DAND5
Summary: This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to bind Nodal and to inhibit the Nodal signaling pathway which patterns left/right body asymmetry. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:609068 Ensembl IDEnsembl:ENSG00000179284 HGNC IDHGNC:HGNC:26780 PHARMGKB IDPA134875268 Map Location19p13.13 | |||||
Gene Categories:
DRUGGABLE GENOMEGO terms in DAND5
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0016015 | morphogen activity |
| MF | ISS | GO:0016015 | morphogen activity |
| CC | NAS | GO:0005576 | extracellular region |
| CC | IBA | GO:0005615 | extracellular space |
| BP | ISS | GO:0003140 | determination of left/right asymmetry in lateral mesoderm |
| BP | ISS | GO:0003281 | ventricular septum development |
Gene expression in normal tissue: DAND5
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in DAND5
Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1181150 | Signaling by NODAL |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1433617 | Regulation of signaling by NODAL |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in DAND5
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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