AXL
Summary: The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| AXL receptor tyrosine kinase | MIM:109135 | Ensembl:ENSG00000167601 | HGNC:HGNC:905 | PA25197 | 19q13.2 |
GO terms in AXL
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0001618 | virus receptor activity |
| MF | IDA | GO:0001786 | phosphatidylserine binding |
| MF | IBA | GO:0004709 | MAP kinase kinase kinase activity |
| MF | EXP | GO:0004713 | protein tyrosine kinase activity |
| MF | IBA | GO:0004713 | protein tyrosine kinase activity |
| MF | IBA | GO:0004714 | transmembrane receptor protein tyrosine kinase activity |
| MF | IEA | GO:0004714 | transmembrane receptor protein tyrosine kinase activity |
| MF | IBA | GO:0004888 | transmembrane signaling receptor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IBA | GO:0017147 | Wnt-protein binding |
| MF | IBA | GO:0031434 | mitogen-activated protein kinase kinase binding |
| MF | IEA | GO:0032036 | myosin heavy chain binding |
| MF | IEA | GO:0043548 | phosphatidylinositol 3-kinase binding |
| MF | IEA | GO:0046982 | protein heterodimerization activity |
| BP | IEA | GO:0001764 | neuron migration |
| BP | IEA | GO:0001779 | natural killer cell differentiation |
| BP | IDA | GO:0001961 | positive regulation of cytokine-mediated signaling pathway |
| BP | IEA | GO:0001974 | blood vessel remodeling |
| BP | IBA | GO:0006909 | phagocytosis |
| BP | IDA | GO:0006909 | phagocytosis |
| BP | IEA | GO:0006954 | inflammatory response |
| BP | TAS | GO:0007165 | signal transduction |
| BP | IBA | GO:0007275 | multicellular organism development |
| BP | IEA | GO:0007283 | spermatogenesis |
| BP | IBA | GO:0009968 | negative regulation of signal transduction |
| BP | IBA | GO:0016055 | Wnt signaling pathway |
| BP | IEA | GO:0018108 | peptidyl-tyrosine phosphorylation |
| BP | IEA | GO:0021885 | forebrain cell migration |
| BP | IBA | GO:0030154 | cell differentiation |
| BP | IEA | GO:0030168 | platelet activation |
| BP | IEA | GO:0031100 | animal organ regeneration |
| BP | IEA | GO:0031668 | cellular response to extracellular stimulus |
| BP | IDA | GO:0032689 | negative regulation of interferon-gamma production |
| BP | IEA | GO:0032720 | negative regulation of tumor necrosis factor production |
| BP | IDA | GO:0032825 | positive regulation of natural killer cell differentiation |
| BP | IEA | GO:0032940 | secretion by cell |
| BP | IBA | GO:0033674 | positive regulation of kinase activity |
| BP | IEA | GO:0034101 | erythrocyte homeostasis |
| BP | IEA | GO:0034446 | substrate adhesion-dependent cell spreading |
| BP | IDA | GO:0035457 | cellular response to interferon-alpha |
| BP | IEA | GO:0042698 | ovulation cycle |
| BP | IBA | GO:0043066 | negative regulation of apoptotic process |
| BP | IEA | GO:0043277 | apoptotic cell clearance |
| BP | IBA | GO:0043410 | positive regulation of MAPK cascade |
| BP | IEA | GO:0043491 | protein kinase B signaling |
| BP | IEA | GO:0043524 | negative regulation of neuron apoptotic process |
| BP | IEA | GO:0045087 | innate immune response |
| BP | IMP | GO:0046718 | viral entry into host cell |
| BP | TAS | GO:0048010 | vascular endothelial growth factor receptor signaling pathway |
| BP | IEP | GO:0048469 | cell maturation |
| BP | IMP | GO:0048549 | positive regulation of pinocytosis |
