iGMDRD24


Canonical SMILES: C1CNCCN(C1)S(=O)(=O)C2=CC=CC3=C2C=CN=C3

InChI: InChI=1S/C14H17N3O2S/c18-20(19,17-9-2-6-15-8-10-17)14-4-1-3-12-11-16-7-5-13(12)14/h1,3-5,7,11,15H,2,6,8-10H2

InChI Key: NGOGFTYYXHNFQH-UHFFFAOYSA-N

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Standard Name
CHEMBL
Pubchem CID
DRUGBANK ID
Drug Status
Drug Type
Standard NameFasudil
Pubchem CID3547
DRUGBANK IDDB08162
Drug StatusAlone
Drug TypeSmall Molecule


Drug-model tissue-cancer distribution: Bubble Plot

LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: Lung Adenocarcinoma (LUAD) model num: 1

Drug-gene pathway enrichments

2wikipathways: White fat cell differentiation1wikipathways: Adipogenesis1pid: HIF-1-alpha transcription factor network1wikipathways: Hematopoietic Stem Cell Differentiation1wikipathways: Preimplantation Embryo1wikipathways: Transcriptional cascade regulating adipogenesis1pid: Signaling events mediated by HDAC Class II1wikipathways: Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways1pid: Signaling events mediated by HDAC Class I1reactome: Gene expression (Transcription)

Drug-gene GO enrichments

3BP: positive regulation of transcription by RNA polymerase II3MF: RNA polymerase II transcription factor activity, sequence-specific DNA binding2CC: nucleus2BP: positive regulation of angiogenesis2BP: positive regulation of gene expression2MF: DNA-binding transcription factor activity2MF: RNA polymerase II proximal promoter sequence-specific DNA binding2CC: nucleoplasm2MF: transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding1BP: cell maturation

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
2624 GATA2 1
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Gene in drug-gene network: Network Plot

Models in Fasudil

Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
EXP(GATA2) gene 22541434 LUNG Lung Adenocarcinoma (LUAD) Fasudil sensitivity in vivo
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