GATA2


Summary: This gene encodes a member of the GATA family of zinc-finger transcription factors that are named for the consensus nucleotide sequence they bind in the promoter regions of target genes. The encoded protein plays an essential role in regulating transcription of genes involved in the development and proliferation of hematopoietic and endocrine cell lineages. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM IDMIM:137295
PHARMGKB IDPA28585
Map Location3q21.3

GO terms in GATA2


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IBA GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding
MF IEA GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding
MF IEA GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding
MF IDA GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF ISM GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF NAS GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
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Gene expression in normal tissue: GATA2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in GATA2


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Database
Pathway ID
Pathway Des.
reactome R-HSA-109582 Hemostasis
reactome R-HSA-212436 Generic Transcription Pathway
reactome R-HSA-73857 RNA Polymerase II Transcription
reactome R-HSA-74160 Gene expression (Transcription)
reactome R-HSA-8878171 Transcriptional regulation by RUNX1
reactome R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD82 Quiflapon 2
iGMDRD213 SMR000068650 2
iGMDRD267 Oligomycin A 3
iGMDRD68 Paclitaxel 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GATA2

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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