TLK1
Summary: The protein encoded by this gene is a serine/threonine kinase that may be involved in the regulation of chromatin assembly. The encoded protein is only active when it is phosphorylated, and this phosphorylation is cell cycle-dependent, with the maximal activity of this protein coming during S phase. The catalytic activity of this protein is diminished by DNA damage and by blockage of DNA replication. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:608438 Ensembl IDEnsembl:ENSG00000198586 HGNC IDHGNC:HGNC:11841 PHARMGKB IDPA36543 Map Location2q31.1 | |||||
GO terms in TLK1
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IDA | GO:0001672 | regulation of chromatin assembly or disassembly |
| BP | IEA | GO:0006325 | chromatin organization |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | IDA | GO:0006886 | intracellular protein transport |
| BP | IEA | GO:0006974 | cellular response to DNA damage stimulus |
| BP | IEA | GO:0007049 | cell cycle |
Gene expression in normal tissue: TLK1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TLK1
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TLK1
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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