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GATA2

Summary: This gene encodes a member of the GATA family of zinc-finger transcription factors that are named for the consensus nucleotide sequence they bind in the promoter regions of target genes. The encoded protein plays an essential role in regulating transcription of genes involved in the development and proliferation of hematopoietic and endocrine cell lineages. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
NameGATA binding protein 2 OMIM IDMIM:137295 Ensembl IDEnsembl:ENSG00000179348 HGNC IDHGNC:HGNC:4171 PHARMGKB IDPA28585 Map Location3q21.3

Gene Categories:

TRANSCRIPTION FACTOR BINDING TRANSCRIPTION FACTOR COMPLEX CLINICALLY ACTIONABLE HISTONE MODIFICATION

GO terms in GATA2

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Term Type	Evidence Type	GO Term ID	GO Des.
MF	IBA	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding
MF	IEA	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding
MF	IEA	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
MF	IDA	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF	ISM	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF	NAS	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding

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Gene expression in normal tissue: GATA2

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in GATA2

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Database	Pathway ID	Pathway Des.
reactome	R-HSA-109582	Hemostasis
reactome	R-HSA-212436	Generic Transcription Pathway
reactome	R-HSA-73857	RNA Polymerase II Transcription
reactome	R-HSA-74160	Gene expression (Transcription)
reactome	R-HSA-8878171	Transcriptional regulation by RUNX1
reactome	R-HSA-8939236	RUNX1 regulates transcription of genes involved in differentiation of HSCs

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD82	Quiflapon	2
iGMDRD213	SMR000068650	2
iGMDRD267	Oligomycin A	3
iGMDRD68	Paclitaxel	1

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GATA2

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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