NIN
Summary: This gene encodes one of the proteins important for centrosomal function. This protein is important for positioning and anchoring the microtubules minus-ends in epithelial cells. Localization of this protein to the centrosome requires three leucine zippers in the central coiled-coil domain. Multiple alternatively spliced transcript variants that encode different isoforms have been reported. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ninein | MIM:608684 | Ensembl:ENSG00000100503 | HGNC:HGNC:14906 | PA31630 | 14q22.1 |
GO terms in NIN
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0005509 | calcium ion binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005525 | GTP binding |
| CC | IBA | GO:0000242 | pericentriolar material |
| CC | IDA | GO:0000242 | pericentriolar material |
| CC | IMP | GO:0000922 | spindle pole |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005730 | nucleolus |
| CC | IDA | GO:0005813 | centrosome |
| CC | IBA | GO:0005814 | centriole |
| CC | IDA | GO:0005814 | centriole |
| CC | IBA | GO:0036449 | microtubule minus-end |
| CC | IDA | GO:0072686 | mitotic spindle |
| CC | IBA | GO:0097431 | mitotic spindle pole |
| CC | IBA | GO:0097539 | ciliary transition fiber |
| CC | IDA | GO:0120103 | centriolar subdistal appendage |
| BP | IBA | GO:0000226 | microtubule cytoskeleton organization |
| BP | IMP | GO:0008104 | protein localization |
| BP | IMP | GO:0010457 | centriole-centriole cohesion |
| BP | IBA | GO:0034454 | microtubule anchoring at centrosome |
| BP | IMP | GO:0034454 | microtubule anchoring at centrosome |
| BP | IBA | GO:0051642 | centrosome localization |
| BP | TAS | GO:0051642 | centrosome localization |
| BP | IBA | GO:0090222 | centrosome-templated microtubule nucleation |
Gene expression in normal tissue: NIN
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NIN
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD481 | Dactolisib | 5 |
| iGMDRD705 | Nakiterpiosin | 4 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD121 | GMX1778 | 2 |
| iGMDRD137 | Indisulam | 2 |
| iGMDRD202 | Curcumin | 3 |
| iGMDRD353 | PD0325901 | 1 |
| iGMDRD505 | Pevonedistat | 6 |
| iGMDRD300 | Tozasertib | 3 |
| iGMDRD662 | JQ-1 | 1 |
| iGMDRD405 | PIK-75 | 5 |
| iGMDRD299 | ICL 670 | 1 |
| iGMDRD47 | ZM336372 | 1 |
| iGMDRD435 | BI-2536 | 3 |
| iGMDRD883 | CIL55A | 1 |
| iGMDRD901 | ELCPK | 1 |
| iGMDRD351 | GW843682X | 3 |
| iGMDRD57 | Chloropentafluorobenzene | 3 |
| iGMDRD237 | ABT-751 | 2 |
| iGMDRD226 | ML006 | 3 |
| iGMDRD885 | Compound 110 | 3 |
| iGMDRD52 | Rotenone | 1 |
| iGMDRD171 | Pemetrexed | 1 |
| iGMDRD260 | FQI-2 | 1 |
| iGMDRD524 | ISX-9 | 1 |
| iGMDRD60 | Quinoclamine | 2 |
| iGMDRD64 | Parbendazole | 1 |
| iGMDRD888 | Compound 44 | 3 |
| iGMDRD506 | Fedratinib | 3 |
| iGMDRD74 | Idarubicin | 1 |
| iGMDRD887 | Compound 23 citrate | 1 |
| iGMDRD494 | Neopeltolide | 2 |
| iGMDRD781 | Sirolimus | 1 |
| iGMDRD670 | ML 210 | 5 |
| iGMDRD546 | BMS-754807 | 5 |
| iGMDRD387 | CHIR-99021 | 1 |
| iGMDRD420 | Leucascandrolide A | 2 |
| iGMDRD151 | CHM-1 | 2 |
| iGMDRD634 | SCHEMBL2608041 | 4 |
| iGMDRD394 | BX-795 | 1 |
| iGMDRD466 | Chaetocin | 2 |
| iGMDRD193 | Fqi1 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NIN
CLASSFICATION
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