TLK1
Summary: The protein encoded by this gene is a serine/threonine kinase that may be involved in the regulation of chromatin assembly. The encoded protein is only active when it is phosphorylated, and this phosphorylation is cell cycle-dependent, with the maximal activity of this protein coming during S phase. The catalytic activity of this protein is diminished by DNA damage and by blockage of DNA replication. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| tousled like kinase 1 | MIM:608438 | Ensembl:ENSG00000198586 | HGNC:HGNC:11841 | PA36543 | 2q31.1 |
GO terms in TLK1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IDA | GO:0001672 | regulation of chromatin assembly or disassembly |
| BP | IEA | GO:0006325 | chromatin organization |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | IDA | GO:0006886 | intracellular protein transport |
| BP | IEA | GO:0006974 | cellular response to DNA damage stimulus |
| BP | IEA | GO:0007049 | cell cycle |
| BP | IDA | GO:0035556 | intracellular signal transduction |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005634 | nucleus |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | TAS | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0005524 | ATP binding |
Gene expression in normal tissue: TLK1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TLK1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP1530 | miRNA Regulation of DNA Damage Response |
| wikipathways | WP3651 | Pathways Affected in Adenoid Cystic Carcinoma |
| wikipathways | WP707 | DNA Damage Response |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD451 | Serdemetan | 3 |
| iGMDRD524 | ISX-9 | 3 |
| iGMDRD356 | PNU-74654 | 3 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD398 | Sepantronium | 1 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD506 | Fedratinib | 4 |
| iGMDRD74 | Idarubicin | 3 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD100 | Zebularine | 3 |
| iGMDRD52 | Rotenone | 3 |
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD5 | Tyrphostin AG 1478 | 3 |
| iGMDRD802 | 4-methylfasudil | 3 |
| iGMDRD138 | PX 12 | 3 |
| iGMDRD121 | GMX1778 | 3 |
| iGMDRD270 | Ciclosporin | 3 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD466 | Chaetocin | 3 |
| iGMDRD901 | ELCPK | 3 |
| iGMDRD351 | GW843682X | 3 |
| iGMDRD494 | Neopeltolide | 3 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD126 | Tipifarnib | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TLK1
CLASSFICATION
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