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GATA2

Summary: This gene encodes a member of the GATA family of zinc-finger transcription factors that are named for the consensus nucleotide sequence they bind in the promoter regions of target genes. The encoded protein plays an essential role in regulating transcription of genes involved in the development and proliferation of hematopoietic and endocrine cell lineages. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
GATA binding protein 2	MIM:137295	Ensembl:ENSG00000179348	HGNC:HGNC:4171	PA28585	3q21.3

Gene Categories:

TRANSCRIPTION FACTOR BINDING TRANSCRIPTION FACTOR COMPLEX CLINICALLY ACTIONABLE HISTONE MODIFICATION

GO terms in GATA2

Term Type	Evidence Type	GO Term ID	GO Des.
MF	IBA	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding
MF	IEA	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding
MF	IEA	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
MF	IDA	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF	ISM	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF	NAS	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF	IBA	GO:0001076	transcription factor activity, RNA polymerase II transcription factor binding
MF	IBA	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MF	IEA	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MF	IDA	GO:0001158	enhancer sequence-specific DNA binding
MF	IDA	GO:0003682	chromatin binding
MF	IBA	GO:0003700	DNA-binding transcription factor activity
MF	IDA	GO:0003700	DNA-binding transcription factor activity
MF	IPI	GO:0005515	protein binding
MF	IPI	GO:0008134	transcription factor binding
MF	IEA	GO:0008270	zinc ion binding
MF	IPI	GO:0070742	C2H2 zinc finger domain binding
CC	IBA	GO:0005634	nucleus
CC	IDA	GO:0005634	nucleus
CC	IDA	GO:0005654	nucleoplasm
CC	TAS	GO:0005654	nucleoplasm
CC	IDA	GO:0005737	cytoplasm
BP	IEA	GO:0000122	negative regulation of transcription by RNA polymerase II
BP	IEA	GO:0001655	urogenital system development
BP	IEA	GO:0001709	cell fate determination
BP	IEA	GO:0001764	neuron migration
BP	IEA	GO:0001892	embryonic placenta development
BP	IDA	GO:0006351	transcription, DNA-templated
BP	IEA	GO:0006909	phagocytosis
BP	IEA	GO:0007204	positive regulation of cytosolic calcium ion concentration
BP	IBA	GO:0007507	heart development
BP	TAS	GO:0007596	blood coagulation
BP	IBA	GO:0009887	animal organ morphogenesis
BP	IBA	GO:0009888	tissue development
BP	IGI	GO:0010628	positive regulation of gene expression
BP	IMP	GO:0010628	positive regulation of gene expression
BP	IMP	GO:0010629	negative regulation of gene expression
BP	IEA	GO:0010725	regulation of primitive erythrocyte differentiation
BP	IEA	GO:0021514	ventral spinal cord interneuron differentiation
BP	IEA	GO:0021533	cell differentiation in hindbrain
BP	IEA	GO:0021902	commitment of neuronal cell to specific neuron type in forebrain
BP	IEA	GO:0021954	central nervous system neuron development
BP	IEA	GO:0021983	pituitary gland development
BP	IEA	GO:0033993	response to lipid
BP	IEA	GO:0035019	somatic stem cell population maintenance
BP	IEA	GO:0035065	regulation of histone acetylation
BP	IDA	GO:0035854	eosinophil fate commitment
BP	IEA	GO:0042472	inner ear morphogenesis
BP	IEA	GO:0043306	positive regulation of mast cell degranulation
BP	IBA	GO:0045165	cell fate commitment
BP	IMP	GO:0045599	negative regulation of fat cell differentiation
BP	IEA	GO:0045648	positive regulation of erythrocyte differentiation
BP	IEA	GO:0045650	negative regulation of macrophage differentiation
BP	IEA	GO:0045654	positive regulation of megakaryocyte differentiation
BP	IEA	GO:0045666	positive regulation of neuron differentiation
BP	IDA	GO:0045746	negative regulation of Notch signaling pathway
BP	IDA	GO:0045766	positive regulation of angiogenesis
BP	IMP	GO:0045766	positive regulation of angiogenesis
BP	IDA	GO:0045944	positive regulation of transcription by RNA polymerase II
BP	IGI	GO:0045944	positive regulation of transcription by RNA polymerase II
BP	IMP	GO:0045944	positive regulation of transcription by RNA polymerase II
BP	IBA	GO:0048468	cell development
BP	IEA	GO:0048469	cell maturation
BP	IBA	GO:0048565	digestive tract development
BP	IBA	GO:0048646	anatomical structure formation involved in morphogenesis
BP	IEA	GO:0048873	homeostasis of number of cells within a tissue
BP	ISS	GO:0050766	positive regulation of phagocytosis
BP	IEA	GO:0060100	positive regulation of phagocytosis, engulfment
BP	IEA	GO:0060216	definitive hemopoiesis
BP	IEA	GO:0060872	semicircular canal development
BP	IDA	GO:0061614	pri-miRNA transcription by RNA polymerase II
BP	IMP	GO:0070345	negative regulation of fat cell proliferation
BP	IMP	GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis
BP	IEA	GO:0090102	cochlea development
BP	IEA	GO:0097154	GABAergic neuron differentiation
BP	TAS	GO:1902036	regulation of hematopoietic stem cell differentiation
BP	IMP	GO:1903589	positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
BP	IDA	GO:2000178	negative regulation of neural precursor cell proliferation
BP	IMP	GO:2000352	negative regulation of endothelial cell apoptotic process
BP	IEA	GO:2000977	regulation of forebrain neuron differentiation

