, a common form of epilepsy that becomes apparent in adolescence. Multiple alternatively spliced variants have been described for this gene. [provided by RefSeq, Dec 2010].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM IDMIM:601540
PHARMGKB IDPA25414
Map Location6p21.32

GO terms in BRD2


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Term Type
Evidence Type
GO Term ID
GO Des.
CC IDA GO:0005654 nucleoplasm
CC TAS GO:0005654 nucleoplasm
CC IEA GO:0005737 cytoplasm
CC IDA GO:0016607 nuclear speck
BP IMP GO:0006334 nucleosome assembly
BP IEA GO:0006351 transcription, DNA-templated
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Gene expression in normal tissue: BRD2

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 33LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 3BLOOtissue: BLOO cancer: BLOOD model num: 0BLOODtissue: BLOOD cancer: undefined model num: 3BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 15

Gene-drug pathway distribution

undefined13Protein stability and degradation2Longevity regulating pathway1One carbon pool by folate1Apoptosis regulation1DNA replication1

Pathways in BRD2


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Database
Pathway ID
Pathway Des.
wikipathways WP3295 Chemical Compounds to monitor Proteins
pid rb_1pathway Regulation of retinoblastoma protein
reactome R-HSA-212436 Generic Transcription Pathway
reactome R-HSA-73857 RNA Polymerase II Transcription
reactome R-HSA-74160 Gene expression (Transcription)
reactome R-HSA-8878159 Transcriptional regulation by RUNX3
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD562 Navitoclax 3
iGMDRD888 Compound 44 1
iGMDRD74 Idarubicin 2
iGMDRD187 BRD9876 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in BRD2

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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