AXL


Summary: The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
AXL receptor tyrosine kinaseMIM:109135Ensembl:ENSG00000167601HGNC:HGNC:905PA2519719q13.2

GO terms in AXL


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0001618virus receptor activity
MFIDAGO:0001786phosphatidylserine binding
MFIBAGO:0004709MAP kinase kinase kinase activity
MFEXPGO:0004713protein tyrosine kinase activity
MFIBAGO:0004713protein tyrosine kinase activity
MFIBAGO:0004714transmembrane receptor protein tyrosine kinase activity
MFIEAGO:0004714transmembrane receptor protein tyrosine kinase activity
MFIBAGO:0004888transmembrane signaling receptor activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIBAGO:0017147Wnt-protein binding
MFIBAGO:0031434mitogen-activated protein kinase kinase binding
MFIEAGO:0032036myosin heavy chain binding
MFIEAGO:0043548phosphatidylinositol 3-kinase binding
MFIEAGO:0046982protein heterodimerization activity
BPIEAGO:0001764neuron migration
BPIEAGO:0001779natural killer cell differentiation
BPIDAGO:0001961positive regulation of cytokine-mediated signaling pathway
BPIEAGO:0001974blood vessel remodeling
BPIBAGO:0006909phagocytosis
BPIDAGO:0006909phagocytosis
BPIEAGO:0006954inflammatory response
BPTASGO:0007165signal transduction
BPIBAGO:0007275multicellular organism development
BPIEAGO:0007283spermatogenesis
BPIBAGO:0009968negative regulation of signal transduction
BPIBAGO:0016055Wnt signaling pathway
BPIEAGO:0018108peptidyl-tyrosine phosphorylation
BPIEAGO:0021885forebrain cell migration
BPIBAGO:0030154cell differentiation
BPIEAGO:0030168platelet activation
BPIEAGO:0031100animal organ regeneration
BPIEAGO:0031668cellular response to extracellular stimulus
BPIDAGO:0032689negative regulation of interferon-gamma production
BPIEAGO:0032720negative regulation of tumor necrosis factor production
BPIDAGO:0032825positive regulation of natural killer cell differentiation
BPIEAGO:0032940secretion by cell
BPIBAGO:0033674positive regulation of kinase activity
BPIEAGO:0034101erythrocyte homeostasis
BPIEAGO:0034446substrate adhesion-dependent cell spreading
BPIDAGO:0035457cellular response to interferon-alpha
BPIEAGO:0042698ovulation cycle
BPIBAGO:0043066negative regulation of apoptotic process
BPIEAGO:0043277apoptotic cell clearance
BPIBAGO:0043410positive regulation of MAPK cascade
BPIEAGO:0043491protein kinase B signaling
BPIEAGO:0043524negative regulation of neuron apoptotic process
BPIEAGO:0045087innate immune response
BPIMPGO:0046718viral entry into host cell
BPTASGO:0048010vascular endothelial growth factor receptor signaling pathway
BPIEPGO:0048469cell maturation
BPIMPGO:0048549positive regulation of pinocytosis
BPIEAGO:0051250negative regulation of lymphocyte activation
BPIEAGO:0051897positive regulation of protein kinase B signaling
BPIEAGO:0060068vagina development
BPIEAGO:0070301cellular response to hydrogen peroxide
BPIBAGO:0070374positive regulation of ERK1 and ERK2 cascade
BPIDAGO:0071222cellular response to lipopolysaccharide
BPIEPGO:0097028dendritic cell differentiation
BPIEAGO:0097350neutrophil clearance
BPIDAGO:2000669negative regulation of dendritic cell apoptotic process
CCIDAGO:0005615extracellular space
CCIEAGO:0005622intracellular
CCIBAGO:0005737cytoplasm
CCTASGO:0005886plasma membrane
CCIBAGO:0005887integral component of plasma membrane
CCTASGO:0005887integral component of plasma membrane
CCHDAGO:0009986cell surface
CCIDAGO:0009986cell surface
CCIBAGO:0043235receptor complex
CCIDAGO:0044228host cell surface
CCHDAGO:0070062extracellular exosome

Gene expression in normal tissue: AXL

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in AXL


DatabasePathway IDPathway Des.
wikipathwaysWP2004miR-targeted genes in lymphocytes - TarBase
wikipathwaysWP2005miR-targeted genes in muscle cell - TarBase
wikipathwaysWP2006miR-targeted genes in squamous cell - TarBase
wikipathwaysWP4180Ebola Virus Pathway on Host
wikipathwaysWP4217Ebola Virus Pathway on Host
piddeltanp63pathwayValidated transcriptional targets of deltaNp63 isoforms
netpathPathway_EGFR1EGFR1
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-194138Signaling by VEGF
reactomeR-HSA-4420097VEGFA-VEGFR2 Pathway
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD434BMS-5369246
iGMDRD289Parthenolide3
iGMDRD158NSC1415403
iGMDRD121GMX17786
iGMDRD246NPC262
iGMDRD322FK 8663
iGMDRD286Nsc 6328392
iGMDRD871BRD63682
iGMDRD366PI-1032
iGMDRD269Purmorphamine1
iGMDRD424Tamatinib3
iGMDRD79Gemcitabine2
iGMDRD307Manumycin A3
iGMDRD123Isoevodiamine3
iGMDRD177Teniposide2
iGMDRD57Chloropentafluorobenzene2
iGMDRD52Rotenone1
iGMDRD8012,4-dideoxy-DC-45-A23
iGMDRD138PX 123
iGMDRD255SB2250022
iGMDRD369TGX-1153
iGMDRD64Parbendazole3
iGMDRD690PRIMA-1MET3
iGMDRD524ISX-92
iGMDRD268Cerulenin1
iGMDRD74Idarubicin3
iGMDRD188Piperlongumine1
iGMDRD100Zebularine4
iGMDRD398Sepantronium2
iGMDRD562Navitoclax2
iGMDRD577BIX012942
iGMDRD888Compound 441
iGMDRD779PRL-3 Inhibitor I1
iGMDRD546BMS-7548072
iGMDRD427ABT7372
iGMDRD483SCH-5290741
iGMDRD126Tipifarnib2
iGMDRD1008SR-II-138A3
iGMDRD420Leucascandrolide A1
iGMDRD466Chaetocin4
iGMDRD280CYTOCHALASIN B2
iGMDRD297Austocystin D1
iGMDRD375GW-4058331
iGMDRD61Kinetin riboside1
iGMDRD639YK 4-2793

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in AXL

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