| BP | IEA | GO:0051250 | negative regulation of lymphocyte activation |
| BP | IEA | GO:0051897 | positive regulation of protein kinase B signaling |
| BP | IEA | GO:0060068 | vagina development |
| BP | IEA | GO:0070301 | cellular response to hydrogen peroxide |
| BP | IBA | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| BP | IDA | GO:0071222 | cellular response to lipopolysaccharide |
| BP | IEP | GO:0097028 | dendritic cell differentiation |
| BP | IEA | GO:0097350 | neutrophil clearance |
| BP | IDA | GO:2000669 | negative regulation of dendritic cell apoptotic process |
| CC | IDA | GO:0005615 | extracellular space |
| CC | IEA | GO:0005622 | intracellular |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005887 | integral component of plasma membrane |
| CC | TAS | GO:0005887 | integral component of plasma membrane |
| CC | HDA | GO:0009986 | cell surface |
| CC | IDA | GO:0009986 | cell surface |
| CC | IBA | GO:0043235 | receptor complex |
| CC | IDA | GO:0044228 | host cell surface |
| CC | HDA | GO:0070062 | extracellular exosome |
Gene expression in normal tissue: AXL
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in AXL
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
| wikipathways | WP2005 | miR-targeted genes in muscle cell - TarBase |
| wikipathways | WP2006 | miR-targeted genes in squamous cell - TarBase |
| wikipathways | WP4180 | Ebola Virus Pathway on Host |
| wikipathways | WP4217 | Ebola Virus Pathway on Host |
| pid | deltanp63pathway | Validated transcriptional targets of deltaNp63 isoforms |
| netpath | Pathway_EGFR1 | EGFR1 |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-194138 | Signaling by VEGF |
| reactome | R-HSA-4420097 | VEGFA-VEGFR2 Pathway |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD434 | BMS-536924 | 6 |
| iGMDRD289 | Parthenolide | 3 |
| iGMDRD158 | NSC141540 | 3 |
| iGMDRD121 | GMX1778 | 6 |
| iGMDRD246 | NPC26 | 2 |
| iGMDRD322 | FK 866 | 3 |
| iGMDRD286 | Nsc 632839 | 2 |
| iGMDRD871 | BRD6368 | 2 |
| iGMDRD366 | PI-103 | 2 |
| iGMDRD269 | Purmorphamine | 1 |
| iGMDRD424 | Tamatinib | 3 |
| iGMDRD79 | Gemcitabine | 2 |
| iGMDRD307 | Manumycin A | 3 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD177 | Teniposide | 2 |
| iGMDRD57 | Chloropentafluorobenzene | 2 |
| iGMDRD52 | Rotenone | 1 |
| iGMDRD801 | 2,4-dideoxy-DC-45-A2 | 3 |
| iGMDRD138 | PX 12 | 3 |
| iGMDRD255 | SB225002 | 2 |
| iGMDRD369 | TGX-115 | 3 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD690 | PRIMA-1MET | 3 |
| iGMDRD524 | ISX-9 | 2 |
| iGMDRD268 | Cerulenin | 1 |
| iGMDRD74 | Idarubicin | 3 |
| iGMDRD188 | Piperlongumine | 1 |
| iGMDRD100 | Zebularine | 4 |
| iGMDRD398 | Sepantronium | 2 |
| iGMDRD562 | Navitoclax | 2 |
| iGMDRD577 | BIX01294 | 2 |
| iGMDRD888 | Compound 44 | 1 |
| iGMDRD779 | PRL-3 Inhibitor I | 1 |
| iGMDRD546 | BMS-754807 | 2 |
| iGMDRD427 | ABT737 | 2 |
| iGMDRD483 | SCH-529074 | 1 |
| iGMDRD126 | Tipifarnib | 2 |
| iGMDRD1008 | SR-II-138A | 3 |
| iGMDRD420 | Leucascandrolide A | 1 |
| iGMDRD466 | Chaetocin | 4 |
| iGMDRD280 | CYTOCHALASIN B | 2 |
| iGMDRD297 | Austocystin D | 1 |
| iGMDRD375 | GW-405833 | 1 |
| iGMDRD61 | Kinetin riboside | 1 |
| iGMDRD639 | YK 4-279 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in AXL
CLASSFICATION
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