MLKL


Summary: This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
mixed lineage kinase domain like pseudokinaseMIM:615153Ensembl:ENSG00000168404HGNC:HGNC:26617PA14267134916q23.1

GO terms in MLKL


Term TypeEvidence TypeGO Term IDGO Des.
CCIDAGO:0005737cytoplasm
CCTASGO:0005829cytosol
CCIDAGO:0005886plasma membrane
BPIBAGO:0000165MAPK cascade
BPIEAGO:0007166cell surface receptor signaling pathway
BPIBAGO:0007257activation of JUN kinase activity
BPIDAGO:0070207protein homotrimerization
BPIMPGO:0070266necroptotic process
BPTASGO:0070266necroptotic process
MFISSGO:0004672protein kinase activity
MFIBAGO:0004674protein serine/threonine kinase activity
MFIBAGO:0004706JUN kinase kinase kinase activity
MFIPIGO:0005515protein binding
MFIDAGO:0005524ATP binding
MFIEAGO:0019901protein kinase binding
MFIDAGO:0044877protein-containing complex binding

Gene expression in normal tissue: MLKL

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MLKL


DatabasePathway IDPathway Des.
kegghsa04217Necroptosis - Homo sapiens (human)
kegghsa04668TNF signaling pathway - Homo sapiens (human)
wikipathwaysWP710DNA Damage Response (only ATM dependent)
reactomeR-HSA-2672351Stimuli-sensing channels
reactomeR-HSA-3295583TRP channels
reactomeR-HSA-382551Transport of small molecules
reactomeR-HSA-5213460RIPK1-mediated regulated necrosis
reactomeR-HSA-5218859Regulated Necrosis
reactomeR-HSA-5357801Programmed Cell Death
reactomeR-HSA-983712Ion channel transport

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD512nutlin 36
iGMDRD599Salermide3
iGMDRD84Lovastatin acid2
iGMDRD126Tipifarnib2
iGMDRD532Olaparib2
iGMDRD116CD4372
iGMDRD424Tamatinib2
iGMDRD427ABT7374
iGMDRD314Tanespimycin2
iGMDRD639YK 4-2792
iGMDRD901ELCPK2
iGMDRD280CYTOCHALASIN B1
iGMDRD158NSC1415402
iGMDRD267Oligomycin A1
iGMDRD30917AAG2
iGMDRD782DC-45-A22
iGMDRD562Navitoclax4
iGMDRD398Sepantronium7
iGMDRD871BRD63682
iGMDRD367Ro 28-16752
iGMDRD74Idarubicin2
iGMDRD730Kahalalide F2
iGMDRD23Gossypol2
iGMDRD353PD03259012
iGMDRD444Tivantinib2
iGMDRD300Tozasertib2
iGMDRD246NPC262

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MLKL

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