Gene expression in normal tissue: GATA2

Select Project:

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in GATA2

Database	Pathway ID	Pathway Des.
reactome	R-HSA-109582	Hemostasis
reactome	R-HSA-212436	Generic Transcription Pathway
reactome	R-HSA-73857	RNA Polymerase II Transcription
reactome	R-HSA-74160	Gene expression (Transcription)
reactome	R-HSA-8878171	Transcriptional regulation by RUNX1
reactome	R-HSA-8939236	RUNX1 regulates transcription of genes involved in differentiation of HSCs
reactome	R-HSA-983231	Factors involved in megakaryocyte development and platelet production
pid	ap1_pathway	AP-1 transcription factor network
pid	hdac_classi_pathway	Signaling events mediated by HDAC Class I
pid	hdac_classii_pathway	Signaling events mediated by HDAC Class II
pid	hif1_tfpathway	HIF-1-alpha transcription factor network
wikipathways	WP236	Adipogenesis
wikipathways	WP2849	Hematopoietic Stem Cell Differentiation
wikipathways	WP3527	Preimplantation Embryo
wikipathways	WP3946	White fat cell differentiation
wikipathways	WP4149	White fat cell differentiation
wikipathways	WP4211	Transcriptional cascade regulating adipogenesis
wikipathways	WP706	Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD82	Quiflapon	2
iGMDRD213	SMR000068650	2
iGMDRD267	Oligomycin A	3
iGMDRD68	Paclitaxel	1
iGMDRD158	NSC141540	1
iGMDRD137	Indisulam	3
iGMDRD123	Isoevodiamine	3
iGMDRD698	Neratinib	6
iGMDRD512	nutlin 3	6
iGMDRD451	Serdemetan	3
iGMDRD64	Parbendazole	3
iGMDRD562	Navitoclax	3
iGMDRD888	Compound 44	1
iGMDRD74	Idarubicin	4
iGMDRD399	Selumetinib	3
iGMDRD887	Compound 23 citrate	3
iGMDRD100	Zebularine	2
iGMDRD188	Piperlongumine	4
iGMDRD52	Rotenone	2
iGMDRD187	BRD9876	3
iGMDRD294	Batimastat	3
iGMDRD782	DC-45-A2	2
iGMDRD171	Pemetrexed	3
iGMDRD255	SB225002	2
iGMDRD260	FQI-2	3
iGMDRD679	Bistramide A	3
iGMDRD466	Chaetocin	3
iGMDRD280	CYTOCHALASIN B	2
iGMDRD61	Kinetin riboside	6
iGMDRD152	179324-69-7	1
iGMDRD316	N9-Isopropyl-olomoucine	2
iGMDRD201	SKI II	2
iGMDRD446	LY 2183240	2
iGMDRD24	Fasudil	1
iGMDRD494	Neopeltolide	3
iGMDRD144	NSC95397	2
iGMDRD1008	SR-II-138A	3
iGMDRD772	BRD4770	2
iGMDRD579	PF750	2
iGMDRD420	Leucascandrolide A	3
iGMDRD151	CHM-1	3
iGMDRD126	Tipifarnib	5

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GATA2

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.