DAND5
Summary: This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to bind Nodal and to inhibit the Nodal signaling pathway which patterns left/right body asymmetry. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| DAN domain BMP antagonist family member 5 | MIM:609068 | Ensembl:ENSG00000179284 | HGNC:HGNC:26780 | PA134875268 | 19p13.13 |
Gene Categories:
DRUGGABLE GENOMEGO terms in DAND5
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0016015 | morphogen activity |
| MF | ISS | GO:0016015 | morphogen activity |
| CC | NAS | GO:0005576 | extracellular region |
| CC | IBA | GO:0005615 | extracellular space |
| BP | ISS | GO:0003140 | determination of left/right asymmetry in lateral mesoderm |
| BP | ISS | GO:0003281 | ventricular septum development |
| BP | ISS | GO:0003283 | atrial septum development |
| BP | IEA | GO:0010469 | regulation of signaling receptor activity |
| BP | IBA | GO:0023019 | signal transduction involved in regulation of gene expression |
| BP | ISS | GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway |
| BP | ISS | GO:0030514 | negative regulation of BMP signaling pathway |
| BP | IBA | GO:0035582 | sequestering of BMP in extracellular matrix |
| BP | ISS | GO:0038101 | sequestering of nodal from receptor via nodal binding |
| BP | IBA | GO:0061371 | determination of heart left/right asymmetry |
| BP | ISS | GO:0061371 | determination of heart left/right asymmetry |
| BP | ISS | GO:1900108 | negative regulation of nodal signaling pathway |
| BP | IBA | GO:1900176 | negative regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry |
Gene expression in normal tissue: DAND5
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in DAND5
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1181150 | Signaling by NODAL |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1433617 | Regulation of signaling by NODAL |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD213 | SMR000068650 | 3 |
| iGMDRD52 | Rotenone | 3 |
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD353 | PD0325901 | 2 |
| iGMDRD82 | Quiflapon | 3 |
| iGMDRD356 | PNU-74654 | 1 |
| iGMDRD888 | Compound 44 | 3 |
| iGMDRD100 | Zebularine | 3 |
| iGMDRD872 | BRD7137 | 6 |
| iGMDRD74 | Idarubicin | 3 |
| iGMDRD579 | PF750 | 3 |
| iGMDRD772 | BRD4770 | 3 |
| iGMDRD679 | Bistramide A | 1 |
| iGMDRD316 | N9-Isopropyl-olomoucine | 3 |
| iGMDRD341 | Triacsin c | 3 |
| iGMDRD201 | SKI II | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in DAND5
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