AXL
Summary: The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:109135 Ensembl IDEnsembl:ENSG00000167601 HGNC IDHGNC:HGNC:905 PHARMGKB IDPA25197 Map Location19q13.2 | |||||
GO terms in AXL
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0001618 | virus receptor activity |
| MF | IDA | GO:0001786 | phosphatidylserine binding |
| MF | IBA | GO:0004709 | MAP kinase kinase kinase activity |
| MF | EXP | GO:0004713 | protein tyrosine kinase activity |
| MF | IBA | GO:0004713 | protein tyrosine kinase activity |
| MF | IBA | GO:0004714 | transmembrane receptor protein tyrosine kinase activity |
Gene expression in normal tissue: AXL
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in AXL
Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
| wikipathways | WP2005 | miR-targeted genes in muscle cell - TarBase |
| wikipathways | WP2006 | miR-targeted genes in squamous cell - TarBase |
| wikipathways | WP4180 | Ebola Virus Pathway on Host |
| wikipathways | WP4217 | Ebola Virus Pathway on Host |
| pid | deltanp63pathway | Validated transcriptional targets of deltaNp63 isoforms |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in AXL
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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