CLTCL1


Summary: This gene is a member of the clathrin heavy chain family and encodes a major protein of the polyhedral coat of coated pits and vesicles. Chromosomal aberrations involving this gene are associated with meningioma, DiGeorge syndrome, and velo-cardio-facial syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009].

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Name
OMIM ID
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PHARMGKB ID
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GO terms in CLTCL1


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Term Type
Evidence Type
GO Term ID
GO Des.
CC IDA GO:0005769 early endosome
CC IBA GO:0005770 late endosome
CC IDA GO:0005770 late endosome
CC IBA GO:0005802 trans-Golgi network
CC IDA GO:0005802 trans-Golgi network
CC IBA GO:0005819 spindle
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Gene expression in normal tissue: CLTCL1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined51Apoptosis regulation1Biosynthesis of secondary metabolites1p53 pathway1RTK signaling1Other, kinases1ERK MAPK signaling1Cell cycle1Purine metabolism1Metabolism1

Pathways in CLTCL1


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Database
Pathway ID
Pathway Des.
reactome R-HSA-1266738 Developmental Biology
reactome R-HSA-157858 Gap junction trafficking and regulation
reactome R-HSA-190828 Gap junction trafficking
reactome R-HSA-190873 Gap junction degradation
reactome R-HSA-196025 Formation of annular gap junctions
reactome R-HSA-199991 Membrane Trafficking
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD57 Chloropentafluorobenzene 3
iGMDRD237 ABT-751 3
iGMDRD901 ELCPK 3
iGMDRD123 Isoevodiamine 4
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CLTCL1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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